f74142f04a0ead6dc344fb6a59079155 fcell-09-715126-1.pdf ccc21f591fb6b7c398d8713aac7ed1f5f536c4c1 fcell-09-715126-1.pdf e2cf956137b1e338f65a0645659bad158dae8b95aa6ac906ee0042f92d7da7b9 fcell-09-715126-1.pdf Title: Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy Subject: Background: Chromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). Keywords: chaetocin, tazemetostat, ionizing radiation, doxorubicin, DNA repair, histone Methylation, 53BP1 foci, H2AX foci Author: Pedro A. Lazo Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Sat Aug 28 06:42:07 2021 CEST ModDate: Sat Aug 28 07:42:38 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 5881414 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OFLPKB+MTGU Type 1 Builtin yes yes no 43 0 HUMTYE+MinionPro-Regular Type 1 Custom yes yes no 33 0 NTIHGF+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 34 0 LUDXIG+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 35 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 40 0 VREXCM+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 41 0 DBBMUF+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 42 0 YSHZQC+MinionPro-It Type 1 Custom yes yes no 220 0 YNOMEH+MinionPro-Bold Type 1 Custom yes yes no 233 0 TDHOFM+MTSYN Type 1 Builtin yes yes no 334 0 PAARCL+RBLMI Type 1 Builtin yes yes no 468 0 CNPMIT+MTGUB Type 1 Builtin yes yes no 543 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-24 02:39:35 CEST RepresentationInformation: fcell-09-715126-1.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-20 17:49:28 CET Size: 5881414 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 32 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Reagents and Inhibitors Item: Title: Cell Lines and Culture Item: Title: DNA Damage Item: Title: Cell Lysates and Histone Extraction Item: Title: Antibodies Item: Title: SDS-Page Electrophoresis and Western Blot Analysis Item: Title: Immunofluorescence and Confocal Microscopy Item: Title: TUNEL Assays Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Chaetocin Induces DNA Damage by Itself and Impairs the Recruitment of 53BP1 at Damage Sites Item: Title: The Effect of Chaetocin on 53BP1 Foci Formation Is Independent of the Agent Used to Induce DNA Damage Item: Title: MDC1 and NBS1, Intermediate DDR Proteins Between H2AX and 53BP1 Foci Formation, Are Not Affected by Chaetocin Treatment Item: Title: H4K20me2 Induced by DNA Damage Are Impaired by Chaetocin Treatment Item: Title: Tazemetostat Impairs H4K20me2 the DNA Damage Response Induced by Doxorubicin Item: Title: JMJD2 Inhibitor Does Not Alter the Formation of 53BP1 Foci Induced by DNA Damage Item: Title: Chaetocin and Tazemetostat Facilitate DNA Damage Induced by Doxorubicin Item: Title: Chaetocin and Tazemetostat Promote Cell Death in Response to DNA Damage Induction Item: Title: Discussion Item: Title: Conclusion Item: Title: Data Availability Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: HUMTYE+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: HUMTYE+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NTIHGF+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 3 LastChar: 124 FontDescriptor: FontName: NTIHGF+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LUDXIG+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: LUDXIG+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PAARCL+RBLMI 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pdfTeX-1.40.15 1.5 application/pdf fcell-09-715126.tex Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy Background: Chromatin is dynamically remodeled to adapt to all DNA-related processes, including DNA damage responses (DDR). Pedro A. 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