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Keywords: COVID-19, SARS-CoV-2, host genetics, TLR7, immunodeficiency, genetic screening Author: Xavier Solanich Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Jul 20 11:39:53 2021 CEST ModDate: Tue Jul 20 14:51:57 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 880604 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PMKICJ+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 800 0 PMKIEJ+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 813 0 PMKIAO+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 786 0 PMKIAP+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 787 0 PMKIBA+AdvOT01861455.I Type 1C WinAnsi yes yes no 788 0 PMKIBB+AdvOT01861455.I+20 Type 1C WinAnsi yes yes no 789 0 PMKIBC+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 790 0 PMKICD+AdvPSA18C Type 1C WinAnsi yes yes no 791 0 PMKICE+AdvOT1deab444.I Type 1C WinAnsi yes yes no 792 0 PMKICF+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 793 0 PMKICG+AdvPSA323 Type 1C WinAnsi yes yes no 794 0 PMKICH+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 801 0 PMKICI+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 802 0 PMKIJI+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 197 0 PMKIJJ+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 188 0 PMKIJK+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 193 0 PMKIJL+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 183 0 PMKIJM+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 181 0 PMKIKM+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 185 0 PMKIKN+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 202 0 PMKILO+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 206 0 PMKILP+AdvOT34fe1490.B+20 Type 1C WinAnsi yes yes no 203 0 PMKJGM+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 209 0 PMKJJL+AdvOT6e5d2ec0+22 Type 1C Custom yes yes yes 210 0 PMKJKM+AdvOT2f02755f.I Type 1C WinAnsi yes yes no 211 0 PMKKIH+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 212 0 PMKKJI+AdvTT58d178b9+03 Type 1C Custom yes yes yes 215 0 PMKKLI+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 219 0 PMKKLJ+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 218 0 PMKKLK+AdvOT7d6df7ab.I+01 Type 1C MacRoman yes yes no 220 0 PMKKLL+AdvTT02dee1cd.I+03 Type 1C Custom yes yes yes 221 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-01-27 02:30:07 CET RepresentationInformation: 270509.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-26 14:09:27 CET Size: 880604 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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application/pdf Xavier Solanich Gardenia Vargas-Parra Caspar I. van der Made Annet Simons Janneke Schuurs-Hoeijmakers Arnau Antol&iacute Jes&uacute s del Valle Gemma Rocamora-Blanch Fernando Setién Manel Esteller Simon V. van Reijmersdal Antoni Riera-Mestre Joan Sabater-Riera Gabriel Capellá Frank L. van de Veerdonk Ben van der Hoven Xavier Corbella Alexander Hoischen Conxi Lázaro Introduction: Loss-of-function TLR7 variants have been recently reported in a small number of males to underlie strong predisposition to severe COVID-19. 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