5fd6b7109a4391128ec09f6fc8d628c9 270272.pdf 93b4ee4a1366f536aee58922df1460c3201ea01e 270272.pdf ca7b3892191222ff8af75e84fe0298f0ec2b2f2ea5756efed98650c6f3803127 270272.pdf Title: TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels Subject: Alzheimer's & Dementia 2021.17:1628-1640 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Fri Oct 29 16:41:43 2021 CEST ModDate: Fri Feb 3 11:27:33 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2660412 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BCOAAD+Lato-Regular Type 1C WinAnsi yes yes no 50 0 BCOAGB+Lato-Bold Type 1C WinAnsi yes yes no 51 0 BCOAMP+Lato-Italic Type 1C WinAnsi yes yes no 52 0 Times-Roman Type 1 WinAnsi no no no 2 0 BCOBNN+STIXTwoText Type 1C Custom yes yes yes 62 0 BCOBKL+STIXTwoMath Type 1C Custom yes yes yes 63 0 BCOBLL+STIXTwoText-Italic Type 1C Custom yes yes yes 64 0 BCOBNM+Lato-Black Type 1C WinAnsi yes yes no 65 0 BCOCFK+STIX-Regular Type 1C Custom yes yes yes 90 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-04 02:37:02 CET RepresentationInformation: 270272.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-03 11:55:11 CET Size: 2660412 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0001' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz12330-supitem-0002' cannot be found Offset: 2580905 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer’s disease biomarker levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 1 | BACKGROUND Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2 | METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: 2.1 | Sample description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.2 | DNA extraction, genotype imputation, and quality control Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.3 | CSF biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.4 | GWAS and post-GWAS analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.5 | Polygenic risk score analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.6 | Replication analyses in ADNI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 3 | RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: 3.1 | GWAS analyses using CSF neurofilament light levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 3.2 | GWAS analyses using CSF YKL-40 levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3.3 | GWAS analyses using CSF neurogranin levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 3.4 | Genetic correlation analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 4 | DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: CONFLICTS OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: AUTHOR CONTRIBUTIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: SUPPORTING INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2100 ImageHeight: 1891 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2100 ImageHeight: 1929 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2100 ImageHeight: 1948 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: BCOBLL+STIXTwoText-Italic FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: BCOBLL+STIXTwoText-Italic Flags: Symbolic, Italic FontBBox: -893, -367, 1298, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BCOBNM+Lato-Black FontSubset: true FirstChar: 49 LastChar: 88 FontDescriptor: FontName: BCOBNM+Lato-Black Flags: Nonsymbolic, ForceBold FontBBox: -83, -179, 1167, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BCOAAD+Lato-Regular FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: