124b95ebfa1af001a570c3b657d7dc8c 270628.pdf cf6ab3ba82d643be8bd496f62e9709d750462fbd 270628.pdf 36d0c1642109789cd35897119b94110ce478850a3bc35fdf9db42cd8f4b35747 270628.pdf Title: Comorbidities at Diagnosis, Survival, and Cause of Death in Patients with Chronic Lymphocytic Leukemia: A Population-Based Study Subject: This study aimed to examine the prevalence of comorbidities in patients diagnosed with chronic lymphocytic leukemia (CLL), and to assess its influence on survival and cause-specific mortality at a population-based level. Incident CLL cases diagnosed in the Girona province (Spain) during 2008–2016 were extracted from the Girona Cancer Registry. Rai stage and presence of comorbidities at diagnosis, further categorized using the Charlson comorbidity index (CCI), were obtained from clinical records. Observed (OS) and relative survival (RS) were estimated and Cox’s proportional hazard models were used to explore the impact of comorbidity on mortality. Among the 400 cases included in the study, 380 (99.5%) presented at least one comorbidity at CLL diagnosis, with diabetes without end organ damage (21%) being the most common disease. 5-year OS and RS were 68.8 (95% CI: 64.4–73.6) and 99.5 (95% CI 3.13–106.0), respectively, which decreased markedly with increasing CCI, particularly in patients with CCI 3. Multivariate analysis identified no statistically significant association between the CCI and overall CLL-related or CLL-unrelated mortality. In conclusion, a high CCI score negatively influenced the OS and RS of CLL patients, yet its effect on mortality was statistically non-significant when also considering age and the Rai stage. Keywords: chronic lymphocytic leukemia; comorbidities; causes of death; survival; population-based Author: Alicia Villavicencio, Marta Solans, Lluís Zacarías-Pons, Anna Vidal, Montse Puigdemont, Josep Maria Roncero, Marc Saez and Rafael Marcos-Gragera Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jan 15 09:58:13 2021 CET ModDate: Fri Jan 15 10:00:14 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 908695 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YFNERV+VnURWPalladioL Type 1 Custom yes yes no 10 0 RMRUGP+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 WQKDKG+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 ZRHOTD+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 IKKWKP+CMSY10 Type 1 Builtin yes yes no 28 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 MOSBKF+URWPalladioL-BoldItal Type 1 Custom yes yes no 88 0 ONAHLH+TimesNewRoman,Bold CID TrueType Identity-H yes yes yes 98 0 ONAJLE+TimesNewRoman,Italic TrueType WinAnsi yes yes no 104 0 ONAIID+TimesNewRoman CID TrueType Identity-H yes yes yes 107 0 ONAIJF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 113 0 ONAIJH+PalatinoLinotype TrueType WinAnsi yes yes no 116 0 ONAIKI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 119 0 ONAHLH+TimesNewRoman,Bold CID TrueType Identity-H yes yes yes 130 0 ONAJLE+TimesNewRoman,Italic TrueType WinAnsi yes yes no 136 0 ONAIID+TimesNewRoman CID TrueType Identity-H yes yes yes 139 0 ONAIJF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 145 0 ONAIJH+PalatinoLinotype TrueType WinAnsi yes yes no 148 0 ONAIKI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 151 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:08:05 CEST RepresentationInformation: 270628.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-26 11:01:13 CEST Size: 908695 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 336 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Comorbidity Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Survival and Mortality Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Prevalence of Comorbidity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Comorbidity and Survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Comorbidity and Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Info: Title: Comorbidities at Diagnosis, Survival, and Cause of Death in Patients with Chronic Lymphocytic Leukemia: A Population-Based Study Author: Alicia Villavicencio, Marta Solans, Lluís Zacarías-Pons, Anna Vidal, Montse Puigdemont, Josep Maria Roncero, Marc Saez and Rafael Marcos-Gragera Subject: This study aimed to examine the prevalence of comorbidities in patients diagnosed with chronic lymphocytic leukemia (CLL), and to assess its influence on survival and cause-specific mortality at a population-based level. Incident CLL cases diagnosed in the Girona province (Spain) during 2008 2016 were extracted from the Girona Cancer Registry. Rai stage and presence of comorbidities at diagnosis, further categorized using the Charlson comorbidity index (CCI), were obtained from clinical records. Observed (OS) and relative survival (RS) were estimated and Cox’s proportional hazard models were used to explore the impact of comorbidity on mortality. Among the 400 cases included in the study, 380 (99.5%) presented at least one comorbidity at CLL diagnosis, with diabetes without end organ damage (21%) being the most common disease. 5-year OS and RS were 68.8 (95% CI: 64.4 73.6) and 99.5 (95% CI 3.13 106.0), respectively, which decreased markedly with increasing CCI, particularly in patients with CCI 3. Multivariate analysis identified no statistically significant association between the CCI and overall CLL-related or CLL-unrelated mortality. In conclusion, a high CCI score negatively influenced the OS and RS of CLL patients, yet its effect on mortality was statistically non-significant when also considering age and the Rai stage. 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