c190bd08d747615ce52c1f89543e7a7a  272119.pdf
27b8aa56322b47b0ea063c9ce95d18ffe25b8b43  272119.pdf
902b40f8a9ef7361f59f66f159b459e033e07754e2ae5e7e06850e62a464266e  272119.pdf

Title:          A randomised, placebo-controlled phase 3 study to evaluate the efficacy and safety of ASP0113, a DNA-based CMV vaccine, in seropositive allogeneic haematopoietic cell transplant recipients
Subject:        EClinicalMedicine, 33 (2021) 100787. doi:10.1016/j.eclinm.2021.100787
Author:         Per Ljungman
Creator:        Elsevier
Producer:       Acrobat Distiller 10.1.10 (Windows)
CreationDate:   Thu Mar 25 14:09:11 2021 CET
ModDate:        Thu Mar 25 14:09:36 2021 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      1284201 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GPFLPC+AdvP4C9543                    Type 1C           Custom           yes yes yes    311  0
GPFLPA+AdvOTf2586c63+fb              Type 1C           Custom           yes yes yes    316  0
GPFLOO+AdvOTf2586c63                 Type 1C           WinAnsi          yes yes no     321  0
GPFLOP+AdvP4C4E59                    Type 1C           Custom           yes yes yes    324  0
GPFLOL+AdvOT5fa4e291                 Type 1C           WinAnsi          yes yes no     329  0
GPFLON+AdvP4C4E74                    Type 1C           Custom           yes yes yes    332  0
GPFLPB+AdvOTf2586c63+20              Type 1C           WinAnsi          yes yes no     337  0
GPGCPF+AdvPAC3D                      Type 1C           WinAnsi          yes yes no     340  0
GPFLOM+AdvOT5fa4e291+fb              Type 1C           Custom           yes yes yes    343  0
GPGDIE+AdvP4C9542                    Type 1C           WinAnsi          yes yes no     167  0
GPGDID+AdvTTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     170  0
GPGDJE+AdvP4A5FDB                    Type 1C           WinAnsi          yes yes no      25  0
GPGDJG+AdvP697C                      Type 1C           Custom           yes yes no     173  0
GPGDJF+AdvOT5fa4e291+20              Type 1C           WinAnsi          yes yes no     177  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-27 02:59:49 CEST
 RepresentationInformation: 272119.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-31 12:05:22 CEST
  Size: 1284201
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 432
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: A randomised, placebo-controlled phase 3 study to evaluate the efficacy and safety of ASP0113, a DNA-based CMV vaccine, in seropositive allogeneic haematopoietic cell transplant recipients
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
       Item: 
        Title: 2. Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
        Children: 
         Item: 
          Title: 2.1. Study design and participants
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
         Item: 
          Title: 2.2. Randomisation and masking
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
         Item: 
          Title: 2.3. Procedures
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
         Item: 
          Title: 2.4. Outcomes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
         Item: 
          Title: 2.5. Statistical analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
         Item: 
          Title: 2.6. Role of the funding source
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
       Item: 
        Title: 5. Contributors
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: Data sharing
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
       Item: 
        Title: Funding
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: Supplementary materials
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
        Children: 
         Item: 
          Title: References
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
   Info: 
    Title: A randomised, placebo-controlled phase 3 study to evaluate the efficacy and safety of ASP0113, a DNA-based CMV vaccine, in seropositive allogeneic haematopoietic cell transplant recipients
    Author: Per Ljungman
    Subject: EClinicalMedicine, 33 (2021) 100787. doi:10.1016/j.eclinm.2021.100787
    Creator: Elsevier
    Producer: Acrobat Distiller 10.1.10 (Windows)
    CreationDate: Thu Mar 25 14:39:11 CET 2021
    ModDate: Thu Mar 25 14:39:36 CET 2021
   ID: 0xc4a4296ecf34af692d50336f7ab24c72, 0x55f20ede28911df4e3b695491dc0b0fe
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 224
      ImageHeight: 299
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1100
      ImageHeight: 1368
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1800
      ImageHeight: 1232
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1795
      ImageHeight: 1209
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: GPFLOO+AdvOTf2586c63
      FontSubset: true
      FirstChar: 38
      LastChar: 237
      FontDescriptor: 
       FontName: GPFLOO+AdvOTf2586c63
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPFLOP+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 160
      FontDescriptor: 
       FontName: GPFLOP+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPGDIE+AdvP4C9542
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: GPGDIE+AdvP4C9542
       Flags: Nonsymbolic
