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Title:          Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Subject:        Scientific Reports, https://doi.org/10.1038/s41598-021-82917-7
Author:         Juan Miguel Baquero 
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     Item: 
      Title: Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
      Children: 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Telomeres are a hotspot for oxidation due to cell cycle ROS production. 
         Item: 
          Title: OGG1 initiates BER at telomeres upon OS. 
         Item: 
          Title: Pharmacological OGG1 inhibition disrupts BER at telomeres upon OS. 
         Item: 
          Title: Pharmacological OGG1 inhibition results in telomere losses and post-mitotic defects. 
         Item: 
          Title: TH5487 synergizes with conventional anticancer drugs through induction of intracellular ROS, telomere DNA damage, and genome instability. 
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Cell culture and treatments. 
         Item: 
          Title: Plasmid construction OGG1-GFP and transfection. 
         Item: 
          Title: CRISPRCas9 knockout of OGG1. 
         Item: 
          Title: IF microscopy and image analysis. 
         Item: 
          Title: Telomere fluorescence in situ hybridization (Telo-FISH). 
         Item: 
          Title: Cell sorting. 
         Item: 
          Title: Colony formation assay. 
         Item: 
          Title: DNA extraction, human OGG1 purification and relative quantification of oxidized bases in specific genome regions by quantitative PCR (qPCR). 
         Item: 
          Title: Protein extraction, quantification, and immunoblotting. 
         Item: 
          Title: Detection of intracellular ROS during cell cycle phases by flow cytometry. 
         Item: 
          Title: Chromatin immunoprecipitation (ChIP). 
         Item: 
          Title: OGG1 target engagement. 
         Item: 
          Title: Synergy experiments. 
         Item: 
          Title: Statistical analysis. 
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
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       Rect: 358, 251, 517, 239
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: efb84b15
   Type: CRC32
  Checksum: f58638f8f0be9cf8f12b9515ec3866d0
   Type: MD5
  Checksum: d7d9404b6e04ee1aed3512fb62b29006ccc801fd
   Type: SHA-1