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Keywords: measurable (minimal) residual disease, T-cell acute lymphoblastic leukemia, oncogenetics, NOTCH1, flow cytometry, pediatrics, risk-factors Author: Nerea Vega-Garcı́a and Mireia Camós Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Feb 1 13:05:37 2021 CET ModDate: Mon Feb 1 14:46:26 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 675719 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ESXYYA+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 37 0 ZAGDIL+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 42 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 55 0 IUCTOB+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 57 0 PJVPGH+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 63 0 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Outlines: Item: Title: Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic 䰀攀甀欀攀洀椀愀 椀渀 䌀漀渀猀攀挀甀琀椀瘀攀 匀䔀䠀伀倀 倀爀漀琀漀挀漀氀猀 圀栀攀爀攀愀猀 琀栀攀 䤀洀瀀愀挀琀 漀昀 伀渀挀漀最攀渀攀琀椀挀猀 䐀攀瀀攀渀搀猀 漀渀 吀爀攀愀琀洀攀渀琩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㈹‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㔯䅣瑩潮⽇潔漯偲敶′㠠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Study Design, Cohort of Patients, and Therapeutic Protocols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: FCM Characterization and MRD Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Mutation Screening and CNA Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Outcome Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Ethical Aspects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Molecular Findings and Association With Clinical Features at Diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Patients' Outcome in Consecutive SEHOP Protocols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: FCM-MRD Predicted Outcome in Consecutive SEHOP Protocols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Oncogenetics Impact on Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Prognostic Impact of Classical Risk Factors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Use of a Clinical Prognostic Scores Combining Classical and New Risk Factors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Participant Investigators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Info: Title: Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment Author: Nerea Vega-Garcı́a and Mireia Camós Subject: Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, and most protocols rely on measurable residual disease (MRD) assessment. Keywords: measurable (minimal) residual disease, T-cell acute lymphoblastic leukemia, oncogenetics, NOTCH1, flow cytometry, pediatrics, risk-factors Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Feb 01 13:35:37 CET 2021 ModDate: Mon Feb 01 15:16:26 CET 2021 ID: 0xf237af1fe13e638e0406ec5ea7837464, 0xbc78afb09f131147b8fa1f868fd4049f Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1324 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 632 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: SVFRZA+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: SVFRZA+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 860, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UADLTO+MTSYB FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: UADLTO+MTSYB Flags: Symbolic, AllCap FontBBox: 0, 0, 724, 387 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ESXYYA+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: ESXYYA+HelveticaNeueLTStd-Bd Flags: Serif, Symbolic FontBBox: -9, -214, 925, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IPUSCC+MTSY FontSubset: true FirstChar: 2 LastChar: 68 FontDescriptor: FontName: IPUSCC+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BZLTZV+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: BZLTZV+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 1003, 712 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OUMSOA+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: OUMSOA+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IUCTOB+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 250 FontDescriptor: FontName: IUCTOB+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 907 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ZAGDIL+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 237 FontDescriptor: FontName: ZAGDIL+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -13, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ENDSWG+RMTMI FontSubset: true FirstChar: 22 LastChar: 62 FontDescriptor: FontName: ENDSWG+RMTMI Flags: Symbolic FontBBox: 0, -188, 683, 455 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PJVPGH+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: PJVPGH+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -92, -205, 891, 928 FontFile3: true Encoding: WinAnsiEncoding XMP: 2021-02-01T17:35:37+05:30 LaTeX with hyperref package + hypdvips 2021-02-01T19:16:26+05:30 2021-02-01T19:16:26+05:30 application/pdf Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, and most protocols rely on measurable residual disease (MRD) assessment. 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