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Selmaj Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sun Jun 13 06:19:04 2021 CEST ModDate: Thu Jul 1 06:57:01 2021 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 700329 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CVMGIL+CharisSIL CID TrueType Identity-H yes yes yes 724 0 PKWHVO+CharisSIL-Italic CID TrueType Identity-H yes yes yes 727 0 ILYPDJ+STIX-Italic Type 1C Custom yes yes yes 730 0 PGYJQK+STIX-Regular Type 1C Custom yes yes yes 738 0 NKTVMP+ArialUnicodeMS CID TrueType Identity-H yes yes yes 741 0 ERNRUV+TeX_CM_Roman Type 1C Builtin yes yes yes 722 0 HTHNSB+Univers Type 1C Builtin yes yes yes 746 0 AEAUNO+CharisSIL CID TrueType Identity-H yes yes yes 769 0 VVCCGG+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 60 0 NRJSCY+CharisSIL-Bold CID TrueType Identity-H yes yes yes 68 0 SEKBTC+CharisSIL-Italic CID TrueType Identity-H yes yes yes 45 0 MFLPPM+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 97 0 ADUWYD+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 225 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-30 02:38:30 CEST RepresentationInformation: 276012.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-28 11:53:04 CEST Size: 700329 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 832 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Ozanimod in relapsing multiple sclerosis: Pooled safety results from the clinical development program Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2 Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 2.1 Ozanimod clinical trial study designs and RMS populations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.2 Safety assessments and outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.3 Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.4 Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: 3.1 Study population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 3.2 TEAEs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3.3 Cardiovascular effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3.4 Hepatic effects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 3.5 Macular edema Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 3.6 ALC reductions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 3.7 Infections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3.8 Malignancies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 3.9 Pulmonary function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3.10 Potential drug interactions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 3.11 Pregnancy outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 3.12 Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 3.13 Clinical rebound Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 5 Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Info: Title: Ozanimod in relapsing multiple sclerosis: Pooled safety results from the clinical development program Author: Krzysztof W. Selmaj Subject: Multiple Sclerosis and Related Disorders, 51 (2021) 102844. doi:10.1016/j.msard.2021.102844 Keywords: Multiple sclerosis,Ozanimod,Safety,Adverse events,Clinical trials Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sun Jun 13 06:19:04 CEST 2021 ModDate: Thu Jul 01 07:27:01 CEST 2021 ID: 0x0caddd27b4b8e5f1ccbd0e6f56463afc, 0xa262f4c1bdb7e743a2e6b586e241fd7b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type0: Font: BaseFont: ADUWYD+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: CVMGIL+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: NRJSCY+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: NKTVMP+ArialUnicodeMS Encoding: Identity-H ToUnicode: true Font: BaseFont: PKWHVO+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MFLPPM+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: MFLPPM+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: ERNRUV+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: ERNRUV+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: PGYJQK+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: PGYJQK+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HTHNSB+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: HTHNSB+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: ILYPDJ+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: ILYPDJ+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: PKWHVO+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PKWHVO+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: NKTVMP+ArialUnicodeMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NKTVMP+ArialUnicodeMS Flags: Nonsymbolic FontBBox: -1011, -279, 2260, 1074 FontFile2: true Font: BaseFont: ADUWYD+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ADUWYD+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: CVMGIL+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CVMGIL+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: NRJSCY+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NRJSCY+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true XMP: application/pdf doi:10.1016/j.msard.2021.102844 Ozanimod in relapsing multiple sclerosis: Pooled safety results from the clinical development program Krzysztof W. Selmaj Jeffrey A Cohen Giancarlo Comi Amit Bar-Or Douglas L Arnold Lawrence Steinman Hans Peter Hartung Xavier Montalban Eva Kubala Havrdova Bruce A.C. Cree Neil Minton James K Sheffield Ning Ding Ludwig Kappos Multiple sclerosis Ozanimod Safety Adverse events Clinical trials Multiple Sclerosis and Related Disorders, 51 (2021) 102844. doi:10.1016/j.msard.2021.102844 Elsevier journal Multiple Sclerosis and Related Disorders © 2021. 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