c4511f58eeca321b5799ff485c472a79 271492.pdf f69ef0d6f8125df0fcfd5cc4813cb3eb3fc7ac01 271492.pdf cdfc26350a0bbd45da2c6fdca61d7cf38281443c77e5db2c52ee0ad30218d3ac 271492.pdf Title: Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project Subject: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its prevalence is estimated to increase in the future. PD has a great impact on patients’ and caregivers’ lives and also entails a substantial socioeconomic burden. The aim of the present study was to examine the current situation and the 10-year PD forecast for Spain in order to optimize and design future management strategies. This study was performed using the modified Delphi method to try to obtain a consensus among a panel of movement disorders experts. According to the panel, future PD management will improve diagnostic capacity and follow-up, it will include multidisciplinary teams, and innovative treatments will be developed. The expansion of new technologies and studies on biomarkers will have an impact on future PD management, leading to more accurate diagnoses, prognoses, and individualized therapies. However, the socio-economic impact of the disease will continue to be significant by 2030, especially for patients in advanced stages. This study highlighted the unmet needs in diagnosis and treatment and how crucial it is to establish recommendations for future diagnostic and therapeutic management of PD. Keywords: diagnosis; economic impact; epidemiology; management; mortality; Parkinson’s disease; quality of life; Spain; treatment Author: Diego Santos García, Marta Blázquez-Estrada, Matilde Calopa, Francisco Escamilla-Sevilla, Eric Freire, Pedro J. García Ruiz, Francisco Grandas, Jaime Kulisevsky, Lydia López-Manzanares, Juan Carlos Martínez Castrillo, Pablo Mir, Javier Pagonabarraga, Francisco Pérez-Errazquin, José María Salom, Beatriz Tijero, Francesc Valldeoriola, Rosa Yáñez, Arantxa Avilés and María-Rosario Luquín Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Aug 5 13:09:02 2021 CEST ModDate: Thu Aug 5 13:16:21 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1960902 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IYDCBB+VnURWPalladioL Type 1 Custom yes yes no 10 0 YMZYPJ+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 BSSBQA+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 FDJOGA+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 SLUQMQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 81 0 EPRKOS+MSAM10 Type 1 Builtin yes yes no 88 0 CKBPVA+EURM10 Type 1 Builtin yes yes no 132 0 UJUUJI+PazoMath Type 1 Builtin yes yes no 139 0 NJWNDJ+VnURWPalladioL-Italic Type 1 Custom yes yes no 149 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:05:46 CEST RepresentationInformation: 271492.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:07 CEST Size: 1960902 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 298 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Panelists’ Description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Epidemiology of PD Etiopathogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Prognostic Factors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Medical Specialties Involved in the Management of the PD Patient Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Follow-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Impact of PD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Needs of Management Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Resource Availability and General Needs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project Author: Diego Santos García, Marta Blázquez-Estrada, Matilde Calopa, Francisco Escamilla-Sevilla, Eric Freire, Pedro J. García Ruiz, Francisco Grandas, Jaime Kulisevsky, Lydia López-Manzanares, Juan Carlos Martínez Castrillo, Pablo Mir, Javier Pagonabarraga, Francisco Pérez-Errazquin, José María Salom, Beatriz Tijero, Francesc Valldeoriola, Rosa Yáñez, Arantxa Avilés and María-Rosario Luquín Subject: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000 150.000 individuals, and its prevalence is estimated to increase in the future. PD has a great impact on patients’ and caregivers’ lives and also entails a substantial socioeconomic burden. The aim of the present study was to examine the current situation and the 10-year PD forecast for Spain in order to optimize and design future management strategies. This study was performed using the modified Delphi method to try to obtain a consensus among a panel of movement disorders experts. According to the panel, future PD management will improve diagnostic capacity and follow-up, it will include multidisciplinary teams, and innovative treatments will be developed. The expansion of new technologies and studies on biomarkers will have an impact on future PD management, leading to more accurate diagnoses, prognoses, and