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Keywords: polypill fixed-dose combination, secondary prevention, cardiovascular disease, cerebrovascular disease Author: Lilian Grigorian-Shamagian Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Aug 18 10:38:04 2021 CEST ModDate: Wed Aug 18 13:36:46 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 2042762 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JBYOJY+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 39 0 RAOXMV+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 44 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 57 0 GNLWMA+HelveticaNeueLTStd-LtIt Type 1C WinAnsi yes yes no 59 0 FOQAVE+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 64 0 HHDBKU+MinionPro-Regular Type 1C Custom yes yes no 72 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 75 0 APORMK+MinionPro-Bold Type 1C Custom yes yes no 120 0 CVSDCX+MTSY Type 1C Custom yes yes no 126 0 EATTMK+CMR5 Type 1C WinAnsi yes yes no 138 0 XEYEKL+HelveticaNeueLTStd-Md Type 1C WinAnsi yes yes no 187 0 GBAUGV+RMTMIB Type 1C WinAnsi yes yes no 189 0 NCTVQD+MinionPro-It Type 1C WinAnsi yes yes no 240 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-10 02:43:45 CEST RepresentationInformation: 291149.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-09 12:59:36 CEST Size: 2042762 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 321 FreeObjects: 16 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Practical Decision Algorithms for the Use of the Cardiovascular Polypill in Secondary Prevention in Europe Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Development Of The Algorithms Destination: section*.3 Item: Title: What Is the Patient Profile Suitable For the CNIC-POLYPILL? Destination: section*.4 Item: Title: Secondary Prevention After An Acute Coronary Syndrome Destination: section*.5 Children: Item: Title: According to the Statin Tolerance Levels Destination: section*.6 Item: Title: Statin Naïve Patients Destination: section*.7 Item: Title: Patients Previously Treated With Statins Destination: section*.8 Item: Title: Secondary Prevention in Chronic Cardiovascular Disease Destination: section*.9 Children: Item: Title: Patients With Suboptimal Low-Density Lipoprotein Cholesterol Levels Destination: section*.10 Children: Item: Title: Practical Decision Algorithms for the Use of the Cardiovascular Polypill in Secondary Prevention in Europe Destination: section*.11 Item: Title: Patients on Previous Treatment With ASA/ACEI or ARB With a High-Intensity Statin (or Equipotent to 80mg of Atorvastatin) Destination: section*.12 Item: Title: Patients With Suboptimal Blood Pressure Levels Destination: section*.13 Children: Item: Title: Patients on ASA/Statin but Not on BP-Lowering Treatment or Low Doses of ACEI or ARB Destination: section*.14 Item: Title: Patients on ASA/Statin/ACEI or ARB Plus a CCB or a Diuretic Destination: section*.15 Item: Title: Patients on ASA/Statin/ACEI or ARB Plus a CCB and a Diuretic Destination: section*.16 Item: Title: How to Reduce Polypharmacy in Patients With Well-Controlled Blood Pressure and Low-Density Lipoprotein Cholesterol Destination: section*.17 Children: Item: Title: Patients Treated With ASA/Statin/ACEI or ARB Only (From 3 to 1 Pill) Destination: section*.18 Item: Title: Patients Treated With ASA/Statin/ACEI or ARB Plus Additional Lipid-Lowering Drugs (From 4/5 to 2/3 Pills) Destination: section*.19 Item: Title: Patients Treated With ASA/Statin/ACEI or ARB Plus Additional BP-Lowering Drugs (From 3/4/5 to 2 Pills) Destination: section*.20 Item: Title: Limitations Destination: section*.21 Item: Title: Conclusions Destination: section*.22 Item: Title: Data Availability Statement Destination: section*.23 Item: Title: Author Contributions Destination: section*.24 Item: Title: Funding Destination: section*.25 Item: Title: Acknowledgments Destination: section*.26 Item: Title: References Destination: section*.27 Info: Title: Practical Decision Algorithms for the Use of the Cardiovascular Polypill in Secondary Prevention in Europe Author: Lilian Grigorian-Shamagian Subject: The main objective of cardiovascular disease (CVD) prevention is to reduce morbidity and mortality. Keywords: polypill fixed-dose combination, secondary prevention, cardiovascular disease, cerebrovascular disease Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Aug 18 11:08:04 CEST 2021 ModDate: Wed Aug 18 14:06:46 CEST 2021 ID: 0x27c01631cb95379ef86a184949a3f48e, 0x62b2cfb150179640a67fbbce4a5e33c8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1863 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1403 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1461 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1376 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: FOQAVE+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: FOQAVE+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -64, -205, 891, 928 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JBYOJY+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 239 FontDescriptor: FontName: JBYOJY+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -41, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HHDBKU+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: HHDBKU+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EATTMK+CMR5 FontSubset: true FirstChar: 36 LastChar: 36 FontDescriptor: FontName: EATTMK+CMR5 Flags: Nonsymbolic, AllCap FontBBox: 0, -56, 583, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: RAOXMV+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 150 FontDescriptor: FontName: RAOXMV+HelveticaNeueLTStd-Lt Flags: Serif, Symbolic FontBBox: -30, -214, 773, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NCTVQD+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 241 FontDescriptor: FontName: NCTVQD+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: APORMK+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: APORMK+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 724, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNLWMA+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: GNLWMA+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 858, 907 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: XEYEKL+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: XEYEKL+HelveticaNeueLTStd-Md Flags: Nonsymbolic FontBBox: -8, -205, 938, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBAUGV+RMTMIB FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: GBAUGV+RMTMIB Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 682, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CVSDCX+MTSY FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: CVSDCX+MTSY Flags: Symbolic FontBBox: 0, -133, 670, 551 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-08-18T14:08:04+05:30 LaTeX with hyperref package + hypdvips 2021-08-18T17:06:46+05:30 2021-08-18T17:06:46+05:30 application/pdf The main objective of cardiovascular disease (CVD) prevention is to reduce morbidity and mortality. 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