9ca818ce0f853e95957a02d2111f37cf 272088.pdf ac7c90878f5c33c997ec9f0ce76eb55c25462644 272088.pdf 67926706864d52ef2f1d672b5ef80778b5ce249d128188dae466d0aa209c14af 272088.pdf Title: Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease Subject: Neuromuscular Disorders, 31 (2021) 265-280. doi:10.1016/j.nmd.2021.01.009 Keywords: "[16] Clinical neurology examination"; "[21] Clinical trials methodology"; "[54] Cohort study"; "[176] All neuromuscular disease"; "[185] Muscle disease" Author: Ursula Moore Creator: Elsevier Producer: Acrobat Distiller 10.1.10 (Windows) CreationDate: Tue Mar 30 20:50:30 2021 CEST ModDate: Tue Mar 30 20:51:08 2021 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.245 x 793.92 pts Page rot: 0 File size: 4776631 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GFOGFC+Times-Bold Type 1C WinAnsi yes yes no 534 0 GFOGCB+MTSY Type 1C Custom yes yes yes 537 0 GFOGCC+Times-Italic Type 1C WinAnsi yes yes no 542 0 GFOFOA+UniversLTStd Type 1C Custom yes yes yes 545 0 GFOFOC+Times-Roman Type 1C Custom yes yes no 550 0 GFOFOB+dummy-space Type 1C WinAnsi yes yes no 554 0 GGADHE+RMTMI Type 1C Custom yes yes yes 245 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-14 02:37:17 CET RepresentationInformation: 272088.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-13 18:01:48 CET Size: 4776631 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn1' cannot be found Offset: 4748840 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn2' cannot be found Offset: 4748840 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 635 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2 Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 2.1 NSAD score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.2 MMT score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.3 Mercuri score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.4 Distal to proximal involvement ratio Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.5 Principle component analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.6 Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: 3.1 Demographics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 3.2 Genetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 3.3 NSAD sequence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 3.4 MMT sequence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3.5 MRI sequence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 3.6 Site to site variation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3.7 Principal component analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Study funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Study sponsorship and author disclosures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Appendix 1. Authors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Appendix 2 Coinvestigators - The Jain COS Consortium Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease Author: Ursula Moore Subject: Neuromuscular Disorders, 31 (2021) 265-280. doi:10.1016/j.nmd.2021.01.009 Keywords: "[16] Clinical neurology examination"; "[21] Clinical trials methodology"; "[54] Cohort study"; "[176] All neuromuscular disease"; "[185] Muscle disease" Creator: Elsevier Producer: Acrobat Distiller 10.1.10 (Windows) CreationDate: Tue Mar 30 21:20:30 CEST 2021 ModDate: Tue Mar 30 21:21:08 CEST 2021 ID: 0xf1771df2d2bc597759656486ef2ef9b7, 0x17ad11282bf1d81d0f0c3e8b33d87cc0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 402 ImageHeight: 55 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 148 ImageHeight: 148 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 203 ImageHeight: 247 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 228 ImageHeight: 249 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1208 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1500 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1450 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 1984 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1805 ImageHeight: 1069 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1305 ImageHeight: 1555 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1905 ImageHeight: 1176 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GFOFOA+UniversLTStd FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: GFOFOA+UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGADHE+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: GGADHE+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GFOGFC+Times-Bold FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: GFOGFC+Times-Bold Flags: Serif, Nonsymbolic, ForceBold FontBBox: -168, -218, 1000, 935 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GFOFOC+Times-Roman FontSubset: true FirstChar: 30 LastChar: 243 FontDescriptor: FontName: GFOFOC+Times-Roman Flags: Serif, Nonsymbolic FontBBox: -168, -218, 1000, 898 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GFOGCB+MTSY FontSubset: true FirstChar: 2 LastChar: 138 FontDescriptor: FontName: GFOGCB+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GFOFOB+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: GFOFOB+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GFOGCC+Times-Italic FontSubset: true FirstChar: 38 LastChar: 252 FontDescriptor: FontName: GFOGCC+Times-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -169, -217, 1010, 883 FontFile3: true Encoding: WinAnsiEncoding XMP: 2021-03-31T00:20:30+05:30 Elsevier 2021-03-31T00:21:08+05:30 2021-03-31T00:21:08+05:30 Acrobat Distiller 10.1.10 (Windows) [16] Clinical neurology examination,[21] Clinical trials methodology,[54] Cohort study,[176] All neuromuscular disease,[185] Muscle disease application/pdf doi:10.1016/j.nmd.2021.01.009 Elsevier B.V. Neuromuscular Disorders, 31 (2021) 265-280. doi:10.1016/j.nmd.2021.01.009 [16] Clinical neurology examination [21] Clinical trials methodology [54] Cohort study [176] All neuromuscular disease [185] Muscle disease Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease Ursula Moore Heather Gordish Jordi Diaz-Manera Meredith K. James Anna G. Mayhew Michela Guglieri Roberto Fernandez-Torron Laura E. Rufibach Jia Feng Andrew M. Blamire Pierre G. Carlier Simone Spuler John W. Day Kristi J. Jones Diana X. Bharucha-Goebel Emmanuelle Salort-Campana Alan Pestronk Maggie C. Walter Carmen Paradas Tanya Stojkovic Madoka Mori-Yoshimura Elena Bravver Elena Pegoraro Linda Pax Lowes Jerry R. Mendell Kate Bushby Volker Straub Jain COS Consortium uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:cac43bf8-eab1-49f0-b790-2a7b89ce3602 journal © 2021 The Authors. Published by Elsevier B.V. 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