269403f48a4eb392a6ea08c6d4b4006b 270662.pdf 3b930d1fc2dfb6c6a2632ecd7af79327232cfe53 270662.pdf aa7129e4aa9eadccb3ff41172fcf332bbce9e83d7eaf601fdbbc3d00e360feb7 270662.pdf Title: DNA methylation biomarkers of myocardial infarction and cardiovascular disease Subject: Clinical Epigenetics, https://doi.org/10.1186/s13148-021-01078-6 Keywords: DNA methylation;Epigenome-wide association study;Predictive biomarkers;Myocardial infarction;Cardiovascular disease Author: Alba Fernández-Sanlés Creator: Adobe InDesign 15.0 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Apr 20 09:25:03 2021 CEST ModDate: Wed Apr 21 13:34:13 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1163745 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 34 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 41 0 MyriadPro-It Type 1C Custom yes no yes 36 0 WarnockPro-Regular Type 1C Custom yes no yes 35 0 MyriadPro-Semibold Type 1C Custom yes no yes 40 0 MyriadPro-Light Type 1C Custom yes no yes 38 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 39 0 DAELAD+MTSY Type 1C Custom yes yes yes 37 0 WarnockPro-It Type 1C Custom yes no yes 42 0 MyriadPro-SemiboldIt Type 1C Custom yes no yes 43 0 MyriadPro-Regular2 Type 1C WinAnsi yes no yes 210 0 MyriadPro-Regular3 Type 1C WinAnsi yes no yes 178 0 UZYZBZ+OpenSans-Light Type 1C Custom yes yes no 185 0 UZYZBZ+OpenSans-Extrabold Type 1C WinAnsi yes yes no 181 0 UZYZBZ+OregonLDOBookSinistral Type 1C WinAnsi yes yes no 191 0 UZYZBZ+OpenSans-Bold Type 1C WinAnsi yes yes no 188 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-24 02:31:10 CEST RepresentationInformation: 270662.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-23 14:14:01 CEST Size: 1163745 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 386 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: DNA methylation biomarkers of myocardial infarction and cardiovascular disease Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Results: Item: Title: Conclusions: Item: Title: Introduction Item: Title: Results Children: Item: Title: Quality control of DNA methylation data, cardiovascular outcomes and covariates Item: Title: Association between DNA methylation and cardiovascular outcomes Children: Item: Title: Two-stage EWAS on acute myocardial infarction Children: Item: Title: Discovery stage Item: Title: Validation and meta-analysis Item: Title: Follow-up association studies on incident CHD and CVD events Item: Title: Association between the identified CpGs and CVRFs Item: Title: Association between MRSs and incidence of CHD and CVD Item: Title: Causality of the associations between DNA methylation and cardiovascular outcomes Item: Title: Discussion Children: Item: Title: CpG sites associated with acute MI events Item: Title: CpG sites consistently related to prevalent and incident CVD events Item: Title: MRSs as predictive CVD biomarkers Item: Title: Causality of the associations between methylation loci and cardiovascular outcomes Item: Title: Strengths and limitations Item: Title: Conclusion Item: Title: Methods Children: Item: Title: Study design and populations Children: Item: Title: Case–control studies of acute MI in REGICOR Item: Title: Samples with incident cases of CHD and CVD Item: Title: Assessment of cardiovascular outcomes Item: Title: Assessment of DNA methylation Item: Title: Covariates Item: Title: Statistical analysis Children: Item: Title: Association between DNA methylation and cardiovascular outcomes Item: Title: Association between the identified CpGs and CVRFs Item: Title: Methylation risk scores (MRSs) and predictive capacity Item: Title: Causality of associations between DNA methylation and cardiovascular outcomes Item: Title: Acknowledgements Item: Title: References Info: Title: DNA methylation biomarkers of myocardial infarction and cardiovascular disease Author: Alba Fernández-Sanlés Subject: Clinical Epigenetics, https://doi.org/10.1186/s13148-021-01078-6 Keywords: DNA methylation;Epigenome-wide association study;Predictive biomarkers;Myocardial infarction;Cardiovascular disease Creator: Adobe InDesign 15.0 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Apr 20 09:25:03 CEST 2021 ModDate: Wed Apr 21 13:34:13 CEST 2021 ID: 0x19466126ec5cf147547b483e5789d80f, 0xe1133e3557bf0a264a2d77d3149ccc40 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 74 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 629 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1082 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DAELAD+MTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: DAELAD+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2021-04-20T07:25:03 Adobe InDesign 15.0 (Windows) 2021-04-21T13:34:13+02:00 2021-04-21T13:34:13+02:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) DNA methylation;Epigenome-wide association study;Predictive biomarkers;Myocardial infarction;Cardiovascular disease False application/pdf https://doi.org/10.1186/s13148-021-01078-6 BioMed Central Clinical Epigenetics, https://doi.org/10.1186/s13148-021-01078-6 DNA methylation Epigenome-wide association study Predictive biomarkers Myocardial infarction Cardiovascular disease DNA methylation biomarkers of myocardial infarction and cardiovascular disease Alba Fernández-Sanlés Sergi Sayols-Baixeras Isaac Subirana Mariano Sentí S. Pérez-Fernández Manuel Castro de Moura Manel Esteller Jaume Marrugat Roberto Elosua 10.1186/s13148-021-01078-6 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s13148-021-01078-6 10.1186/s13148-021-01078-6 1868-7083 journal Clinical Epigenetics The Author(s) 2010-04-23 true 10.1186/s13148-021-01078-6 noindex springer.com springerlink.com uuid:9f8dec13-5c63-4347-85d3-9ec2b60072ab uuid:7190c80a-1467-492b-942c-c86a6abf1d6b default 1 converted uuid:9f8dec13-5c63-4347-85d3-9ec2b60072ab converted to PDF/A-2b pdfToolbox 2021-04-20T07:53:16Z 2 B Roberto Elosua http://orcid.org/0000-0001-8235-0095 