       FontBBox: 0, -208, 979, 677
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPFLOL+AdvOT5fa4e291
      FontSubset: true
      FirstChar: 37
      LastChar: 169
      FontDescriptor: 
       FontName: GPFLOL+AdvOT5fa4e291
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPGDID+AdvTTb83ee1dd.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: GPGDID+AdvTTb83ee1dd.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPFLON+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 122
      FontDescriptor: 
       FontName: GPFLON+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPGDJG+AdvP697C
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GPGDJG+AdvP697C
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: GPFLPB+AdvOTf2586c63+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: GPFLPB+AdvOTf2586c63+20
       Flags: Nonsymbolic
       FontBBox: -41, -208, 885, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPGDJF+AdvOT5fa4e291+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: GPGDJF+AdvOT5fa4e291+20
       Flags: Nonsymbolic
       FontBBox: 19, -208, 947, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPGCPF+AdvPAC3D
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: GPGCPF+AdvPAC3D
       Flags: Nonsymbolic
       FontBBox: -166, -239, 989, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPFLPC+AdvP4C9543
      FontSubset: true
      FirstChar: 1
      LastChar: 167
      FontDescriptor: 
       FontName: GPFLPC+AdvP4C9543
       Flags: Symbolic
       FontBBox: 0, -947, 1041, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPFLOM+AdvOT5fa4e291+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: GPFLOM+AdvOT5fa4e291+fb
       Flags: Symbolic
       FontBBox: 40, 0, 572, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPGDJE+AdvP4A5FDB
      FontSubset: true
      FirstChar: 98
      LastChar: 103
      FontDescriptor: 
       FontName: GPGDJE+AdvP4A5FDB
       Flags: Nonsymbolic
       FontBBox: 0, -239, 979, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPFLPA+AdvOTf2586c63+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GPFLPA+AdvOTf2586c63+fb
       Flags: Symbolic
       FontBBox: -114, -208, 833, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2021-03-25T18:39:11+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2021-03-25T18:39:36+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2021-03-25T18:39:36+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.1.10 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.eclinm.2021.100787</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Ltd</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag/>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">EClinicalMedicine, 33 (2021) 100787. doi:10.1016/j.eclinm.2021.100787</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">A randomised, placebo-controlled phase 3 study to evaluate the efficacy and safety of ASP0113, a DNA-based CMV vaccine, in seropositive allogeneic haematopoietic cell transplant recipients</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Per Ljungman</rdf:li>
               <rdf:li>Arancha Bermudez</rdf:li>
               <rdf:li>Aaron C. Logan</rdf:li>
               <rdf:li>Mohamed A. Kharfan-Dabaja</rdf:li>
               <rdf:li>Patrice Chevallier</rdf:li>
               <rdf:li>Rodrigo Martino</rdf:li>
               <rdf:li>Gerald Wulf</rdf:li>
               <rdf:li>Dominik Selleslag</rdf:li>
               <rdf:li>Kazuhiko Kakihana</rdf:li>
               <rdf:li>Amelia Langston</rdf:li>
               <rdf:li>Dong-Gun Lee</rdf:li>
               <rdf:li>Carlos Solano</rdf:li>
               <rdf:li>Shinichiro Okamoto</rdf:li>
               <rdf:li>Larry R. Smith</rdf:li>
               <rdf:li>Michael Boeckh</rdf:li>
               <rdf:li>John R. Wingard</rdf:li>
               <rdf:li>Beth Cywin</rdf:li>
               <rdf:li>Christine Fredericks</rdf:li>
               <rdf:li>Christopher Lademacher</rdf:li>
               <rdf:li>Xuegong Wang</rdf:li>
               <rdf:li>James Young</rdf:li>
               <rdf:li>Johan Maertens</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:41c6a363-e26e-4e45-9831-62dec68fd38e</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:copyright>© 2021 The Authors. Published by Elsevier Ltd.</prism:copyright>
         <prism:publicationName>EClinicalMedicine</prism:publicationName>
         <prism:issn>2589-5370</prism:issn>
         <prism:volume>33</prism:volume>
         <prism:doi>10.1016/j.eclinm.2021.100787</prism:doi>
         <prism:url>https://doi.org/10.1016/j.eclinm.2021.100787</prism:url>
         <prism:startingPage>100787</prism:startingPage>
         <prism:pageRange>100787</prism:pageRange>
         <prism:coverDisplayDate>March 2021</prism:coverDisplayDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.eclinm.2021.100787</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:AuthoritativeDomain>
            <rdf:Bag>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Bag>
         </pdfx:AuthoritativeDomain>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 108, 559, 112, 570
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 114, 554, 119, 565
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 215, 559, 219, 570
