9d2a9911bde2016ab9b4e83f14713072 272009.pdf f13f88dc712e96fe0fc412cf2f2211303c8e29bd 272009.pdf 12f3dd0922c115a2b5e41ae5b0e8c5defc146c0a195822b1e5ac4f1a44b53e3a 272009.pdf Title: Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study Subject: Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis. Keywords: NMR analysis of lipoproteins; lipid profile; premature cardiovascular disease; residual cardiovascular risk; small dense LDL; lipoprotein particle number; lipoprotein precipitation Author: Bárbara Fernández-Cidón, Beatriz Candás-Estébanez, Miriam Gil-Serret, Núria Amigó, Emili Corbella, M. Ángeles Rodríguez-Sánchez, Ariadna Padró-Miquel, Carlos Brotons, Antonio Hernández-Mijares, Pilar Calmarza, Estibaliz Jarauta, Angel J. Brea, Marta Mauri, Carlos Guijarro, Àlex Vila, Pedro Valdivielso, Xavier Corbella and Xavier Pintó Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Mar 30 08:20:49 2021 CEST ModDate: Fri Apr 9 05:13:10 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 470123 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DJVUWO+VnURWPalladioL Type 1 Custom yes yes no 10 0 SLRLJF+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 QNXGHB+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 BCRCCU+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 UTMIUZ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 OHXQCJ+CMSY10 Type 1 Builtin yes yes no 84 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 88 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 95 0 BFNFDF+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 110 0 BFNJGE+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 116 0 BFNFFF+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 119 0 BFNFFG+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 125 0 BFNFGH+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 131 0 BFNFGI+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 134 0 BFNFHI+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 137 0 BFNJGD+PalatinoLinotype-BoldItalic CID TrueType Identity-H yes yes yes 140 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:01:40 CEST RepresentationInformation: 272009.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:16 CEST Size: 470123 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 297 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Variables Included Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Sample Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Lipoprotein Precipitation Techniques Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Nuclear Magnetic Resonance (NMR) Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Info: Title: Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study Author: Bárbara Fernández-Cidón, Beatriz Candás-Estébanez, Miriam Gil-Serret, Núria Amigó, Emili Corbella, M. Ángeles Rodríguez-Sánchez, Ariadna Padró-Miquel, Carlos Brotons, Antonio Hernández-Mijares, Pilar Calmarza, Estibaliz Jarauta, Angel J. Brea, Marta Mauri, Carlos Guijarro, Àlex Vila, Pedro Valdivielso, Xavier Corbella and Xavier Pintó Subject: Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis. 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