individualized therapies. However, the socio-economic impact of the disease will continue to be significant by 2030, especially for patients in advanced stages. This study highlighted the unmet needs in diagnosis and treatment and how crucial it is to establish recommendations for future diagnostic and therapeutic management of PD. Keywords: diagnosis; economic impact; epidemiology; management; mortality; Parkinson’s disease; quality of life; Spain; treatment Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Aug 05 13:09:02 CEST 2021 ModDate: Thu Aug 05 13:16:21 CEST 2021 ID: 0x02123c7c8129c506f5680ab91706cff5, 0x02123c7c8129c506f5680ab91706cff5 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: PDTLUH+CMSY10 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: PDTLUH+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: BSSBQA+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: BSSBQA+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CKBPVA+EURM10 FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: CKBPVA+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: NJWNDJ+VnURWPalladioL-Italic FontSubset: true FirstChar: 189 LastChar: 226 FontDescriptor: FontName: NJWNDJ+VnURWPalladioL-Italic Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FDJOGA+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: FDJOGA+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EPRKOS+MSAM10 FontSubset: true FirstChar: 72 LastChar: 78 FontDescriptor: FontName: EPRKOS+MSAM10 Flags: Symbolic FontBBox: 8, -463, 1331, 1003 FontFile: true Font: BaseFont: IYDCBB+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 243 FontDescriptor: FontName: IYDCBB+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UJUUJI+PazoMath FontSubset: true FirstChar: 160 LastChar: 160 FontDescriptor: FontName: UJUUJI+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true Font: BaseFont: JYPLJJ+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 226 FontDescriptor: FontName: JYPLJJ+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YMZYPJ+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: YMZYPJ+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 35, 759, 174, 795 Annotation: Subtype: Link Rect: 515, 759, 560, 795 Annotation: Subtype: Link Rect: 141, 659, 152, 673 Annotation: Subtype: Link Rect: 271, 659, 282, 673 Annotation: Subtype: Link Rect: 497, 659, 508, 673 Annotation: Subtype: Link Rect: 183, 635, 195, 648 Annotation: Subtype: Link Rect: 138, 358, 154, 367 Annotation: Subtype: Link Rect: 35, 346, 154, 355 Annotation: Subtype: Link Rect: 35, 336, 89, 343 Annotation: Subtype: Link Rect: 35, 162, 97, 184 Annotation: Subtype: Link Rect: 153, 89, 154, 98 Annotation: Subtype: Link Rect: 35, 77, 147, 86 Annotation: Subtype: Link Rect: 121, 17, 273, 28 Annotation: Subtype: Link Rect: 406, 17, 558, 28 Annotation: Subtype: Link Rect: 35, 470, 87, 489 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 284, 543, 291, 552 ActionDest: 146 Annotation: Subtype: Link Rect: 549, 543, 556, 552 ActionDest: 146 Annotation: Subtype: Link Rect: 363, 505, 370, 514 ActionDest: 146 Annotation: Subtype: Link Rect: 187, 492, 194, 501 ActionDest: 146 Annotation: Subtype: Link Rect: 385, 480, 392, 489 ActionDest: 146 Annotation: Subtype: Link Rect: 511, 442, 518, 451 ActionDest: 146 Annotation: Subtype: Link Rect: 519, 442, 526, 451 ActionDest: 146 Annotation: Subtype: Link Rect: 310, 405, 317, 414 ActionDest: 146 Annotation: Subtype: Link Rect: 317, 405, 324, 414 ActionDest: 146 Annotation: Subtype: Link Rect: 271, 367, 278, 376 ActionDest: 146 Annotation: Subtype: Link Rect: 420, 317, 432, 326 ActionDest: 146 Annotation: Subtype: Link Rect: 526, 304, 537, 313 ActionDest: 146 Annotation: Subtype: Link Rect: 329, 204, 336, 213 ActionDest: 146 Annotation: Subtype: Link Rect: 269, 141, 281, 150 ActionDest: 146 Annotation: Subtype: Link Rect: 306, 128, 318, 137 ActionDest: 146 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 330, 622, 342, 631 ActionDest: 153 Annotation: Subtype: Link Rect: 345, 621, 357, 631 ActionDest: 153 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 524, 415, 531, 426 ActionDest: 85 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 200, 654, 207, 666 ActionDest: 92 Annotation: Subtype: Link Rect: 203, 302, 210, 311 ActionDest: 146 Annotation: Subtype: Link Rect: 211, 302, 218, 311 ActionDest: 146 Annotation: Subtype: Link Rect: 493, 299, 500, 311 ActionDest: 98 Annotation: Subtype: Link Rect: 536, 237, 543, 249 ActionDest: 98 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 509, 373, 516, 385 ActionDest: 98 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 226, 438, 234, 450 ActionDest: 101 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 549, 143, 556, 154 ActionDest: 101 Annotation: Subtype: Link Rect: 549, 93, 556, 104 ActionDest: 101 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 