538c9e191e156acb2dfc0a3277837a87 271923.pdf 781ea26c84cc13d0fd6fad3dc365f86918071420 271923.pdf 7a1602cf51ad23ff553a9f0fc2c1211ddde3f1b3d3f16720a827824584ba123c 271923.pdf Title: A multicentre validation study of the diagnostic value of plasma neurofilament light Subject: Nature Communications, doi:10.1038/s41467-021-23620-z Keywords: Author: Nicholas J. Ashton Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat May 29 13:30:21 2021 CEST ModDate: Tue Jun 1 17:30:23 2021 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2079449 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GPGPMP+AdvOTf23bb480+fb Type 1C Custom yes yes yes 711 0 GPGPJN+AdvOTcb88df00 Type 1C WinAnsi yes yes no 89 0 GPGPNA+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 90 0 Arial-BoldMT Type 1C WinAnsi yes no no 712 0 GPGPLO+AdvOTf23bb480 Type 1C WinAnsi yes yes no 713 0 GPGNPB+AdvOTea1a7398 Type 1C WinAnsi yes yes no 93 0 GPGOCB+AdvOTea1a7398+fb Type 1C Custom yes yes yes 152 0 GPGODC+AdvTT2876772e+27 Type 1C Custom yes yes yes 388 0 GPGPJK+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 153 0 GPGPJL+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 130 0 GPGPJM+AdvTTab7e17fd Type 1C WinAnsi yes yes no 100 0 GPHAAG+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 91 0 GPHABH+AdvTTab7e17fd+22 Type 1C Custom yes yes no 92 0 GPHAAE+AdvOT1ef757c0+20 Type 1C Custom yes yes yes 94 0 GPHAAF+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 95 0 GPHAAC+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 96 0 GPHAAD+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 97 0 GPGPPA+AdvOT125c650c Type 1C WinAnsi yes yes no 98 0 GPHAAB+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 99 0 GPHACI+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 128 0 GPHACH+AdvOT8b40f9c2.B+03 Type 1C Custom yes yes yes 129 0 GPHFBL+AdvOTcb88df00+20 Type 1C WinAnsi yes yes no 151 0 GPICCM+AdvOT1ef757c0+21 Type 1C WinAnsi yes yes no 308 0 GPICGL+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 369 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:03:34 CEST RepresentationInformation: 271923.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:12 CEST Size: 2079449 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR63' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR64' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR65' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR49' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR66' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR67' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR68' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 1470711 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 1470711 MIMEtype: application/pdf PDFMetadata: Objects: 842 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: A multicentre validation study of the diagnostic value of plasma neurofilament light Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Plasma NfL concentrations in cognitively unimpaired and neurodegenerative disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Accuracy of plasma NfL in differentiating neurodegenerative disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Concentration cutoff points for neurodegeneration using plasma NfL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Study participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Determination of amyloid-β status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Biochemical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Harmonization of KCL and Lund cohorts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Info: Title: A multicentre validation study of the diagnostic value of plasma neurofilament light Author: Nicholas J. Ashton Subject: Nature Communications, doi:10.1038/s41467-021-23620-z Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat May 29 14:00:21 CEST 2021 ModDate: Tue Jun 01 17:30:23 CEST 2021 ID: 0x1a54e3e0273f4f852cb3c1d5625009e0, 0xcdb4df540f97490a632d1e136ac91cdd Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 801 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 475 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1791 ImageHeight: 488 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2000 ImageHeight: 780 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2006 ImageHeight: 983 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2000 ImageHeight: 1017 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: GPHAAC+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GPHAAC+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPHACI+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GPHACI+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPHAAD+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GPHAAD+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPHACH+AdvOT8b40f9c2.B+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GPHACH+AdvOT8b40f9c2.B+03 Flags: Symbolic FontBBox: -500, -416, 916, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPGPJL+AdvOT9bd21c25.I FontSubset: true FirstChar: 103 LastChar: 110 FontDescriptor: FontName: GPGPJL+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGPPA+AdvOT125c650c FontSubset: true FirstChar: 73 LastChar: 73 FontDescriptor: FontName: GPGPPA+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPHAAB+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: GPHAAB+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGPJM+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: GPGPJM+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGODC+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GPGODC+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPGPMP+AdvOTf23bb480+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GPGPMP+AdvOTf23bb480+fb Flags: Symbolic FontBBox: 0, -197, 718, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGPLO+AdvOTf23bb480 FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: GPGPLO+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPICGL+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: GPICGL+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPICCM+AdvOT1ef757c0+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: GPICCM+AdvOT1ef757c0+21 Flags: Nonsymbolic FontBBox: 0, -20, 822, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPHFBL+AdvOTcb88df00+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: GPHFBL+AdvOTcb88df00+20 Flags: Nonsymbolic FontBBox: -104, -197, 864, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGOCB+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GPGOCB+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPGPJN+AdvOTcb88df00 FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: GPGPJN+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGPJK+AdvOTea1a7398+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: GPGPJK+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPGPNA+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: GPGPNA+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPHAAG+AdvOTb65e897d.B FontSubset: true FirstChar: 48 LastChar: 121 FontDescriptor: FontName: GPHAAG+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPHABH+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: GPHABH+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GPGNPB+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: GPGNPB+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GPHAAE+AdvOT1ef757c0+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: GPHAAE+AdvOT1ef757c0+20 Flags: Symbolic FontBBox: -135, -187, 1010, 833 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GPHAAF+AdvOT7d6df7ab.I FontSubset: true FirstChar: 46 LastChar: 122 FontDescriptor: FontName: GPHAAF+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-021-23620-z A multicentre validation study of the diagnostic value of plasma neurofilament light Nicholas J. Ashton Shorena Janelidze Ahmad Al Khleifat Antoine Leuzy Emma L. van der Ende Thomas K. Karikari Andrea L. Benedet Tharick A. Pascoal Alberto Lleó Lucilla Parnetti Daniela Galimberti Laura Bonanni Andrea Pilotto Alessandro Padovani Jan Lycke Lenka Novakova Markus Axelsson Latha Velayudhan Gil D. Rabinovici Bruce Miller Carmine Pariante Naghmeh Nikkheslat Susan M. Resnick Madhav Thambisetty Michael Schöll Gorka Fernández-Eulate Francisco J. Gil-Bea Adolfo