c71adc1dfaf4a5fd98a483fb1a896128 fimmu-12-734652.pdf 3c60bfd0a3b1c10947c993fcbb7f7d7b25136199 fimmu-12-734652.pdf c65be2967f0ed34103f023174de4ebc93f7b46d76a7275db5764020d6653f688 fimmu-12-734652.pdf Title: JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis Subject: Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections Keywords: monocytes, endotoxin tolerance, sepsis, DNA methylation, tolerized genes, STATs, JAK2, TET2 Author: Octavio Morante-Palacios Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Sat Nov 13 02:15:00 2021 CET ModDate: Mon Nov 15 01:44:22 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 6673920 bytes 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Objects: 651 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins 椀渀 匀攀瀀猀椀猩㸾൥湤潢樍㘲㜠〠潢樼㰯䙩牳琠㘲㠠〠刯偡牥湴‶ㄷ‰⁒⽎數琠㘲㘠〠刯䑥獴⣾＀猀㌩⽃潵湴‴⽌慳琠㘲㤠〠刯偲敶‶㌰‰⁒⽔楴汥⣾＀刀攀猀甀氀琀猩㸾൥湤潢樍㘳〠〠潢樼㰯䙩牳琠㘳ㄠ〠刯偡牥湴‶ㄷ‰⁒⽎數琠㘲㜠〠刯䑥獴⣾＀猀㈩⽃潵湴‱㔯䱡獴‶㌲‰⁒⽐牥瘠㘱㠠〠刯呩瑬攨Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Human Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: CD14+ Monocytes Purification and Culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Transfection of Primary Human Monocytes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Cytokine Measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: DNA Methylation Profiling and Pyrosequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Quality Control, Data Normalization, and Detection of Differentially Methylated CpGs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: RNA Purification and RNA-Seq Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Gene Ontology Over-Representation Analysis, Gene Set Enrichment Analysis and Transcription Factor Enrichment Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Accessibility and Histone-Mark Profiling of Differentially Methylated CpGs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methylation and Expression Association Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Quantitative Reverse-Transcription Polymerase Chain Reaction (qRT-PCR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Western Blotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: pSTAT1 Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Mann–Whitney U Test and Student’s Paired T Test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: RNA-Seq Public Data Reanalysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: TLR2/4 Stimulation of Monocytes Yields Specific DNA Demethylation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: LPS-Driven Gene Expression Changes Are Correlated With DNA Methylation and Are Concomitant With STAT1, STAT3 and STAT5 Activat椀漀温㸾൥湤潢樍ㄠ〠潢樼㰯䍲潰䉯硛〠〠㔹㔮㈷㘠㜷㤮㔲㡝⽁湮潴獛㈠〠删㌠〠删㐠〠删㔠〠删㘠〠删㜠〠删㠠〠删㤠〠删㄰‰⁒‱ㄠ〠删ㄲ‰⁒‱㌠〠删ㄴ‰⁒‱㔠〠删ㄶ‰⁒‱㜠〠删ㄸ‰⁒‱㤠〠删㈰‰⁒′ㄠ〠删㈲‰⁒′㌠〠删㈴‰⁒′㔠〠删㈶‰⁒崯偡牥湴‴㠷‰⁒⽂嬵ㄶ‰⁒‵㔲‰⁒‵㔱‰⁒崯䍯湴敮瑳′㠠〠刯副瑡瑥‰⽍敤楡䉯硛〠〠㔹㔮㈷㘠㜷㤮㔲㡝⽒敳潵牣敳′㜠〠刯呹灥⽐慧放㸍敮摯扪ല‰扪㰼⽒散瑛㈴〮㈶㔠㘵ㄮ㜴㈠㈴㐮㠵㜠㘶ㄮ㈰㥝⽓畢瑹灥⽌楮欯䉯牤敲嬰‰‰崯䑥獴⣾＀䈀ㄩ⽔祰支䅮湯琾㸍敮摯扪ള‰扪㰼⽒散瑛㈳㔮㐴㘠㘱㜮㈱㘠㈴〮㐳㔠㘲㘮㜴崯卵扴祰支䱩湫⽂潲摥牛〠〠そ⽄敳琨B2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Inhibition of JAK2 Partially Prevents the Activation of LPS-Upregulated Genes and Tolerance-Related Genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Relevance of the JAK2/STAT Pathway in Monocytes From Septic Patients Infected With Gram-Negative Bacteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis Author: Octavio Morante-Palacios Subject: 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widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections monocytes endotoxin tolerance sepsis DNA methylation tolerized genes STATs JAK2 TET2 uuid:3fec590d-4177-4072-878e-cc19a14da250 uuid:35d9dc63-3e5e-443e-a148-13a883532dcd Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 519, 540, 540 Annotation: Subtype: Link Rect: 175, 496, 538, 517 Annotation: Subtype: Link Rect: 175, 473, 536, 494 Annotation: Subtype: Link Rect: 175, 450, 477, 471 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 408, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 498, 158, 506 Annotation: Subtype: Link Rect: 63, 339, 158, 346 Annotation: Subtype: Link Rect: 57, 64, 158, 71 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 458, 728, 549, 735 Annotation: Subtype: Link Rect: 448, 720, 549, 727 Annotation: Subtype: 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