384, 720, 391, 732 ActionDest: 101 Annotation: Subtype: Link Rect: 195, 658, 202, 669 ActionDest: 101 Annotation: Subtype: Link Rect: 289, 481, 296, 493 ActionDest: 110 Annotation: Subtype: Link Rect: 294, 419, 301, 430 ActionDest: 110 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 200, 207, 207, 219 ActionDest: 113 Annotation: Subtype: Link Rect: 252, 145, 259, 157 ActionDest: 113 Annotation: Subtype: Link Rect: 294, 107, 301, 119 ActionDest: 113 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 194, 93, 201, 105 ActionDest: 123 Annotation: Subtype: Link Rect: 531, 68, 538, 80 ActionDest: 123 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 485, 89, 492, 101 ActionDest: 126 Page: Sequence: 13 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 195, 695, 202, 706 ActionDest: 126 Annotation: Subtype: Link Rect: 503, 609, 510, 618 ActionDest: 146 Annotation: Subtype: Link Rect: 192, 571, 198, 580 ActionDest: 146 Annotation: Subtype: Link Rect: 543, 534, 555, 543 ActionDest: 153 Annotation: Subtype: Link Rect: 501, 508, 508, 518 ActionDest: 146 Annotation: Subtype: Link Rect: 470, 446, 482, 455 ActionDest: 153 Annotation: Subtype: Link Rect: 227, 433, 234, 442 ActionDest: 146 Annotation: Subtype: Link Rect: 479, 358, 491, 367 ActionDest: 153 Annotation: Subtype: Link Rect: 494, 358, 506, 367 ActionDest: 153 Annotation: Subtype: Link Rect: 483, 295, 495, 304 ActionDest: 153 Annotation: Subtype: Link Rect: 204, 195, 216, 204 ActionDest: 153 Annotation: Subtype: Link Rect: 201, 119, 212, 128 ActionDest: 146 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 245, 722, 257, 731 ActionDest: 153 Annotation: Subtype: Link Rect: 258, 722, 270, 731 ActionDest: 153 Annotation: Subtype: Link Rect: 442, 672, 454, 681 ActionDest: 153 Annotation: Subtype: Link Rect: 224, 509, 236, 518 ActionDest: 153 Annotation: Subtype: Link Rect: 239, 509, 251, 518 ActionDest: 153 Annotation: Subtype: Link Rect: 387, 471, 399, 480 ActionDest: 153 Annotation: Subtype: Link Rect: 525, 408, 537, 417 ActionDest: 153 Annotation: Subtype: Link Rect: 229, 383, 241, 392 ActionDest: 153 Annotation: Subtype: Link Rect: 244, 258, 256, 267 ActionDest: 153 Annotation: Subtype: Link Rect: 359, 208, 371, 217 ActionDest: 153 Annotation: Subtype: Link Rect: 247, 170, 259, 179 ActionDest: 146 Annotation: Subtype: Link Rect: 544, 95, 556, 104 ActionDest: 153 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 424, 303, 560, 314 Annotation: Subtype: Link Rect: 166, 291, 285, 302 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 301, 362, 338, 373 Annotation: Subtype: Link Rect: 200, 339, 413, 350 Annotation: Subtype: Link Rect: 172, 281, 209, 292 Annotation: Subtype: Link Rect: 215, 281, 251, 292 Annotation: Subtype: Link Rect: 446, 270, 484, 281 Annotation: Subtype: Link Rect: 490, 270, 526, 281 Annotation: Subtype: Link Rect: 376, 258, 413, 269 Annotation: Subtype: Link Rect: 59, 224, 97, 235 Annotation: Subtype: Link Rect: 103, 224, 139, 235 Annotation: Subtype: Link Rect: 392, 178, 429, 189 Annotation: Subtype: Link Rect: 322, 143, 359, 154 Annotation: Subtype: Link Rect: 311, 86, 348, 97 Annotation: Subtype: Link Rect: 325, 63, 363, 74 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 59, 710, 97, 720 Annotation: Subtype: Link Rect: 86, 652, 322, 663 Annotation: Subtype: Link Rect: 330, 630, 367, 640 Annotation: Subtype: Link Rect: 373, 630, 409, 640 Annotation: Subtype: Link Rect: 470, 606, 508, 617 Annotation: Subtype: Link Rect: 59, 584, 97, 594 Annotation: Subtype: Link Rect: 519, 560, 557, 571 Annotation: Subtype: Link Rect: 59, 549, 95, 559 Annotation: Subtype: Link Rect: 59, 526, 97, 536 Annotation: Subtype: Link Rect: 309, 503, 346, 513 Annotation: Subtype: Link Rect: 454, 479, 492, 490 Annotation: Subtype: Link Rect: 412, 456, 449, 467 Annotation: Subtype: Link Rect: 456, 456, 492, 467 Annotation: Subtype: Link Rect: 368, 445, 405, 456 Annotation: Subtype: Link Rect: 412, 445, 448, 456 Annotation: Subtype: Link Rect: 170, 411, 207, 421 Annotation: Subtype: Link Rect: 214, 411, 250, 421 Annotation: Subtype: Link Rect: 311, 388, 348, 398 Annotation: Subtype: Link Rect: 327, 353, 364, 364 Annotation: Subtype: Link Rect: 381, 318, 419, 329 Annotation: Subtype: Link Rect: 425, 318, 461, 329 Annotation: Subtype: Link Rect: 443, 295, 481, 306 Annotation: Subtype: Link Rect: 487, 295, 523, 306 Annotation: Subtype: Link Rect: 95, 273, 132, 283 Annotation: Subtype: Link Rect: 139, 273, 175, 283 Annotation: Subtype: Link Rect: 282, 249, 320, 260 Annotation: Subtype: Link Rect: 234, 226, 560, 237 Annotation: Subtype: Link Rect: 56, 215, 251, 226 Annotation: Subtype: Link Rect: 170, 192, 207, 203 Annotation: Subtype: Link Rect: 127, 158, 165, 168 Checksum: 2c5e9e5b Type: CRC32 Checksum: c4511f58eeca321b5799ff485c472a79 Type: MD5 Checksum: f69ef0d6f8125df0fcfd5cc4813cb3eb3fc7ac01 Type: SHA-1