3099b375cd8aecabfe682e90b4e70d75 cancers-13-00728-v2-1.pdf 10094404ab30fdb0efa26c94b2615790eb6cd485 cancers-13-00728-v2-1.pdf 1182b5905d910f771a08507ec09a2a8ff21ba40b5954eb0c1390710d6a211ea1 cancers-13-00728-v2-1.pdf Title: Circulating Cell-Free DNA in Breast Cancer: Searching for Hidden Information towards Precision Medicine Subject: Breast cancer (BC) is a leading cause of death between women. Mortality is significantly raised due to drug resistance and metastasis, while personalized treatment options are obstructed by the limitations of conventional biopsy follow-up. Lately, research is focusing on circulating biomarkers as minimally invasive choices for diagnosis, prognosis and treatment monitoring. Circulating cell-free DNA (ccfDNA) is a promising liquid biopsy biomaterial of great potential as it is thought to mirror the tumor’s lifespan; however, its clinical exploitation is burdened mainly by gaps in knowledge of its biology and specific characteristics. The current review aims to gather latest findings about the nature of ccfDNA and its multiple molecular and biological characteristics in breast cancer, covering basic and translational research and giving insights about its validity in a clinical setting. Keywords: breast cancer; biomarker; circulating cell-free DNA; liquid biopsy; prognosis; monitoring Author: Maria Panagopoulou, Manel Esteller and Ekaterini Chatzaki Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Feb 20 08:33:21 2021 CET ModDate: Sat Feb 20 09:51:55 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1211117 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- COLRXC+URWPalladioL-Ital Type 1 Custom yes yes no 10 0 ZKCJWZ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 AISZVH+URWPalladioL-Roma Type 1 Custom yes yes no 19 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 50 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 54 0 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Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 805 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Liquid Biopsy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Circulating Cell-Free DNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Methylation of ccfDNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Methylation of ccfDNA as Diagnostic Biomarker in Breast Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Methylation of ccfDNA as Prognostic Biomarker in Breast Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Methylation of ccfDNA as a Biomarker Predicting Treatment Response in Breast Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Hypomethylation in Breast Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Other Parameters of ccfDNA in Breast Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Quantity of ccfDNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Integrity of ccfDNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: ccfDNA Releasing Mechanism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Circulating Structures of ccfDNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Nucleosomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Vitrosomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Extracellular Vesicles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Circulating Cell-Free Mitochondrial DNA (cf mtDNA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: ccfDNA Biology in BC: Evidence from In Vitro Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Multi-Parametric Analysis of ccfDNA Features Using Machine Learning Approaches Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Info: Title: Circulating Cell-Free DNA in Breast Cancer: Searching for Hidden Information towards Precision Medicine Author: Maria Panagopoulou, Manel Esteller and Ekaterini Chatzaki Subject: Breast cancer (BC) is a leading cause of death between women. Mortality is significantly raised due to drug resistance and metastasis, while personalized treatment options are obstructed by the limitations of conventional biopsy follow-up. Lately, research is focusing on circulating biomarkers as minimally invasive choices for diagnosis, prognosis and treatment monitoring. Circulating cell-free DNA (ccfDNA) is a promising liquid biopsy biomaterial of great potential as it is thought to mirror the tumor’s lifespan; however, its clinical exploitation is burdened mainly by gaps in knowledge of its biology and specific characteristics. The current review aims to gather latest findings about the nature of ccfDNA and its multiple molecular and biological characteristics in breast cancer, covering basic and translational research and giving insights about its validity in a clinical setting. 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Type: MD5 Checksum: 10094404ab30fdb0efa26c94b2615790eb6cd485 Type: SHA-1