BCOAAD+Lato-Regular Flags: Nonsymbolic FontBBox: -94, -183, 1117, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BCOAGB+Lato-Bold FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: BCOAGB+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -89, -181, 1143, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BCOAMP+Lato-Italic FontSubset: true FirstChar: 38 LastChar: 146 FontDescriptor: FontName: BCOAMP+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -115, -250, 1024, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BCOCFK+STIX-Regular FontSubset: true FirstChar: 2 LastChar: 95 FontDescriptor: FontName: BCOCFK+STIX-Regular Flags: Symbolic FontBBox: 0, -125, 637, 609 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BCOBNN+STIXTwoText FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: BCOBNN+STIXTwoText Flags: Symbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BCOBKL+STIXTwoMath FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: BCOBKL+STIXTwoMath Flags: Symbolic FontBBox: 48, -89, 658, 547 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2021-10-29T20:11:43+05:30 2023-02-03T02:27:33-08:00 2023-02-03T02:27:33-08:00 LaTeX with hyperref package Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT 10.1002/alz.12330 10.1002/(ISSN)1552-5279 3 VoR 10.1002/alz.12330 application/pdf TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels uuid:f9f285dc-8d7e-3d33-ad87-707f91712ade uuid:d924e2c2-6a22-40d6-894a-ab154692e10f Pages: Page: Label: 1628 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 124, 601, 131, 609 Destination: 354 Annotation: Subtype: Link Rect: 243, 601, 249, 609 Destination: 354 Annotation: Subtype: Link Rect: 336, 601, 343, 609 Destination: 354 Annotation: Subtype: Link Rect: 429, 601, 436, 609 Destination: 354 Annotation: Subtype: Link Rect: 436, 601, 443, 609 Destination: 354 Annotation: Subtype: Link Rect: 142, 583, 149, 591 Destination: 354 Annotation: Subtype: Link Rect: 149, 583, 156, 591 Destination: 354 Annotation: Subtype: Link Rect: 284, 583, 291, 591 Destination: 354 Annotation: Subtype: Link Rect: 391, 583, 398, 591 Destination: 354 Annotation: Subtype: Link Rect: 503, 583, 509, 591 Destination: 354 Annotation: Subtype: Link Rect: 510, 583, 516, 591 Destination: 354 Annotation: Subtype: Link Rect: 111, 565, 118, 573 Destination: 354 Annotation: Subtype: Link Rect: 118, 565, 125, 573 Destination: 354 Annotation: Subtype: Link Rect: 246, 565, 253, 573 Destination: 354 Annotation: Subtype: Link Rect: 253, 565, 260, 573 Destination: 354 Annotation: Subtype: Link Rect: 342, 565, 348, 573 Destination: 354 Annotation: Subtype: Link Rect: 456, 565, 462, 573 Destination: 354 Annotation: Subtype: Link Rect: 162, 548, 169, 555 Destination: 354 Annotation: Subtype: Link Rect: 319, 547, 330, 555 Destination: 354 Annotation: Subtype: Link Rect: 330, 548, 341, 555 Destination: 354 Annotation: Subtype: Link Rect: 451, 548, 462, 555 Destination: 354 Annotation: Subtype: Link Rect: 463, 547, 474, 555 Destination: 354 Annotation: Subtype: Link Rect: 104, 530, 116, 537 Destination: 354 Annotation: Subtype: Link Rect: 229, 530, 240, 537 Destination: 354 Annotation: Subtype: Link Rect: 332, 530, 343, 537 Destination: 354 Annotation: Subtype: Link Rect: 210, 512, 215, 520 Destination: 43 Annotation: Subtype: Link Rect: 304, 512, 316, 520 Destination: 354 Annotation: Subtype: Link Rect: 416, 512, 427, 520 Destination: 354 Annotation: Subtype: Link Rect: 510, 512, 522, 520 Destination: 354 Annotation: