e9a916c75df362e90ffb7fe8609d9b53 272000.pdf d79fcb33fbc8b8aa78d6fb123206404d68798270 272000.pdf 34332c6b9edd6a201dc6ceec55ecc5aa4e80e0fe42d45c43803b204cbe9f7b2d 272000.pdf Title: Pexidartinib long-term hepatic safety profile in TGCT patients Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Fri Apr 23 13:33:20 2021 CEST ModDate: Wed Mar 8 10:40:43 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 583.937 x 782.362 pts Page rot: 0 File size: 921859 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DKMONC+AdvTT26e64a0d.BI Type 1C WinAnsi yes yes no 52 0 DKMONB+AdvTT0eeac7f7.B Type 1C WinAnsi yes yes no 30 0 DKMONA+AdvTT7b515deb+20 Type 1C WinAnsi yes yes no 31 0 DKMOMP+AdvTT06f3545d.I+fb Type 1C Custom yes yes yes 202 0 DKMOMO+AdvTT06f3545d.I Type 1C WinAnsi yes yes no 37 0 DKMOLN+AdvTT7b515deb+fb Type 1C Custom yes yes yes 32 0 DKMOLM+AdvTT7b515deb Type 1C WinAnsi yes yes no 35 0 DKMOFN+AdvTT2ffda40f.B+fb Type 1C Custom yes yes yes 98 0 DKMOEN+AdvTT2ffda40f.B Type 1C WinAnsi yes yes no 36 0 EHTKCP+ArialMT TrueType WinAnsi yes yes no 1 0 DKMPHA+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 33 0 DKMPGP+AdvTT7b515deb+22 Type 1C Custom yes yes yes 34 0 DKNAEM+AdvTT2ffda40f.B+22 Type 1C Custom yes yes yes 59 0 DKNAIN+HelveticaLTStd-Obl Type 1C WinAnsi yes yes no 68 0 DKNAIM+HelveticaLTStd-Bold Type 1C WinAnsi yes yes no 69 0 DKNAHM+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 70 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-09 02:37:07 CET RepresentationInformation: 272000.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-08 10:55:41 CET Size: 921859 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 242 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Pexidartinib Long-Term Hepatic Safety Profile in Patients with Tenosynovial Giant Cell Tumors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Study Design and Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Assessments and Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Patient Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Characterization of Liver Test Abnormalities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Mixed or Cholestatic Hepatotoxicity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Serious Hepatic Adverse Reactions in Patients Without TGCTs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Recommended Dose Modifications and the Pexidartinib Risk Evaluation and Mitigation Strategy Program Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Disclosures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Info: Title: Pexidartinib long-term hepatic safety profile in TGCT patients Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Fri Apr 23 14:03:20 CEST 2021 ModDate: Wed Mar 08 10:40:43 CET 2023 ID: 0xa7c747f552921dbdb7bb621bd8263a2b, 0xb9966632f259cdeb3a5fd03b2410307b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 769 ImageHeight: 581 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 769 ImageHeight: 581 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 73 ImageHeight: 102 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: DKMOLN+AdvTT7b515deb+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKMOLN+AdvTT7b515deb+fb Flags: Symbolic FontBBox: 0, -187, 739, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMPHA+AdvOT8608a8d1 FontSubset: true FirstChar: 215 LastChar: 215 FontDescriptor: FontName: DKMPHA+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMOFN+AdvTT2ffda40f.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKMOFN+AdvTT2ffda40f.B+fb Flags: Symbolic FontBBox: 0, -187, 781, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMPGP+AdvTT7b515deb+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKMPGP+AdvTT7b515deb+22 Flags: Symbolic FontBBox: -83, -187, 791, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMOLM+AdvTT7b515deb FontSubset: true FirstChar: 37 LastChar: 246 FontDescriptor: FontName: DKMOLM+AdvTT7b515deb Flags: Serif, Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMOEN+AdvTT2ffda40f.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: DKMOEN+AdvTT2ffda40f.B Flags: Serif, Nonsymbolic FontBBox: -83, -187, 875, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKNAIN+HelveticaLTStd-Obl FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: DKNAIN+HelveticaLTStd-Obl Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMOMO+AdvTT06f3545d.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: DKMOMO+AdvTT06f3545d.I Flags: Serif, Nonsymbolic FontBBox: -104, -187, 937, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKNAIM+HelveticaLTStd-Bold FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: DKNAIM+HelveticaLTStd-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKNAHM+HelveticaLTStd-Roman FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: DKNAHM+HelveticaLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMOMP+AdvTT06f3545d.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKMOMP+AdvTT06f3545d.I+fb Flags: Symbolic FontBBox: -104, -187, 812, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMONC+AdvTT26e64a0d.BI FontSubset: true FirstChar: 44 LastChar: 117 FontDescriptor: FontName: DKMONC+AdvTT26e64a0d.BI Flags: Serif, Nonsymbolic FontBBox: -93, -187, 958, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKNAEM+AdvTT2ffda40f.B+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKNAEM+AdvTT2ffda40f.B+22 Flags: Symbolic FontBBox: -83, -187, 791, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKMONB+AdvTT0eeac7f7.B FontSubset: true FirstChar: 65 LastChar: 87 FontDescriptor: FontName: DKMONB+AdvTT0eeac7f7.B Flags: Nonsymbolic FontBBox: 0, -218, 958, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKMONA+AdvTT7b515deb+20 FontSubset: true FirstChar: 129 LastChar: 151 FontDescriptor: FontName: DKMONA+AdvTT7b515deb+20 Flags: Nonsymbolic FontBBox: -208, -229, 1041, 854 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: EHTKCP+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: EHTKCP+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding XMP: VoR 10.1002/onco.13629 10.1002/onco.13629 10.1002/(ISSN)1549-490X 3 Pexidartinib long-term hepatic safety profile in TGCT patients Acrobat Distiller 11.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT2023-03-08T09:40:43+00:00 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 92, 625, 101, 633 Annotation: Subtype: Link Rect: 174, 625, 182, 633 Annotation: Subtype: Link Rect: 435, 90, 532, 98 Annotation: Subtype: Link Rect: 51, 80, 65, 89 Annotation: Subtype: Link Rect: 485, 80, 532, 89 Annotation: Subtype: Link Rect: 51, 71, 137, 79 Annotation: Subtype: Link Rect: 238, 61, 435, 70 Thumb: true Page: Label: 2 Thumb: true Page: Label: 3 Thumb: true Page: Label: 4 Thumb: true Page: Label: 5 Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Thumb: true Page: Label: 8 Thumb: true Page: Label: 9 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 220, 187, 283, 197 Annotation: Subtype: Link Rect: 100, 129, 268, 139 Annotation: Subtype: Link Rect: 112, 61, 283, 70 Annotation: Subtype: Link Rect: 51, 49, 209, 59 Thumb: true Page: Label: 11 Thumb: true Checksum: 0fb25c60 Type: CRC32 Checksum: e9a916c75df362e90ffb7fe8609d9b53 Type: MD5 Checksum: d79fcb33fbc8b8aa78d6fb123206404d68798270 Type: SHA-1