d15e26d024667748b39d4a5d7f28faa0 cancers-13-02465.pdf b945c9add73f09c9071f13bdb15887704cae0b22 cancers-13-02465.pdf 2b76733194973ba66a62d1cb385b97a8d1ab1039df51b05d8f7adfc1ee0ec4b5 cancers-13-02465.pdf Title: Current and Novel Alkylators in Multiple Myeloma Subject: A large number of novel treatments for myeloma have been developed and approved; however, alkylating drugs continue to be part of standard regimens. Additionally, novel alkylators are currently being developed. We performed a non-systematized literary search for relevant papers and communications at large conferences, as well as exploiting the authors’ knowledge of the field, to review the history, current use and novel concepts around the traditional alkylators cyclophosphamide, bendamustine and melphalan and current data on the newly developed pro-drug melflufen. Even in the era of targeted treatment and personalized medicine, alkylating drugs continue to be part of the standard-of-care in myeloma, and new alkylators are coming to the market. Keywords: alkylator; myeloma; melflufen; melphalan; bendamustine; cyclophosphamide Author: Fredrik Schjesvold and Albert Oriol Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri May 21 10:49:51 2021 CEST ModDate: Fri May 21 10:49:51 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 531865 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JLUXJK+URWPalladioL-Ital Type 1 Custom yes yes no 80 0 GKZDSL+URWPalladioL-Bold Type 1 Custom yes yes no 81 0 NFLKKK+URWPalladioL-Roma Type 1 Custom yes yes no 82 0 UQJVBU+VnURWPalladioL Type 1 Custom yes yes no 85 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 91 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 108 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 109 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 110 0 KADLLD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 233 0 KADLME+PalatinoLinotype TrueType WinAnsi yes yes no 234 0 KADLMG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 235 0 HCPSKZ+CMSY10 Type 1 Builtin yes yes no 252 0 ICBUDW+URWPalladioL-BoldItal Type 1 Custom yes yes no 384 0 JCALCI+PalatinoLinotype TrueType WinAnsi yes yes no 476 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 531 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-24 02:39:30 CEST RepresentationInformation: cancers-13-02465.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-24 15:42:23 CET Size: 531865 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 18 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false 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