Subtype: Link Rect: 522, 512, 533, 520 Destination: 43 Annotation: Subtype: Link Rect: 140, 494, 151, 502 Destination: 354 Annotation: Subtype: Link Rect: 294, 494, 306, 502 Destination: 43 Annotation: Subtype: Link Rect: 439, 494, 450, 502 Destination: 43 Annotation: Subtype: Link Rect: 109, 476, 121, 484 Destination: 43 Annotation: Subtype: Link Rect: 251, 476, 263, 484 Destination: 43 Annotation: Subtype: Link Rect: 263, 476, 274, 484 Destination: 43 Annotation: Subtype: Link Rect: 274, 476, 286, 484 Destination: 43 Annotation: Subtype: Link Rect: 286, 476, 297, 484 Destination: 43 Annotation: Subtype: Link Rect: 298, 476, 309, 484 Destination: 43 Annotation: Subtype: Link Rect: 457, 476, 469, 484 Destination: 43 Annotation: Subtype: Link Rect: 127, 458, 139, 466 Destination: 43 Annotation: Subtype: Link Rect: 139, 458, 150, 466 Destination: 43 Annotation: Subtype: Link Rect: 319, 458, 330, 466 Destination: 43 Annotation: Subtype: Link Rect: 330, 458, 341, 466 Destination: 43 Annotation: Subtype: Link Rect: 451, 458, 458, 466 Destination: 354 Annotation: Subtype: Link Rect: 70, 440, 81, 448 Destination: 43 Annotation: Subtype: Link Rect: 81, 440, 92, 448 Destination: 43 Annotation: Subtype: Link Rect: 195, 440, 206, 448 Destination: 43 Annotation: Subtype: Link Rect: 301, 440, 313, 448 Destination: 43 Annotation: Subtype: Link Rect: 419, 440, 425, 448 Destination: 354 Annotation: Subtype: Link Rect: 426, 440, 437, 448 Destination: 43 Annotation: Subtype: Link Rect: 135, 422, 146, 430 Destination: 43 Annotation: Subtype: Link Rect: 260, 422, 271, 430 Destination: 43 Annotation: Subtype: Link Rect: 388, 422, 400, 430 Destination: 43 Annotation: Subtype: Link Rect: 400, 422, 411, 430 Destination: 43 Annotation: Subtype: Link Rect: 142, 404, 148, 412 Destination: 354 Annotation: Subtype: Link Rect: 149, 404, 155, 412 Destination: 354 Annotation: Subtype: Link Rect: 155, 404, 167, 412 Destination: 43 Annotation: Subtype: Link Rect: 167, 404, 178, 412 Destination: 43 Annotation: Subtype: Link Rect: 297, 404, 303, 412 Destination: 354 Annotation: Subtype: Link Rect: 304, 404, 310, 412 Destination: 354 Annotation: Subtype: Link Rect: 310, 404, 322, 412 Destination: 43 Annotation: Subtype: Link Rect: 416, 404, 423, 412 Destination: 354 Annotation: Subtype: Link Rect: 423, 404, 435, 412 Destination: 43 Annotation: Subtype: Link Rect: 210, 72, 392, 79 Annotation: Subtype: Link Rect: 78, 29, 183, 37 Thumb: true Page: Label: 1629 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 66, 346, 156, 354 Annotation: Subtype: Link Rect: 133, 215, 182, 222 Annotation: Subtype: Link Rect: 44, 205, 182, 212 Annotation: Subtype: Link Rect: 44, 195, 149, 202 Thumb: true Page: Label: 1630 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 243, 650, 254, 657 Destination: 263 Annotation: Subtype: Link Rect: 105, 625, 110, 631 Destination: 263 Annotation: Subtype: Link Rect: 168, 521, 173, 528 Destination: 263 Annotation: Subtype: Link Rect: 242, 418, 247, 424 Destination: 263 Annotation: Subtype: Link Rect: 169, 405, 175, 411 Destination: 263 Annotation: Subtype: Link Rect: 252, 405, 258, 411 Destination: 263 Annotation: Subtype: Link Rect: 214, 378, 225, 385 Destination: 263 Annotation: Subtype: Link Rect: 179, 340, 184, 346 Destination: 267 Annotation: Subtype: Link Rect: 232, 327, 241, 333 Destination: 267 Annotation: Subtype: Link Rect: 261, 314, 266, 321 Destination: 263 Annotation: Subtype: Link Rect: 244, 275, 262, 282 Destination: 267 Annotation: Subtype: Link Rect: 