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 296, 559, 299, 570
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 443, 559, 448, 570
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 449, 560, 453, 567
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 126, 546, 130, 557
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 214, 546, 216, 557
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 280, 546, 284, 557
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 374, 546, 379, 557
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 476, 546, 478, 557
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 122, 533, 124, 544
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 198, 533, 202, 544
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 271, 533, 274, 544
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 374, 533, 381, 544
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 454, 533, 459, 544
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 460, 535, 464, 541
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 118, 520, 122, 531
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 205, 520, 210, 531
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 270, 520, 274, 531
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 375, 520, 379, 531
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 160, 507, 165, 518
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 243, 507, 248, 518
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 314, 507, 319, 518
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 399, 507, 402, 518
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 99, 108, 155, 115
      Annotation: 
       Subtype: Link
       Rect: 42, 66, 174, 72
      Annotation: 
       Subtype: Link
       Rect: 368, 57, 497, 63
      Annotation: 
       Subtype: Link
       Rect: 250, 749, 355, 755
      Annotation: 
       Subtype: Link
       Rect: 328, 721, 379, 729
      Annotation: 
       Subtype: Link
       Rect: 243, 666, 440, 674
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 405, 644, 550, 651
      Annotation: 
       Subtype: Link
       Rect: 87, 165, 98, 173
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 159, 144, 170, 152
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 163, 113, 173, 121
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 57, 82, 64, 90
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 71, 82, 78, 90
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 445, 565, 453, 572
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 459, 565, 466, 572
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 394, 523, 404, 531
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 320, 481, 330, 489
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 362, 439, 372, 447
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 372, 324, 387, 332
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 321, 293, 336, 300
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 461, 261, 476, 269
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 454, 188, 469, 196
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 301, 167, 316, 175
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 463, 136, 478, 144
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 340, 83, 355, 91
       Destination: 101
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 243, 517, 257, 525
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 547, 130, 562, 138
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 547, 109, 562, 117
       Destination: 145
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 178, 695, 193, 703
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 241, 559, 256, 567
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 188, 496, 202, 504
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 51, 162, 72, 170
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 66, 99, 97, 107
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 140, 68, 168, 76
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 301, 287, 330, 295
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 301, 256, 322, 264
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 512, 235, 540, 243
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 418, 224, 447, 232
       Destination: 66
      Annotation: 
       Subtype: Link
       Rect: 411, 172, 431, 180
       Destination: 73
      Annotation: 
       Subtype: Link
       Rect: 373, 120, 401, 128
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 508, 109, 537, 117
       Destination: 80
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 131, 172, 159, 180
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 550, 528, 562, 536
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 311, 517, 316, 525
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 365, 507, 387, 515
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 346, 381, 360, 389
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 422, 277, 426, 285
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 428, 277, 437, 285
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 314, 204, 323, 212
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 325, 204, 334, 212
