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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 2. Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 2.1. Study design and participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.2. Ethics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.3. DNA methylation data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.4. Computational analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.5. Role of funders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: 3.1. Patients and epigenotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 3.2. Epigenome-wide association analysis in the discovery cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 3.3. Testing EWAS markers in the validation cohort and development of the EPICOVID signature Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Contributors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Data sharing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: Epigenome-wide association study of COVID-19 severity with respiratory failure Author: Manuel Castro de Moura Subject: EBioMedicine, 66 (2021) 103339. doi:10.1016/j.ebiom.2021.103339 Keywords: "Coronavirus"; "SARS-CoV-2"; "COVID-19"; "Epigenetics"; "DNA methylation" Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Apr 22 21:13:30 CEST 2021 ModDate: Thu Apr 22 13:44:00 CEST 2021 ID: 0x4b7ed823bb900ce229911c6673a8525c, 0x1cb56009a2311865f897b4ea3310cbe7 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 224 ImageHeight: 299 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1417 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1170 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: NAJMCK+AdvTTb83ee1dd.B FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: NAJMCK+AdvTTb83ee1dd.B Flags: Nonsymbolic FontBBox: -93, -250, 1041, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJLBN+AdvTT5843c571 FontSubset: true FirstChar: 184 LastChar: 184 FontDescriptor: FontName: NAJLBN+AdvTT5843c571 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJMDN+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 48 FontDescriptor: FontName: NAJMDN+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NAJEEG+AdvOT5fa4e291 FontSubset: true FirstChar: 37 LastChar: 237 FontDescriptor: FontName: NAJEEG+AdvOT5fa4e291 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJMDM+AdvOT5fa4e291+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: NAJMDM+AdvOT5fa4e291+20 Flags: Nonsymbolic FontBBox: 19, -208, 947, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJLAL+AdvOTf2586c63 FontSubset: true FirstChar: 39 LastChar: 237 FontDescriptor: FontName: NAJLAL+AdvOTf2586c63 Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJMFN+AdvP4A5FDB FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: NAJMFN+AdvP4A5FDB Flags: Nonsymbolic FontBBox: 0, -239, 979, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJKPL+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: NAJKPL+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NAJMBJ+AdvP4C9543 FontSubset: true FirstChar: 1 LastChar: 163 FontDescriptor: FontName: NAJMBJ+AdvP4C9543 Flags: Symbolic FontBBox: 0, -947, 1041, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NAJMBI+AdvOT5fa4e291+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: NAJMBI+AdvOT5fa4e291+fb Flags: Symbolic FontBBox: 40, 0, 572, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NAJLIL+AdvPAC3D FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: NAJLIL+AdvPAC3D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJMCL+AdvP4C9542 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: NAJMCL+AdvP4C9542 Flags: Nonsymbolic FontBBox: 0, -208, 979, 677 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NAJLAM+AdvOTf2586c63+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NAJLAM+AdvOTf2586c63+fb Flags: Symbolic FontBBox: -114, -208, 833, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2021-04-23T00:13:30+05:30 Elsevier 2021-04-22T11:44-07:00 2021-04-22T11:44-07:00 Acrobat Distiller 10.0.0 (Windows) "Coronavirus"; "SARS-CoV-2"; "COVID-19"; "Epigenetics"; "DNA methylation" application/pdf doi:10.1016/j.ebiom.2021.103339 Elsevier B.V. EBioMedicine, 66 (2021) 103339. doi:10.1016/j.ebiom.2021.103339 Coronavirus SARS-CoV-2 COVID-19 Epigenetics DNA methylation Epigenome-wide association study of COVID-19 severity with respiratory failure Manuel Castro de Moura Veronica Davalos Laura Planas-Serra Damiana Alvarez-Errico Carles Arribas Montserrat Ruiz Sergio Aguilera-Albesa Jesús Troya Juan Valencia-Ramos Valentina Vélez-Santamaria Agustí Rodríguez-Palmero Judit Villar-Garcia Juan P. Horcajada Sergiu Albu Carlos Casasnovas Anna Rull Laia Reverte Beatriz Dietl David Dalmau Maria J. Arranz Laia Llucià-Carol Anna M. Planas Jordi Pérez-Tur Israel Fernandez-Cadenas Paula Villares Jair Tenorio Roger Colobran Andrea Martin-Nalda Pere Soler-Palacin Francesc Vidal Aurora Pujol Manel Esteller uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:c0de57b6-1630-469a-801f-1087aff7d07e journal © 2021 The Authors. Published by Elsevier B.V. 