74, 236, 93, 243 Destination: 267 Annotation: Subtype: Link Rect: 92, 211, 101, 217 Destination: 267 Annotation: Subtype: Link Rect: 279, 172, 288, 178 Destination: 267 Annotation: Subtype: Link Rect: 245, 146, 254, 152 Destination: 267 Annotation: Subtype: Link Rect: 279, 56, 288, 62 Destination: 267 Annotation: Subtype: Link Rect: 305, 65, 387, 72 Thumb: true Page: Label: 1631 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 144, 370, 151, 378 Destination: 87 Annotation: Subtype: Link Rect: 257, 284, 289, 294 Destination: null Annotation: Subtype: Link Rect: 44, 271, 57, 281 Destination: null Annotation: Subtype: Link Rect: 157, 276, 166, 282 Destination: 267 Annotation: Subtype: Link Rect: 272, 194, 289, 203 Destination: null Annotation: Subtype: Link Rect: 44, 181, 72, 190 Destination: null Annotation: Subtype: Link Rect: 165, 185, 174, 191 Destination: 267 Annotation: Subtype: Link Rect: 283, 127, 288, 134 Destination: 263 Annotation: Subtype: Link Rect: 275, 49, 284, 56 Destination: 267 Annotation: Subtype: Link Rect: 541, 438, 550, 444 Destination: 267 Annotation: Subtype: Link Rect: 460, 412, 469, 418 Destination: 267 Annotation: Subtype: Link Rect: 485, 383, 496, 391 Destination: null Annotation: Subtype: Link Rect: 510, 382, 550, 391 Destination: null Annotation: Subtype: Link Rect: 428, 308, 445, 315 Destination: 267 Annotation: Subtype: Link Rect: 377, 205, 385, 211 Destination: 267 Annotation: Subtype: Link Rect: 464, 201, 540, 209 Annotation: Subtype: Link Rect: 541, 205, 550, 211 Destination: 267 Annotation: Subtype: Link Rect: 541, 192, 550, 198 Destination: 267 Annotation: Subtype: Link Rect: 403, 152, 413, 159 Destination: 263 Annotation: Subtype: Link Rect: 467, 98, 474, 106 Destination: 87 Annotation: Subtype: Link Rect: 371, 46, 517, 53 Thumb: true Page: Label: 1632 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 67, 691, 77, 698 Destination: 263 Annotation: Subtype: Link Rect: 169, 666, 178, 672 Destination: 267 Annotation: Subtype: Link Rect: 248, 519, 254, 527 Destination: 87 Annotation: Subtype: Link Rect: 117, 506, 202, 513 Annotation: Subtype: Link Rect: 132, 324, 172, 333 Destination: null Annotation: Subtype: Link Rect: 67, 208, 73, 215 Destination: 157 Annotation: Subtype: Link Rect: 99, 207, 115, 215 Destination: null Annotation: Subtype: Link Rect: 152, 207, 162, 215 Destination: null Annotation: Subtype: Link Rect: 164, 156, 175, 163 Destination: null Annotation: Subtype: Link Rect: 214, 156, 230, 163 Destination: null Annotation: Subtype: Link Rect: 236, 91, 247, 99 Destination: null Annotation: Subtype: Link Rect: 452, 687, 459, 695 Destination: 157 Annotation: Subtype: Link Rect: 484, 687, 500, 695 Destination: null Annotation: Subtype: Link Rect: 535, 687, 546, 695 Destination: null Annotation: Subtype: Link Rect: 419, 663, 436, 670 Destination: 267 Annotation: Subtype: Link Rect: 382, 609, 389, 617 Destination: 157 Annotation: Subtype: Link Rect: 428, 609, 439, 617 Destination: null Annotation: Subtype: Link Rect: 379, 570, 386, 578 Destination: 157 Annotation: Subtype: Link Rect: 411, 570, 427, 578 Destination: null Annotation: Subtype: Link Rect: 448, 570, 459, 578 Destination: null Annotation: Subtype: Link Rect: 448, 532, 460, 539 Destination: 162 Annotation: Subtype: Link Rect: 485, 532, 492, 539 Destination: 157 Annotation: Subtype: Link Rect: 398, 493, 410, 500 Destination: 162 Annotation: Subtype: Link Rect: 435, 493, 446, 500 Destination: null Annotation: Subtype: Link Rect: 460, 467, 466, 474 