d6fce9c7b3589c77f192a7d04fc6cae5 271965.pdf 19973e91fed2c913098e87fa0ffb49f1029145b0 271965.pdf a7f5db8a701bfe37829e26b89ca38e9ce0eba7fe757b0082760d7aeb83d00c1e 271965.pdf Title: Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association Subject: Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7–23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients’ survival. In fact, while the 52-week survival of the overall population was 71.4 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease.18pt Keywords: interstitial pneumonia; idiopathic pulmonary fibrosis; vasculitis; rheumatic diseases; anti-myeloperoxidase antibodies Author: Marco Sebastiani, Fabrizio Luppi, Gianluca Sambataro, Diego Castillo Villegas, Stefania Cerri, Paola Tomietto, Giulia Cassone, Marialuisa Bocchino, Belen Atienza-Mateo, Paolo Cameli, Patricia Moya Alvarado, Paola Faverio, Elena Bargagli, Carlo Vancheri, Miguel A. Gonzalez-Gay, Enrico Clini, Carlo Salvarani and Andreina Manfredi Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jun 9 11:03:29 2021 CEST ModDate: Wed Jun 9 11:15:41 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 959592 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OTOCOX+VnURWPalladioL Type 1 Custom yes yes no 10 0 ZOWTDD+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 ZTUWJI+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 FPZPMO+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 LGTZLE+CMSY10 Type 1 Builtin yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 84 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 99 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 103 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 107 0 ABCDEE+宋体 TrueType WinAnsi yes yes no 111 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 121 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 125 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 129 0 ABCDEE+宋体 TrueType WinAnsi yes yes no 133 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:02:38 CEST RepresentationInformation: 271965.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:14 CEST Size: 959592 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 271 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Population and Data Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Info: Title: Interstitial Lung Disease and Anti-Myeloperoxidase Antibodies: Not a Simple Association Author: Marco Sebastiani, Fabrizio Luppi, Gianluca Sambataro, Diego Castillo Villegas, Stefania Cerri, Paola Tomietto, Giulia Cassone, Marialuisa Bocchino, Belen Atienza-Mateo, Paolo Cameli, Patricia Moya Alvarado, Paola Faverio, Elena Bargagli, Carlo Vancheri, Miguel A. Gonzalez-Gay, Enrico Clini, Carlo Salvarani and Andreina Manfredi Subject: Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7 23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients’ survival. In fact, while the 52-week survival of the overall population was 71.4 7.5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37.7 and 41.5% of cases, respectively, while disease progression at chest HRCT was observed in 45.2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease.18pt Keywords: interstitial pneumonia; idiopathic pulmonary fibrosis; vasculitis; rheumatic diseases; anti-myeloperoxidase antibodies Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jun 09 11:03:29 CEST 2021 ModDate: Wed Jun 09 11:15:41 CEST 2021 ID: 0xefd9922bb31a727da4c5863df64169c1, 0xefd9922bb31a727da4c5863df64169c1 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ZTUWJI+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: ZTUWJI+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: URYLRZ+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: URYLRZ+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, 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