2f073298a0072cd197cc3d2bbeef83fe 271472.pdf c6161a489fe30f83a0d6be39ffc48e0e79550408 271472.pdf 6a248e38df65f4c677ab5f28eb42ab4c49a6c4bf59befcbe9cf6d1275e201f4c 271472.pdf Title: Fragility of randomized trials supporting cancer drug approvals stratified by approval pathway and review designations Subject: Cancer Medicine 2021.10:5405-5414 Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT CreationDate: Sat Aug 14 09:48:15 2021 CEST ModDate: Tue Feb 14 13:12:50 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 336596 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RQTQIQ+STIX-Italic Type 1C WinAnsi yes yes yes 50 0 NAMNEY+STIX-Bold Type 1C Custom yes yes yes 39 0 VEPOMI+STIX-Regular Type 1C Custom yes yes yes 40 0 Times-Roman Type 1 WinAnsi no no no 2 0 ROFNIQ+STIX-Regular-SC700 Type 1C WinAnsi yes yes yes 153 0 ROFNIQ+STIX-Regular-SC700 Type 1C WinAnsi yes yes yes 157 0 JCMPAG+Calibri Type 1C Custom yes yes no 59 0 IDXJMI+STIX-BoldItalic Type 1C WinAnsi yes yes yes 80 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:06:34 CEST RepresentationInformation: 271472.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:06 CEST Size: 336596 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Language: en-US Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1383 ImageHeight: 979 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: IDXJMI+STIX-BoldItalic FontSubset: true FirstChar: 112 LastChar: 112 FontDescriptor: FontName: IDXJMI+STIX-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -753, -359, 1430, 1004 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RQTQIQ+STIX-Italic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RQTQIQ+STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NAMNEY+STIX-Bold FontSubset: true FirstChar: 31 LastChar: 177 FontDescriptor: FontName: NAMNEY+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VEPOMI+STIX-Regular FontSubset: true FirstChar: 29 LastChar: 246 FontDescriptor: FontName: VEPOMI+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JCMPAG+Calibri FontSubset: true FirstChar: 30 LastChar: 121 FontDescriptor: FontName: JCMPAG+Calibri Flags: Nonsymbolic FontBBox: -503, -307, 1240, 964 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-08-16T08:08:03+05:30 2023-02-14T04:12:50-08:00 2023-02-14T04:12:50-08:00 Acrobat Distiller 10.1.7 (Windows) 10.1002/cam4.4029 10.1002/(ISSN)2045-7634 3 VoR 10.1002/cam4.4029 application/pdf Fragility of randomized trials supporting cancer drug approvals stratified by approval pathway and review designations uuid:18181f6a-98f7-4d7c-9d97-a3c3edd40d46 uuid:1067c946-c25a-41d8-9c19-8c5725001b1c Adobe PDF Library 15.0; 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