Destination: 157 Annotation: Subtype: Link Rect: 492, 467, 508, 474 Destination: null Annotation: Subtype: Link Rect: 494, 441, 506, 449 Destination: 162 Annotation: Subtype: Link Rect: 527, 441, 533, 449 Destination: 157 Annotation: Subtype: Link Rect: 319, 428, 357, 436 Destination: null Annotation: Subtype: Link Rect: 378, 428, 389, 436 Destination: null Annotation: Subtype: Link Rect: 305, 389, 357, 397 Destination: null Annotation: Subtype: Link Rect: 375, 298, 386, 306 Destination: null Annotation: Subtype: Link Rect: 488, 285, 499, 293 Destination: null Annotation: Subtype: Link Rect: 453, 259, 464, 267 Destination: null Annotation: Subtype: Link Rect: 525, 262, 534, 269 Destination: 267 Annotation: Subtype: Link Rect: 388, 169, 395, 177 Destination: 157 Annotation: Subtype: Link Rect: 421, 169, 437, 177 Destination: null Annotation: Subtype: Link Rect: 459, 169, 470, 177 Destination: null Annotation: Subtype: Link Rect: 379, 91, 394, 99 Destination: null Annotation: Subtype: Link Rect: 381, 39, 387, 47 Destination: 157 Annotation: Subtype: Link Rect: 422, 39, 438, 47 Destination: null Annotation: Subtype: Link Rect: 468, 39, 479, 47 Destination: null Thumb: true Page: Label: 1633 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 396, 247, 404, 285 Destination: null Annotation: Subtype: Link Rect: 427, 241, 436, 279 Destination: null Thumb: true Page: Label: 1634 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 257, 239, 266, 245 Destination: 267 Annotation: Subtype: Link Rect: 84, 212, 124, 222 Destination: null Annotation: Subtype: Link Rect: 116, 130, 128, 138 Destination: 183 Annotation: Subtype: Link Rect: 152, 130, 159, 138 Destination: 157 Annotation: Subtype: Link Rect: 186, 130, 227, 138 Destination: null Annotation: Subtype: Link Rect: 250, 130, 261, 138 Destination: null Annotation: Subtype: Link Rect: 176, 117, 192, 125 Destination: null Annotation: Subtype: Link Rect: 379, 156, 390, 164 Destination: null Annotation: Subtype: Link Rect: 308, 129, 393, 137 Annotation: Subtype: Link Rect: 395, 133, 404, 139 Destination: 267 Annotation: Subtype: Link Rect: 382, 104, 399, 112 Destination: null Annotation: Subtype: Link Rect: 421, 104, 432, 112 Destination: null Annotation: Subtype: Link Rect: 435, 65, 451, 73 Destination: null Annotation: Subtype: Link Rect: 474, 65, 485, 73 Destination: null Thumb: true Page: Label: 1635 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 257, 230, 266, 236 Destination: 267 Annotation: Subtype: Link Rect: 65, 169, 75, 177 Destination: null Annotation: Subtype: Link Rect: 257, 156, 263, 164 Destination: 157 Annotation: Subtype: Link Rect: 44, 143, 60, 151 Destination: null Annotation: Subtype: Link Rect: 81, 143, 92, 151 Destination: null Annotation: Subtype: Link Rect: 247, 117, 259, 125 Destination: 183 Annotation: Subtype: Link Rect: 280, 117, 287, 125 Destination: 157 Annotation: Subtype: Link Rect: 65, 104, 106, 112 Destination: null Annotation: Subtype: Link Rect: 130, 104, 141, 112 Destination: null Annotation: Subtype: Link Rect: 46, 65, 210, 72 Annotation: Subtype: Link Rect: 498, 129, 504, 137 Destination: 157 Annotation: Subtype: Link Rect: 532, 129, 548, 137 Destination: null Annotation: Subtype: Link Rect: 342, 116, 353, 124 Destination: null Annotation: Subtype: Link Rect: 506, 103, 517, 111 Destination: null Annotation: Subtype: Link Rect: 440, 66, 457, 73 Destination: 267 Thumb: true Page: Label: 1636 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 191, 226, 200, 232 Destination: 