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 354, 99, 369, 107
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 533, 695, 536, 701
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 372, 650, 374, 654
       Destination: 51
    Page: 
     Label: 6
    Page: 
     Label: 7
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 86, 300, 95, 308
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 97, 300, 106, 308
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 419, 408, 550, 416
      Annotation: 
       Subtype: Link
       Rect: 88, 576, 91, 583
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 88, 559, 91, 565
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 88, 542, 91, 548
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 64, 485, 66, 489
       Destination: 80
    Page: 
     Label: 9
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 403, 425, 513, 433
      Annotation: 
       Subtype: Link
       Rect: 317, 382, 552, 388
      Annotation: 
       Subtype: Link
       Rect: 317, 374, 552, 380
      Annotation: 
       Subtype: Link
       Rect: 317, 366, 374, 372
      Annotation: 
       Subtype: Link
       Rect: 317, 358, 552, 364
      Annotation: 
       Subtype: Link
       Rect: 317, 350, 463, 356
      Annotation: 
       Subtype: Link
       Rect: 317, 342, 552, 348
      Annotation: 
       Subtype: Link
       Rect: 317, 334, 552, 340
      Annotation: 
       Subtype: Link
       Rect: 317, 326, 552, 332
      Annotation: 
       Subtype: Link
       Rect: 317, 318, 472, 324
      Annotation: 
       Subtype: Link
       Rect: 317, 310, 552, 316
      Annotation: 
       Subtype: Link
       Rect: 317, 302, 552, 308
      Annotation: 
       Subtype: Link
       Rect: 317, 294, 529, 300
      Annotation: 
       Subtype: Link
       Rect: 317, 286, 552, 292
      Annotation: 
       Subtype: Link
       Rect: 317, 278, 552, 285
      Annotation: 
       Subtype: Link
       Rect: 317, 270, 422, 277
      Annotation: 
       Subtype: Link
       Rect: 317, 262, 552, 269
      Annotation: 
       Subtype: Link
       Rect: 317, 254, 551, 261
      Annotation: 
       Subtype: Link
       Rect: 457, 246, 552, 253
      Annotation: 
       Subtype: Link
       Rect: 317, 238, 522, 245
      Annotation: 
       Subtype: Link
       Rect: 492, 222, 552, 229
      Annotation: 
       Subtype: Link
       Rect: 317, 214, 550, 221
      Annotation: 
       Subtype: Link
       Rect: 317, 206, 326, 213
      Annotation: 
       Subtype: Link
       Rect: 317, 198, 552, 205
      Annotation: 
       Subtype: Link
       Rect: 317, 190, 552, 197
      Annotation: 
       Subtype: Link
       Rect: 317, 183, 489, 189
      Annotation: 
       Subtype: Link
       Rect: 317, 175, 552, 181
      Annotation: 
       Subtype: Link
       Rect: 317, 167, 552, 173
      Annotation: 
       Subtype: Link
       Rect: 317, 159, 449, 165
      Annotation: 
       Subtype: Link
       Rect: 462, 135, 527, 141
      Annotation: 
       Subtype: Link
       Rect: 317, 127, 552, 133
      Annotation: 
       Subtype: Link
       Rect: 317, 119, 552, 125
      Annotation: 
       Subtype: Link
       Rect: 317, 111, 412, 117
      Annotation: 
       Subtype: Link
       Rect: 317, 103, 552, 109
      Annotation: 
       Subtype: Link
       Rect: 317, 95, 461, 101
      Annotation: 
       Subtype: Link
       Rect: 317, 87, 552, 93
      Annotation: 
       Subtype: Link
       Rect: 317, 79, 552, 85
      Annotation: 
       Subtype: Link
       Rect: 317, 71, 552, 77
      Annotation: 
       Subtype: Link
       Rect: 317, 63, 347, 69
      Annotation: 
       Subtype: Link
       Rect: 317, 55, 552, 61
      Annotation: 
       Subtype: Link
       Rect: 317, 47, 552, 53
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 727, 293, 733
      Annotation: 
       Subtype: Link
       Rect: 57, 719, 143, 725
      Annotation: 
       Subtype: Link
       Rect: 57, 711, 293, 717
      Annotation: 
       Subtype: Link
       Rect: 57, 703, 293, 709
      Annotation: 
       Subtype: Link
       Rect: 57, 695, 137, 701
      Annotation: 
       Subtype: Link
       Rect: 271, 687, 293, 693
      Annotation: 
       Subtype: Link
       Rect: 57, 679, 111, 686
      Annotation: 
       Subtype: Link
       Rect: 228, 663, 293, 670
      Annotation: 
       Subtype: Link
       Rect: 57, 655, 251, 662
      Annotation: 
       Subtype: Link
       Rect: 326, 727, 562, 733
      Annotation: 
       Subtype: Link
       Rect: 326, 719, 475, 725
      Annotation: 
       Subtype: Link
       Rect: 326, 711, 562, 717
      Annotation: 
       Subtype: Link
       Rect: 326, 703, 562, 709
      Annotation: 
       Subtype: Link
       Rect: 326, 695, 562, 701
      Annotation: 
       Subtype: Link
       Rect: 326, 687, 384, 693
      Annotation: 
       Subtype: Link
       Rect: 326, 679, 562, 686
      Annotation: 
       Subtype: Link
       Rect: 326, 671, 562, 678
      Annotation: 
       Subtype: Link
       Rect: 326, 663, 562, 670
      Annotation: 
       Subtype: Link
       Rect: 326, 655, 521, 662
  Checksum: b1088a89
   Type: CRC32
  Checksum: c190bd08d747615ce52c1f89543e7a7a
   Type: MD5
  Checksum: 27b8aa56322b47b0ea063c9ce95d18ffe25b8b43
   Type: SHA-1