0132cc5cf77fe36f33e2594636a1d6d5 270646.pdf 2084d91e5a5451fa94bb80eed3efdae634b3be2e 270646.pdf 05002aa6109b216cad598a441c0f9a654293a193f80dd075f039cd3c1f39f315 270646.pdf Title: Differences in the Impact of COVID-19 on Pathology Laboratories and Cancer Diagnosis in Girona Subject: Introduction: The recent COVID-19 pandemic has compromised socio-health care, with consequences for the diagnosis and follow-up of other pathologies. The aim of this study was to evaluate the impact of COVID-19 on cancer diagnosis in Girona, Spain. Methodology: Observational study of samples received in two pathology laboratories during 2019–2020 (tertiary hospital in Girona and county hospital in Figueres). Date, sample type, and location and morphology were available. Samples were recoded to determine malignancy and grouped by location. Comparisons were made by calendar year and period of exposure to COVID-19. Results: 102,360 samples were included: 80,517 from Girona and 21,843 from Figueres. The reduction in activity in the pathology laboratories in 2020 compared to the previous year was 25.4% in Girona and 27.5% in Figueres. The reduction in cancer diagnoses in 2020 compared to 2019 was 6.8% in Girona and 21% in Figueres. In both laboratories, a decrease was observed in the diagnoses of neoplasms of the lip, oral cavity and pharynx, larynx, colon, rectum and anus, kidney and urinary system, melanoma, and central nervous system. A statistically significant higher probability of a sample received in the pathology laboratory displaying malignancy during COVID-19 was found (Girona: OR = 1.28, 95% CI: 1.23–1.34; Figueres: OR = 1.10, 95% CI: 1.01–1.20) with respect to the COVID-19-free period. Conclusions: The COVID-19 pandemic has resulted in a reduction in cancer diagnoses by pathology departments that varies according to tumor location and type of hospital. Despite this, the optimization of care resources and the recovery effort have partially reduced the impact of the pandemic in certain neoplasms. Keywords: COVID-19; cancer; pathology; diagnosis Author: Arantza Sanvisens, Montse Puigdemont, Jordi Rubió-Casadevall, Anna Vidal-Vila, Eugeni López-Bonet, Ferran Martín-Romero and Rafael Marcos-Gragera Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Dec 16 10:28:17 2021 CET ModDate: Thu Dec 16 10:30:21 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1150570 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SDIDBK+VnURWPalladioL Type 1 Custom yes yes no 10 0 RENLZQ+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 PDUQRQ+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 QMOEUD+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 YWWVQQ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 95 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 99 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 103 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 107 0 FXXUVH+CMSY10 Type 1 Builtin yes yes no 122 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 130 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 134 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 138 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 142 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 162 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:07:36 CEST RepresentationInformation: 270646.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-26 16:59:12 CEST Size: 1150570 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 304 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Methodology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Info: Title: Differences in the Impact of COVID-19 on Pathology Laboratories and Cancer Diagnosis in Girona Author: Arantza Sanvisens, Montse Puigdemont, Jordi Rubió-Casadevall, Anna Vidal-Vila, Eugeni López-Bonet, Ferran Martín-Romero and Rafael Marcos-Gragera Subject: Introduction: The recent COVID-19 pandemic has compromised socio-health care, with consequences for the diagnosis and follow-up of other pathologies. The aim of this study was to evaluate the impact of COVID-19 on cancer diagnosis in Girona, Spain. Methodology: Observational study of samples received in two pathology laboratories during 2019 2020 (tertiary hospital in Girona and county hospital in Figueres). Date, sample type, and location and morphology were available. Samples were recoded to determine malignancy and grouped by location. Comparisons were made by calendar year and period of exposure to COVID-19. Results: 102,360 samples were included: 80,517 from Girona and 21,843 from Figueres. The reduction in activity in the pathology laboratories in 2020 compared to the previous year was 25.4% in Girona and 27.5% in Figueres. The reduction in cancer diagnoses in 2020 compared to 2019 was 6.8% in Girona and 21% in Figueres. In both laboratories, a decrease was observed in the diagnoses of neoplasms of the lip, oral cavity and pharynx, larynx, colon, rectum and anus, kidney and urinary system, melanoma, and central nervous system. A statistically significant higher probability of a sample received in the pathology laboratory displaying malignancy during COVID-19 was found (Girona: OR = 1.28, 95% CI: 1.23 1.34; Figueres: OR = 1.10, 95% CI: 1.01 1.20) with respect to the COVID-19-free period. Conclusions: The COVID-19 pandemic has resulted in a reduction in cancer diagnoses by pathology departments that varies according to tumor location and type of hospital. Despite this, the optimization of care resources and the recovery effort have partially reduced the impact of the pandemic in certain neoplasms. 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