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Prior-Español Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu May 20 21:02:01 2021 CEST ModDate: Fri May 21 05:37:26 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 922695 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LFATAM+Wingdings-Regular Type 1C WinAnsi yes yes yes 309 0 MinionPro-Regular Type 1C Custom yes no yes 34 0 GMTKWR+Corbel-Bold CID TrueType Identity-H yes yes yes 35 0 Corbel2 TrueType WinAnsi yes no yes 36 0 YXYYOH+Corbel CID TrueType Identity-H yes yes yes 37 0 MinionPro-It Type 1C Custom yes no yes 52 0 MinionPro-Bold Type 1C Custom yes no yes 53 0 Corbel2 TrueType WinAnsi yes no yes 57 0 RMIJPV+ArialMT Type 1C WinAnsi yes yes no 67 0 RMIJPV+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 79 0 RMIJPV+ArialMT Type 1C WinAnsi yes yes no 80 0 TimesNewRomanPSMT2 TrueType WinAnsi yes no yes 172 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-24 02:30:57 CEST RepresentationInformation: 271980.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-23 15:31:26 CEST Size: 922695 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 377 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Clinical factors associated with discontinuation of tsbDMARDs in rheumatic patients from the BIOBADASER III registry Children: Item: Title: Patients and methods Children: Item: Title: Study design and setting: BIOBADASER 3.0. Item: Title: Population. Item: Title: Outcome variables. Item: Title: Statistical analysis. Item: Title: Results Children: Item: Title: Kaplan–Meier survival analysis. Item: Title: Factors associated with treatment discontinuations in RA. Item: Title: Factors associated with treatment discontinuation in PsA. Item: Title: Factors associated with treatment discontinuation in AS. Item: Title: Discussion Item: Title: Conclusion Item: Title: Ethics approval Item: Title: Consent to participate Item: Title: Consent for publication Item: Title: References Item: Title: Acknowledgements Info: Title: Clinical factors associated with discontinuation of ts/bDMARDs in rheumatic patients from the BIOBADASER III registry Author: A. Prior-Español Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-90442-w Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu May 20 21:32:01 CEST 2021 ModDate: Fri May 21 05:37:26 CEST 2021 ID: 0x8969513ef274b4a866af7eafd8f73899, 0xb6da97260cb84daf8661cee90ceaa44d Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: GMTKWR+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: YXYYOH+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: RMIJPV+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RMIJPV+ArialMT Flags: Nonsymbolic FontBBox: -222, -325, 1072, 1037 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RMIJPV+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RMIJPV+ArialMT Flags: Nonsymbolic FontBBox: -222, -325, 1072, 1037 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LFATAM+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: LFATAM+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RMIJPV+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 99 FontDescriptor: FontName: RMIJPV+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: Corbel2 FirstChar: 32 LastChar: 124 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TimesNewRomanPSMT2 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: TimesNewRomanPSMT2 Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: YXYYOH+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YXYYOH+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: GMTKWR+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GMTKWR+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2021-05-21T00:32:01+05:30 Springer 2021-05-21T05:37:26+02:00 2021-05-21T05:37:26+02:00 application/pdf https://doi.org/10.1038/s41598-021-90442-w Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-90442-w Clinical factors associated with discontinuation of ts/bDMARDs in rheumatic patients from the BIOBADASER III registry A. Prior-Español C. Sánchez-Piedra J. Campos F. J. Manero C. Pérez-García C. Bohórquez N. Busquets-Pérez J. M. Blanco-Madrigal C. Díaz-Torne F. Sánchez-Alonso L. Mateo S. 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