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 448, 598, 460, 586 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 212, 66, 330, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 66, 530, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 58, 276, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 255, 250, 260, 238 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 266, 250, 271, 238 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 175, 226, 180, 214 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 439, 275, 444, 262 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 501, 227, 506, 214 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 413, 143, 418, 130 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 83, 668, 88, 656 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 208, 668, 212, 656 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 218, 668, 228, 656 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 85, 548, 94, 536 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 200, 476, 209, 464 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 268, 212, 273, 200 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 56, 200, 61, 188 Flags: Print AppearanceDictionary: true Destination: 45 Annotation: Subtype: Link Rect: 244, 164, 248, 152 Flags: Print AppearanceDictionary: true Destination: 45 Annotation: Subtype: Link Rect: 469, 238, 474, 226 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 367, 226, 371, 214 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 531, 214, 536, 202 Flags: Print AppearanceDictionary: true Destination: 146 Thumb: true Page: Sequence: 3 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 84, 669, 89, 656 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 172, 669, 177, 656 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 148, 513, 152, 500 Flags: Print AppearanceDictionary: true Destination: 105 Annotation: Subtype: Link Rect: 217, 513, 222, 500 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 83, 477, 88, 464 Flags: Print AppearanceDictionary: true Destination: 109 Annotation: Subtype: Link Rect: 161, 369, 166, 356 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 71, 285, 76, 272 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 236, 153, 246, 140 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 159, 105, 164, 92 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 307, 512, 312, 500 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 307, 500, 312, 488 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 386, 296, 396, 284 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 401, 296, 411, 284 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 440, 224, 449, 212 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 307, 128, 317, 116 Flags: Print AppearanceDictionary: true Destination: 159 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 110, 380, 119, 368 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 126, 380, 136, 368 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 77, 356, 87, 344 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 127, 344, 137, 332 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 206, 284, 216, 272 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 208, 212, 218, 200 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 275, 200, 285, 188 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 151, 164, 161, 152 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 238, 152, 247, 140 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 82, 91, 92, 78 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 405, 451, 415, 439 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 422, 451, 432, 439 Flags: Print AppearanceDictionary: true Destination: 159 Thumb: true Page: Sequence: 7 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 380, 383, 502, 371 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 299, 536, 287 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 531, 167, 536, 155 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 356, 143, 366, 131 Flags: Print AppearanceDictionary: true Destination: 159 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 122, 705, 127, 692 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 275, 657, 285, 644 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 158, 621, 168, 608 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 177, 537, 290, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 525, 129, 512 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 228, 513, 233, 500 Flags: Print AppearanceDictionary: true Destination: 146 Annotation: Subtype: Link Rect: 228, 309, 238, 296 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 242, 273, 251, 260 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 257, 273, 267, 260 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 523, 417, 533, 405 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 424, 309, 434, 297 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 413, 249, 423, 237 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 348, 237, 358, 225 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 486, 213, 496, 201 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 365, 189, 370, 177 Flags: Print AppearanceDictionary: true Destination: 146 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 248, 689, 281, 681 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 680, 156, 672 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 372, 361, 534, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 334, 477, 326 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 515, 316, 537, 308 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 319, 307, 402, 299 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 3cccf5ab Type: CRC32 Checksum: 269403f48a4eb392a6ea08c6d4b4006b Type: MD5 Checksum: 3b930d1fc2dfb6c6a2632ecd7af79327232cfe53 Type: SHA-1