2513de62466bad891e092b804d1c1709 270596.pdf 8c244e93df6ffe5389b8e02a9334a508fe4f35b0 270596.pdf 38d1131121410247dd40aa8991a56d18e75c94ff3345414ac47f637bb0916aec 270596.pdf Title: Gene Expression Analysis of the Bone Marrow Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease Subject: Background: We previously reported algorithms based on clinical parameters and plasma cell characteristics to identify patients with smoldering multiple myeloma (SMM) with higher risk of progressing who could benefit from early treatment. 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Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease Ignacio Isola Fara Bras&oacute -Maristany David F. Moreno Mari-Pau Mena Aina Oliver-Calders Laia Paré Luis Gerardo Rodr&iacute guez-Lobato Beatriz Martin-Antonio Mar&iacute a Teresa Cibeira Joan Bladé Laura Rosiñol Aleix Prat Ester Lozano Carlos Fernández de Larrea Background: We previously reported algorithms based on clinical parameters and plasma cell characteristics to identify patients with smoldering multiple myeloma (SMM) with higher risk of progressing who could benefit from early treatment. smoldering multiple myeloma immunotherapy immune checkpoints TIGIT pronostic factors bone marrow microenvironment uuid:a1c70d11-d42e-4661-af3d-f8e0e1716306 uuid:fb743fde-b09b-492a-a2e2-14f837a1c824 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 605, 496, 626 Annotation: Subtype: Link Rect: 175, 582, 497, 603 Annotation: Subtype: Link Rect: 175, 559, 501, 580 Annotation: Subtype: Link Rect: 175, 536, 471, 557 Annotation: Subtype: Link Rect: 175, 513, 464, 534 Annotation: Subtype: Link Rect: 175, 490, 392, 511 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