faac649bc43b43f1280129dfd0413f32 272004.pdf 78917420a5c90fadd09629afa2ee9e1653421af5 272004.pdf 4396308725ed6a7de4e7e18edc190253e3fc3e91b403ba693d7afccf2c931e69 272004.pdf Title: Ischemic Etiology and Prognosis in Men and Women with Acute Heart Failure Subject: Coronary heart disease is common in heart failure (HF). Our aim was to determine the impact of ischemic etiology on prognosis among men and women with HF. This study is a prospective national multicenter registry. The primary endpoint was 12-month mortality. Patients with HF and ischemic heart disease were stratified according to sex. A total of 1830 patients were enrolled of which 756 (41.3%) were women. Ischemic etiology was more common in men (446 (41.6%)) than in women (167 (22.2%)). Among patients with ischemic HF, diabetes was more frequent in women than in men. Ischemic etiology was not associated with higher mortality risk, and this was true for women (Hazard Ratio [HR] 1.51, 95% Confidence Interval [CI] 0.98–2.32; p = 0.61) and men (HR 1.14, 95% CI 0.81–1.61; p = 0.46), p-value for interaction: 0.067. Mortality/readmission risk in ischemic HF increased in men with previous readmissions (HR 1.15, 95% CI 1.02–1.29; p = 0.022), chronic obstructive pulmonary disease (HR1.20, 95% CI 1.02–1.41; p = 0.026) and in women with diabetes (HR 2.23, 95% CI 1.05–4.47; p = 0.035). Ischemic etiology was not associated with mortality in HF patients. In ischemic HF, the variables associated with a poor prognosis were diabetes in women and previous readmissions and chronic obstructive pulmonary disease in men. Keywords: heart failure; mortality; ischemic heart disease Author: Lourdes Vicent, Jose Guerra, Rafael Vazquez-García, José R. Gonzalez-Juanatey, Luis Martínez Dolz, Javier Segovia, Domingo Pascual-Figal, Ramón Bover, Fernando Worner, Juan Delgado, Francisco Fernández-Avilés and Manuel Martínez-Sellés Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Apr 21 05:11:51 2021 CEST ModDate: Wed Apr 21 06:17:58 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 919710 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XAWNGI+VnURWPalladioL Type 1 Custom yes yes no 10 0 BXIMBC+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 JTBOJD+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 MAWRYG+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 LGTZLE+CMSY10 Type 1 Builtin yes yes no 81 0 JLZORU+EURM10 Type 1 Builtin yes yes no 85 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 92 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:01:53 CEST RepresentationInformation: 272004.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:16 CEST Size: 919710 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 267 FreeObjects: 3 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Comorbidities and Cardiovascular Risk Factors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Heart Failure Therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Mortality and Hospital Readmissions during Follow-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Info: Title: Ischemic Etiology and Prognosis in Men and Women with Acute Heart Failure Author: Lourdes Vicent, Jose Guerra, Rafael Vazquez-García, José R. Gonzalez-Juanatey, Luis Martínez Dolz, Javier Segovia, Domingo Pascual-Figal, Ramón Bover, Fernando Worner, Juan Delgado, Francisco Fernández-Avilés and Manuel Martínez-Sellés Subject: Coronary heart disease is common in heart failure (HF). Our aim was to determine the impact of ischemic etiology on prognosis among men and women with HF. This study is a prospective national multicenter registry. The primary endpoint was 12-month mortality. Patients with HF and ischemic heart disease were stratified according to sex. A total of 1830 patients were enrolled of which 756 (41.3%) were women. Ischemic etiology was more common in men (446 (41.6%)) than in women (167 (22.2%)). Among patients with ischemic HF, diabetes was more frequent in women than in men. Ischemic etiology was not associated with higher mortality risk, and this was true for women (Hazard Ratio [HR] 1.51, 95% Confidence Interval [CI] 0.98 2.32; p = 0.61) and men (HR 1.14, 95% CI 0.81 1.61; p = 0.46), p-value for interaction: 0.067. Mortality/readmission risk in ischemic HF increased in men with previous readmissions (HR 1.15, 95% CI 1.02 1.29; p = 0.022), chronic obstructive pulmonary disease (HR1.20, 95% CI 1.02 1.41; p = 0.026) and in women with diabetes (HR 2.23, 95% CI 1.05 4.47; p = 0.035). Ischemic etiology was not associated with mortality in HF patients. In ischemic HF, the variables associated with a poor prognosis were diabetes in women and previous readmissions and chronic obstructive pulmonary disease in men. 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