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Title:          Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR
Subject:        Biomedicine & Pharmacotherapy, 141 (2021) 111871. doi:10.1016/j.biopha.2021.111871
Keywords:       Tamoxifen,Raloxifene,Toremifene,SREBP,LXR,Cholesterol
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      Title: Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Materials
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          Title: 2.2 Low density lipoprotein (LDL) and lipoprotein deficient serum (LPDS) preparation
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          Title: 2.3 Preparation of cholesterol-methyl‐β‐cyclodextrin complexes (CholMCD)
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            Title: 2.5.1 DNA Labeling and microarray hybridisation
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            Title: 2.5.2 Microarray analysis
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          Title: 2.6 Real-time PCR assay
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          Title: 2.7 LXRα luciferase reporter assay
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          Title: 2.8 Western blot analysis
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        Title: 3 Results
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          Title: 3.1 Tamoxifen, raloxifene, and toremifene increase the expression of SREBP target genes
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          Title: 3.2 SERMs modulation of SREBP and LXR target gene expression depends on LDL-cholesterol uptake
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          Title: 3.3 LDL-cholesterol but not MCD-cholesterol accumulates within the cells
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          Title: 3.4 SERMs induce SREBP-2 processing and prevent LXR activation
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          Title: 3.5 Estrogen receptor-independent effects of SERMs
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        Title: 4 Discussion
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        Title: 5 Conclusions
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        Title: Funding sources
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        Title: Conflict of interest statement
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        Title: Acknowledgements
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        Title: Appendix A Supporting information
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  Checksum: 7a653c8a
   Type: CRC32
  Checksum: bf88144d503f8f1a697c964052426c14
   Type: MD5
  Checksum: 432fea2f227d8b45265e350de56d3f0bd8d2afc6
   Type: SHA-1