d01e526cd4d878c09392598bb32b142f 271479.pdf 0018d26fae92b07f845cbbebec9b27cf089b0961 271479.pdf 667aca620619c9611aaf6b17b572cf6ddbb4a4729a15f5a4ccad066ea494b3af 271479.pdf Title: Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies Subject: Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease. Keywords: reverse cholesterol transport; HDL; fatty acids; sterols; rodents Author: Bianca Papotti, Joan Carles Escolà-Gil, Josep Julve, Francesco Potì and Ilaria Zanotti Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Aug 3 09:52:29 2021 CEST ModDate: Tue Aug 3 09:56:10 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2211131 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZZGWQU+VnURWPalladioL Type 1 Custom yes yes no 10 0 OMVIXM+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 QEVJJH+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 ITFXDN+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 RTVXVB+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 NYWBCD+EURB10 Type 1 Builtin yes yes no 81 0 EBRYJC+EURM10 Type 1 Builtin yes yes no 88 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 113 0 JTLWKN+CMSY10 Type 1 Builtin yes yes no 120 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:06:15 CEST RepresentationInformation: 271479.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:06 CEST Size: 2211131 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 815 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Implications of the Reverse Cholesterol Transport in Cardiovascular Disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: General Aspects of Dietary Lipids: Chemistry, Sources, Intake, and Effect on CVD in Humans Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Fatty Acids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Sterols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Other Lipids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Effects of SFA on RCT in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Effects of MUFA on RCT in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Effects of PUFA on RCT in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Effects of TFA on RCT in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Effects of Sterols on RCT in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Effects of Other Lipids on RCT in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Info: Title: Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies Author: Bianca Papotti, Joan Carles Escolà-Gil, Josep Julve, Francesco Potì and Ilaria Zanotti Subject: Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease. 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