16b0d2c4078a5d6b649986211684c6a6 pmc_8555491.pdf 578985cc2fb1d6d6a2f8417b48c8e72d63e6e82f pmc_8555491.pdf c946e800fb2995c020255b349adbe397856fc462995f8e9affa588359cc00de4 pmc_8555491.pdf Title: The Second Wind in McArdle Patients: Fitness Matters Subject: Background: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. Keywords: glycogenosis type 5, myophosphorylase deficiency, cardiorespiratory fitness, ventilatory threshold, physical activity second wind in McArdles 2 Author: Carmen Fiuza-Luces Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Oct 11 12:56:11 2021 CEST ModDate: Mon Oct 11 16:46:33 2021 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 764279 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NYHIRG+MinionPro-Regular Type 1 Custom yes yes no 24 0 VGXTMY+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 25 0 MCVPQC+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 26 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 31 0 ZODYSA+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 32 0 ZNERZT+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 33 0 FLVGVW+MTSYN Type 1 Builtin yes yes no 34 0 XODHDR+RBLMI Type 1 Builtin yes yes no 35 0 BJKGRS+MinionPro-It Type 1 Custom yes yes no 108 0 ZVATOY+MinionPro-Bold Type 1 Custom yes yes no 172 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-04 02:37:31 CEST RepresentationInformation: pmc_8555491.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-06-03 16:26:26 CEST Size: 764279 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 425 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The Second Wind in McArdle Patients: Fitness Matters Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Participants Item: Title: Exercise Tests Item: Title: Statistics Analysis Item: Title: Results Item: Title: Discussion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Supplementary Material Item: Title: References Info: Title: The Second Wind in McArdle Patients: Fitness Matters Author: Carmen Fiuza-Luces Subject: Background: The “second wind” (SW) phenomenon commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6 10 min has elapsed is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. Keywords: glycogenosis type 5, myophosphorylase deficiency, cardiorespiratory fitness, ventilatory threshold, physical activity second wind in McArdles 2 Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Mon Oct 11 13:26:11 CEST 2021 ModDate: Mon Oct 11 17:16:33 CEST 2021 ID: 0xaf63c14e75cb9751b78aded54c198c4e, 0xb16e651da5ee484cb98a67f8d9deafd1 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ZODYSA+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: ZODYSA+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZNERZT+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: ZNERZT+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FLVGVW+MTSYN FontSubset: true FirstChar: 0 LastChar: 24 FontDescriptor: FontName: FLVGVW+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: XODHDR+RBLMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: XODHDR+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: NYHIRG+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: NYHIRG+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VGXTMY+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: VGXTMY+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MCVPQC+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 237 FontDescriptor: FontName: MCVPQC+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: BJKGRS+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: BJKGRS+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZVATOY+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: ZVATOY+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true XMP: glycogenosis type 5, myophosphorylase deficiency, cardiorespiratory fitness, ventilatory threshold, physical activity second wind in McArdles 2 pdfTeX-1.40.15 1.5 application/pdf fphys-12-744632.tex The Second Wind in McArdle Patients: Fitness Matters Background: The “second wind” (SW) phenomenon—commonly referring to both an initial period of marked intolerance to dynamic exercise (e.g., brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i.e., the actual “SW”) until 6–10 min has elapsed—is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. 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