López de Munain Ammar Al-Chalabi Pedro Rosa-Neto Andre Strydom Per Svenningsson Erik Stomrud Alexander Santillo Dag Aarsland John C. van Swieten Sebastian Palmqvist Henrik Zetterberg Kaj Blennow Abdul Hye Oskar Hansson Springer US Nature Communications, doi:10.1038/s41467-021-23620-z 10.1038/s41467-021-23620-z http://dx.doi.org/10.1038/s41467-021-23620-z journal Nature Communications © 2021, The Author(s) 2041-1723 10.1038/s41467-021-23620-z springer.com springerlink.com 2010-04-23 True 10.1038/s41467-021-23620-z springer.com springerlink.com Springer 2021-06-01T17:30:23+02:00 2021-05-29T17:00:21+05:30 2021-06-01T17:30:23+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:d19b9cd9-610f-4e74-b63b-26a78fa7ca8a uuid:13eae6cb-9cc0-4730-8c4c-a5f71fb0622b default 1 converted uuid:c12c5588-a50a-48d2-b8fc-2ab9e8427724 converted to PDF/A-2b pdfToolbox 2021-05-29T17:01:54+05:30 2 B Nicholas J. Ashton http://orcid.org/0000-0002-3579-8804 Ahmad Al Khleifat http://orcid.org/0000-0002-7406-9831 Thomas K. Karikari http://orcid.org/0000-0003-1422-4358 Alberto Lleó http://orcid.org/0000-0002-2568-5478 Daniela Galimberti http://orcid.org/0000-0002-9284-5953 Jan Lycke http://orcid.org/0000-0002-7891-8466 Latha Velayudhan http://orcid.org/0000-0002-7712-930X Carmine Pariante http://orcid.org/0000-0002-9132-5091 Michael Schöll http://orcid.org/0000-0001-7800-1781 Gorka Fernández-Eulate http://orcid.org/0000-0003-1112-7464 Ammar Al-Chalabi http://orcid.org/0000-0002-4924-7712 Sebastian Palmqvist http://orcid.org/0000-0002-9267-1930 Henrik Zetterberg http://orcid.org/0000-0003-3930-4354 Kaj Blennow http://orcid.org/0000-0002-1890-4193 Oskar Hansson http://orcid.org/0000-0001-8467-7286 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 473, 640, 475, 671 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 473, 643, 508, 674 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 640, 551, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 640, 551, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 129, 539, 130, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 129, 539, 130, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 539, 139, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 128, 539, 139, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 139, 539, 141, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 357, 539, 358, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 357, 539, 358, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 365, 539, 366, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 356, 539, 366, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 366, 539, 369, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 241, 523, 242, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 241, 523, 242, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 250, 523, 251, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 240, 523, 251, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 523, 253, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 523, 521, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 523, 521, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 529, 523, 530, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 519, 523, 530, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 530, 523, 532, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 210, 507, 211, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 210, 507, 211, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 219, 507, 220, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 209, 507, 220, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 220, 507, 222, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 87, 491, 88, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 87, 491, 88, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 96, 491, 97, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 491, 97, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 97, 491, 100, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 408, 491, 409, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 408, 491, 409, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 417, 491, 418, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 408, 491, 418, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 418, 491, 421, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 192, 475, 193, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 192, 475, 193, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 201, 475, 202, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 191, 475, 202, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 202, 475, 205, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 459, 111, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 459, 111, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 119, 459, 120, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 109, 459, 120, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 459, 122, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 259, 459, 260, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 259, 459, 260, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 268, 459, 269, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 258, 459, 269, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 269, 459, 272, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 293, 443, 294, 454 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 293, 443, 294, 454 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 302, 443, 303, 454 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 292, 443, 303, 454 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 443, 305, 454 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 412, 136, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 412, 136, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 143, 412, 144, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 134, 412, 144, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 144, 412, 147, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 412, 252, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 251, 412, 252, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 260, 412, 261, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 250, 412, 261, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 261, 412, 264, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 365, 412, 366, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 365, 412, 366, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 374, 412, 375, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 364, 412, 375, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 375, 412, 377, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 113, 396, 114, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 113, 396, 114, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 396, 123, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 112, 396, 123, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 123, 396, 126, 407 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 124, 652, 128, 660 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 95, 642, 99, 649 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 126, 558, 130, 566 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 225, 548, 228, 555 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 95, 537, 98, 545 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 144, 537, 147, 545 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 255, 537, 258, 545 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 269, 495, 273, 503 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 275, 495, 278, 503 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 273, 443, 280, 451 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 284, 443, 291, 451 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 76, 422, 83, 430 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 422, 94, 430 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 412, 94, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 412, 103, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 105, 412, 112, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 156, 412, 164, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 165, 412, 173, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 174, 412, 182, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 412, 190, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 126, 359, 133, 367 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 56, 286, 64, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 68, 286, 75, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 208, 286, 215, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 157, 276, 164, 283 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 217, 244, 224, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 244, 233, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 78, 213, 85, 221 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 213, 94, 221 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 197, 161, 204, 168 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 395, 646, 400, 655 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 420, 646, 425, 655 Flags: Print AppearanceDictionary: true Destination: 131 Annotation: Subtype: Link Rect: 385, 548, 389, 557 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 452, 516, 457, 526 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 323, 213, 327, 223 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 409, 192, 414, 202 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 409, 119, 414, 128 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 421, 53, 425, 62 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 446, 440, 450, 449 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 538, 440, 542, 449 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 454, 398, 458, 407 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 483, 377, 487, 386 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 483, 346, 488, 355 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 374, 314, 379, 324 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 369, 293, 373, 303 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 523, 105, 527, 114 Flags: Print AppearanceDictionary: true Destination: 170 Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 393, 461, 397, 470 Flags: Print AppearanceDictionary: true Destination: 170 Annotation: Subtype: Link Rect: 455, 419, 460, 428 Flags: Print AppearanceDictionary: true Destination: 170 Annotation: Subtype: Link Rect: 399, 346, 403, 355 Flags: Print AppearanceDictionary: true Destination: 170 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 268, 155, 275, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 466, 144, 473, 152 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 330, 56, 337, 64 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 339, 56, 346, 64 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 61, 715, 68, 723 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 70, 715, 77, 723 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 79, 715, 86, 723 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 160, 684, 167, 691 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 527, 187, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 229, 516, 236, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 240, 516, 247, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 77, 265, 85, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 265, 93, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 95, 265, 102, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 141, 265, 149, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 150, 265, 158, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 207, 265, 214, 273 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 157, 244, 164, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 166, 244, 173, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 175, 244, 182, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 184, 244, 191, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 193, 244, 200, 252 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 136, 234, 143, 241 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 145, 234, 152, 241 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 366, 618, 370, 627 Flags: Print AppearanceDictionary: true Destination: 170 Annotation: Subtype: Link Rect: 350, 610, 357, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 358, 610, 365, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 366, 555, 370, 564 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 345, 516, 352, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 353, 516, 360, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 362, 516, 369, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 370, 516, 377, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 379, 516, 386, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 516, 395, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 396, 516, 403, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 417, 475, 424, 482 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 425, 475, 432, 482 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 475, 443, 482 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 91, 401, 94, 407 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 95, 401, 101, 407 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 104, 401, 110, 407 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 223, 316, 229, 322 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 230, 316, 236, 322 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 80, 299, 85, 305 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 79, 291, 85, 297 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 155, 240, 160, 246 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 242, 181, 248, 187 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 78, 122, 84, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 122, 91, 128 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 93, 122, 98, 128 Flags: Print AppearanceDictionary: true Destination: 311 Annotation: Subtype: Link Rect: 100, 122, 105, 128 Flags: Print AppearanceDictionary: true Destination: 346 Annotation: Subtype: Link Rect: 107, 122, 112, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 114, 122, 119, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 121, 122, 126, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 539, 595, 544, 601 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 492, 515, 498, 521 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 447, 413, 453, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 473, 345, 478, 351 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 480, 345, 485, 351 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 270, 397, 291, 405 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 58, 388, 173, 396 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 58, 336, 178, 344 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 103, 258, 223, 265 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 210, 240, 281, 248 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 58, 232, 119, 239 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 618, 454, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 445, 418, 534, 425 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 409, 343, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 357, 549, 364 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 348, 341, 355 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 481, 226, 551, 233 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 217, 362, 225 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 246, 714, 291, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 58, 705, 144, 713 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 66, 338, 103, 345 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 337, 311, 459, 318 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 251, 546, 258 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 114, 551, 121 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 105, 346, 112 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 444, 413, 519, 421 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 523, 413, 543, 421 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 403, 108, 411 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: c1826d9a Type: CRC32 Checksum: 538c9e191e156acb2dfc0a3277837a87 Type: MD5 Checksum: 781ea26c84cc13d0fd6fad3dc365f86918071420 Type: SHA-1