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Annotation: Subtype: Link Rect: 326, 217, 562, 223 Annotation: Subtype: Link Rect: 326, 209, 562, 215 Annotation: Subtype: Link Rect: 326, 201, 429, 207 Annotation: Subtype: Link Rect: 326, 193, 562, 199 Annotation: Subtype: Link Rect: 326, 185, 562, 191 Annotation: Subtype: Link Rect: 326, 177, 407, 183 Annotation: Subtype: Link Rect: 326, 169, 562, 175 Annotation: Subtype: Link Rect: 326, 161, 500, 167 Annotation: Subtype: Link Rect: 326, 153, 442, 159 Annotation: Subtype: Link Rect: 445, 153, 562, 159 Annotation: Subtype: Link Rect: 326, 145, 489, 152 Annotation: Subtype: Link Rect: 326, 137, 562, 144 Annotation: Subtype: Link Rect: 326, 129, 562, 136 Annotation: Subtype: Link Rect: 326, 121, 401, 128 Annotation: Subtype: Link Rect: 326, 113, 562, 120 Annotation: Subtype: Link Rect: 326, 105, 540, 112 Annotation: Subtype: Link Rect: 452, 81, 552, 88 Annotation: Subtype: Link Rect: 326, 73, 562, 80 Annotation: Subtype: Link Rect: 326, 65, 562, 72 Annotation: Subtype: Link Rect: 326, 57, 562, 64 Annotation: Subtype: Link Rect: 326, 50, 378, 56 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 48, 727, 283, 733 Annotation: Subtype: Link Rect: 48, 719, 283, 725 Annotation: Subtype: Link Rect: 48, 711, 220, 717 Annotation: Subtype: Link Rect: 48, 703, 283, 709 Annotation: Subtype: Link Rect: 48, 695, 251, 701 Annotation: Subtype: Link Rect: 48, 687, 283, 693 Annotation: Subtype: Link Rect: 48, 679, 283, 686 Annotation: Subtype: Link Rect: 48, 671, 78, 678 Annotation: Subtype: Link Rect: 48, 663, 283, 670 Annotation: Subtype: Link Rect: 48, 655, 283, 662 Annotation: Subtype: Link Rect: 48, 647, 126, 654 Annotation: Subtype: Link Rect: 48, 639, 283, 646 Annotation: Subtype: Link Rect: 48, 631, 244, 638 Annotation: Subtype: Link Rect: 48, 623, 283, 630 Annotation: Subtype: Link Rect: 48, 615, 283, 622 Annotation: Subtype: Link Rect: 48, 607, 283, 614 Annotation: Subtype: Link Rect: 48, 599, 201, 606 Annotation: Subtype: Link Rect: 48, 591, 283, 598 Annotation: Subtype: Link Rect: 48, 583, 228, 590 Annotation: Subtype: Link Rect: 232, 583, 283, 590 Annotation: Subtype: Link Rect: 48, 576, 171, 582 Annotation: Subtype: Link Rect: 48, 568, 283, 574 Annotation: Subtype: Link Rect: 48, 560, 283, 566 Annotation: Subtype: Link Rect: 48, 552, 173, 558 Annotation: Subtype: Link Rect: 48, 544, 283, 550 Annotation: Subtype: Link Rect: 48, 536, 283, 542 Annotation: Subtype: Link Rect: 48, 528, 86, 534 Annotation: Subtype: Link Rect: 48, 520, 283, 526 Annotation: Subtype: Link Rect: 48, 512, 283, 518 Annotation: Subtype: Link Rect: 48, 504, 214, 510 Annotation: Subtype: Link Rect: 48, 496, 283, 502 Annotation: Subtype: Link Rect: 48, 488, 283, 494 Annotation: Subtype: Link Rect: 48, 480, 204, 486 Annotation: Subtype: Link Rect: 317, 727, 552, 733 Annotation: Subtype: Link Rect: 317, 719, 552, 725 Annotation: Subtype: Link Rect: 317, 711, 432, 717 Annotation: Subtype: Link Rect: 317, 703, 345, 709 Annotation: Subtype: Link Rect: 348, 703, 552, 709 Annotation: Subtype: Link Rect: 317, 695, 552, 701 Annotation: Subtype: Link Rect: 317, 687, 385, 693 Annotation: Subtype: Link Rect: 317, 679, 430, 686 Annotation: Subtype: Link Rect: 433, 679, 552, 686 Annotation: Subtype: Link Rect: 317, 671, 552, 678 Annotation: Subtype: Link Rect: 317, 663, 400, 670 Annotation: Subtype: Link Rect: 317, 655, 552, 662 Annotation: Subtype: Link Rect: 317, 647, 481, 654 Annotation: Subtype: Link Rect: 317, 639, 552, 646 Annotation: Subtype: Link Rect: 317, 631, 552, 638 Annotation: Subtype: Link Rect: 317, 623, 374, 630 Annotation: Subtype: Link Rect: 317, 615, 552, 622 Annotation: Subtype: Link Rect: 317, 607, 552, 614 Annotation: Subtype: Link Rect: 317, 599, 392, 606 Annotation: Subtype: Link Rect: 317, 591, 552, 598 Annotation: Subtype: Link Rect: 317, 583, 552, 590 Annotation: Subtype: Link Rect: 317, 576, 370, 582 Annotation: Subtype: Link Rect: 317, 568, 552, 574 Annotation: Subtype: Link Rect: 317, 560, 552, 566 Annotation: Subtype: Link Rect: 317, 552, 442, 558 Annotation: Subtype: Link Rect: 317, 544, 552, 550 Annotation: Subtype: Link Rect: 317, 536, 552, 542 Annotation: Subtype: Link Rect: 317, 528, 552, 534 Annotation: Subtype: Link Rect: 317, 520, 355, 526 Annotation: Subtype: Link Rect: 317, 512, 552, 518 Annotation: Subtype: Link Rect: 317, 504, 552, 510 Annotation: Subtype: Link Rect: 317, 496, 352, 502 Checksum: 13786967 Type: CRC32 Checksum: f2fd517ac728cec4ebe684c4a850cdeb Type: MD5 Checksum: 8d9175ee60a43775c07cd9c83bbdc78953fde212 Type: SHA-1