56ab1a143f8ae6ec75a52ea42923b3e0 270291.pdf 49cdfc763c2663eb70adbccce4af1b18158e6931 270291.pdf 293136bf4c5706bb1698f89c53d7c202e88845d6234897e6fa745122ae1c866e 270291.pdf Title: Efficacy and tolerability of the hexanic extract of Serenoa repens compared to tamsulosin in moderate-severe LUTS-BPH patients Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-98586-5 Author: Antonio Alcaraz Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Sep 23 19:26:14 2021 CEST ModDate: Thu Sep 23 21:11:31 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1194305 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UJLPDN+Wingdings-Regular Type 1C WinAnsi yes yes yes 402 0 MinionPro-Regular Type 1C Custom yes no yes 55 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 403 0 HMQGZJ+Corbel-Bold CID TrueType Identity-H yes yes yes 57 0 Corbel2 TrueType WinAnsi yes no yes 58 0 CMCCHT+Corbel CID TrueType Identity-H yes yes yes 59 0 Corbel3 CID TrueType Identity-H yes no yes 439 0 MinionPro-It Type 1C Custom yes no yes 56 0 UXCMUJ+PalatinoLinotype-Roman Type 1C WinAnsi yes yes no 94 0 RNVGMF+MinionPro-BoldIt Type 1C WinAnsi yes yes yes 95 0 MinionPro-Bold Type 1C Custom yes no yes 96 0 THMPGL+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 217 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:09:51 CEST RepresentationInformation: 270291.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:04:56 CEST Size: 1194305 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 485 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Efficacy and tolerability of the hexanic extract of Serenoa repens compared to tamsulosin in moderate-severe LUTS-BPH patients Children: Item: Title: Methods Children: Item: Title: Patients and study design. Item: Title: Study variables. Item: Title: Statistical analysis. Children: Item: Title: Optimising comparability: iterative and propensity score matching. Item: Title: Assessing change over time. Item: Title: Responder analysis. Item: Title: Adverse effects. Item: Title: Sub-group analysis. Item: Title: Results Children: Item: Title: Results based on iterative matching: available data and study flow chart. Item: Title: Sociodemographic and clinical characteristics of the sample after iterative matching. Item: Title: Change in symptoms, QoL and clinical parameters after 6 months (iterative matching sample). Item: Title: Change in IPSS score based on baseline symptom severity (iterative matching sample). Item: Title: Treatment compliance. Item: Title: Adverse effects. Item: Title: Results based on propensity matched samples. Item: Title: Discussion Item: Title: References Item: Title: Acknowledgements Info: Title: Efficacy and tolerability of the hexanic extract of Serenoa repens compared to tamsulosin in moderate-severe LUTS-BPH patients Author: Antonio Alcaraz Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-98586-5 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Sep 23 19:56:14 CEST 2021 ModDate: Thu Sep 23 21:11:31 CEST 2021 ID: 0x7579a84e284bdfe7c240f8211dddfadd, 0xac6b0ed31a3699769418032a64e123d5 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1418 ImageHeight: 720 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1418 ImageHeight: 730 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: HMQGZJ+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: CMCCHT+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UJLPDN+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: UJLPDN+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UXCMUJ+PalatinoLinotype-Roman FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: UXCMUJ+PalatinoLinotype-Roman Flags: Serif, Nonsymbolic FontBBox: -170, -292, 1419, 1050 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: RNVGMF+MinionPro-BoldIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: RNVGMF+MinionPro-BoldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -230, -360, 1684, 1032 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: THMPGL+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: THMPGL+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: HMQGZJ+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HMQGZJ+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: VYHFSH+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VYHFSH+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true XMP: 2021-09-23T22:56:14+05:30 Springer 2021-09-23T21:11:31+02:00 2021-09-23T21:11:31+02:00 application/pdf https://doi.org/10.1038/s41598-021-98586-5 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-98586-5 Efficacy and tolerability of the hexanic extract of Serenoa repens compared to tamsulosin in moderate-severe LUTS-BPH patients Antonio Alcaraz Alfredo Rodríguez-Antolín Joaquín Carballido-Rodríguez David Castro-Díaz José Medina-Polo Jesús M. Fernández-Gómez Vincenzo Ficarra Joan Palou Javier Ponce de León Roca Javier C. Angulo Manuel Esteban-Fuertes José M. Cózar-Olmo Noemí Pérez-León José M. Molero-García Antonio Fernández-Pro Ledesma Francisco J. 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