41f003461d590524aea314008bdc148e 271484.pdf 8f48bcb791aac7d97b10f1d6e6e6dc86d72c15b8 271484.pdf aafa825fb340cd766cce3b4bce672f8017d4d4d948f4917cc847baedde75ee5c 271484.pdf Title: Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome Subject: Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19. Keywords: down syndrome; COVID-19; SARS-CoV-2; pneumonia Author: Diego Real de Asua, Miguel A. Mayer, María del Carmen Ortega, Jose M. Borrel, Teresa de Jesús Bermejo, Domingo González-Lamuño, Coral Manso, Fernando Moldenhauer, María Carmona-Iragui, Anke Hüls, Stephanie L. Sherman, Andre Strydom, Rafael de la Torre, Mara Dierssen and on behalf of the Spanish Trisomy 21 Research Society COVID-19 Taskforce Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Aug 24 08:50:40 2021 CEST ModDate: Tue Aug 24 09:01:54 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 729426 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JGBJTI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 TOVYVO+VnURWPalladioL Type 1 Custom yes yes no 15 0 VNDXHS+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 CNICLK+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 VGZBFI+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 FPWQRR+VnURWPalladioL-Italic Type 1 Custom yes yes no 84 0 JLZORU+EURM10 Type 1 Builtin yes yes no 88 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 95 0 MKHHVF+EURB10 Type 1 Builtin yes yes no 102 0 JDUPKS+CMSY10 Type 1 Builtin yes yes no 106 0 KMEJHL+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 113 0 KMELLH+Arial CID TrueType Identity-H yes yes yes 119 0 KMEJHM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 125 0 KMEJIN+PalatinoLinotype CID TrueType Identity-H yes yes yes 128 0 KMEJIO+PalatinoLinotype TrueType WinAnsi yes yes no 134 0 KMEJJA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 137 0 KMELCI+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 140 0 KMEJHM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 149 0 KMEJIO+PalatinoLinotype TrueType WinAnsi yes yes no 152 0 KMEJJA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 155 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:06:02 CEST RepresentationInformation: 271484.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:07 CEST Size: 729426 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 287 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Data Extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Socio-Demographic and Clinical Characteristics of the Spanish DS COVID-19 Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Comparison of COVID-19 and Other Pneumonia-Related Hospitalizations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Mortality Rates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Info: Title: Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome Author: Diego Real de Asua, Miguel A. Mayer, María del Carmen Ortega, Jose M. Borrel, Teresa de Jesús Bermejo, Domingo González-Lamuño, Coral Manso, Fernando Moldenhauer, María Carmona-Iragui, Anke Hüls, Stephanie L. Sherman, Andre Strydom, Rafael de la Torre, Mara Dierssen and on behalf of the Spanish Trisomy 21 Research Society COVID-19 Taskforce Subject: Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19. 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