267 Annotation: Subtype: Link Rect: 84, 168, 242, 175 Annotation: Subtype: Link Rect: 183, 130, 189, 138 Destination: 157 Annotation: Subtype: Link Rect: 216, 130, 228, 138 Destination: 203 Annotation: Subtype: Link Rect: 250, 130, 261, 138 Destination: null Annotation: Subtype: Link Rect: 44, 78, 60, 86 Destination: null Annotation: Subtype: Link Rect: 219, 78, 231, 86 Destination: 203 Annotation: Subtype: Link Rect: 257, 78, 289, 86 Destination: null Annotation: Subtype: Link Rect: 44, 65, 52, 73 Destination: null Annotation: Subtype: Link Rect: 76, 65, 87, 73 Destination: null Thumb: true Page: Label: 1637 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 128, 729, 137, 735 Destination: 267 Annotation: Subtype: Link Rect: 90, 664, 95, 670 Destination: 263 Annotation: Subtype: Link Rect: 205, 664, 211, 670 Destination: 263 Annotation: Subtype: Link Rect: 252, 661, 263, 669 Destination: null Annotation: Subtype: Link Rect: 223, 612, 232, 618 Destination: 267 Annotation: Subtype: Link Rect: 265, 392, 274, 398 Destination: 267 Annotation: Subtype: Link Rect: 69, 366, 78, 372 Destination: 267 Annotation: Subtype: Link Rect: 145, 275, 150, 282 Destination: 263 Annotation: Subtype: Link Rect: 196, 198, 205, 204 Destination: 267 Annotation: Subtype: Link Rect: 267, 185, 276, 191 Destination: 267 Annotation: Subtype: Link Rect: 251, 159, 256, 165 Destination: 267 Annotation: Subtype: Link Rect: 89, 91, 258, 98 Annotation: Subtype: Link Rect: 62, 81, 71, 87 Destination: 267 Annotation: Subtype: Link Rect: 87, 55, 96, 61 Destination: 267 Annotation: Subtype: Link Rect: 428, 712, 550, 719 Annotation: Subtype: Link Rect: 305, 699, 366, 706 Annotation: Subtype: Link Rect: 520, 674, 531, 682 Destination: null Annotation: Subtype: Link Rect: 539, 674, 546, 682 Destination: null Annotation: Subtype: Link Rect: 425, 560, 430, 567 Destination: 267 Annotation: Subtype: Link Rect: 358, 547, 366, 554 Destination: 267 Annotation: Subtype: Link Rect: 451, 431, 457, 437 Destination: 263 Annotation: Subtype: Link Rect: 516, 431, 522, 437 Destination: 263 Annotation: Subtype: Link Rect: 490, 262, 499, 269 Destination: 267 Annotation: Subtype: Link Rect: 338, 120, 347, 126 Destination: 267 Thumb: true Page: Label: 1638 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 164, 687, 170, 695 Destination: 87 Annotation: Subtype: Link Rect: 204, 583, 289, 590 Annotation: Subtype: Link Rect: 44, 570, 74, 577 Annotation: Subtype: Link Rect: 136, 495, 145, 502 Destination: 267 Annotation: Subtype: Link Rect: 224, 483, 233, 489 Destination: 267 Annotation: Subtype: Link Rect: 246, 352, 273, 359 Destination: 267 Annotation: Subtype: Link Rect: 110, 337, 262, 344 Annotation: Subtype: Link Rect: 177, 314, 186, 321 Destination: 267 Annotation: Subtype: Link Rect: 268, 198, 274, 204 Destination: 263 Annotation: Subtype: Link Rect: 88, 185, 93, 191 Destination: 263 Annotation: Subtype: Link Rect: 123, 159, 129, 165 Destination: 263 Annotation: Subtype: Link Rect: 278, 78, 285, 86 Destination: 87 Annotation: Subtype: Link Rect: 342, 547, 351, 554 Destination: 267 Annotation: Subtype: Link Rect: 517, 405, 526, 411 Destination: 267 Thumb: true Page: Label: 1639 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 187, 129, 236, 137 Thumb: true Page: Label: 1640 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 318, 68, 440, 75 Thumb: true Checksum: b31ba102 Type: CRC32 Checksum: 5fd6b7109a4391128ec09f6fc8d628c9 Type: MD5 Checksum: 93b4ee4a1366f536aee58922df1460c3201ea01e Type: SHA-1