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Title:           Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis
Subject:         Gastroenterology, 160 (2021) 797-814. doi:10.1053/j.gastro.2020.10.031
Author:          Juan F. Burgueño
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      Title: Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis
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        Title: Methods
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         Item: 
          Title: Animals
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         Item: 
          Title: Germ-Free Mice and Microbial Engraftment
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         Item: 
          Title: Induction of Tumorigenesis
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         Item: 
          Title: Collection of Tissue Samples
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         Item: 
          Title: Isolation of Colonic Epithelial Cells and Colonoid Preparation
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         Item: 
          Title: Measurement of Hydrogen Peroxide Production
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         Item: 
          Title: Statistical Analysis
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        Title: Results
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         Item: 
          Title: Dysregulation of Toll-Like Receptor 4 Is Associated With Overexpression of DUOX2 and NOX1
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         Item: 
          Title: Bacterial Signaling Through Toll-Like Receptor 4 Regulates Expression of Duox2 and Nox1 in Colonic Epithelial Cells In Vivo ...
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         Item: 
          Title: Epithelial Toll-Like Receptor 4 Activation Induces H2O2 Production in a DUOX2-Dependent Manner
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         Item: 
          Title: Colitis-Associated Dysplasia and Tumorigenesis Are Associated With Increased H2O2 Synthesis by Colonic Epithelial Cells
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          Title: Both DUOX2 Signaling and the Microbiome Are Required for Toll-Like Receptor-4–Dependent Colonic Tumorigenesis
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         Item: 
          Title: Toll-Like Receptor 4–Shaped Microbiota Transfers Epithelial Redox Activity and Susceptibility to Tumorigenesis
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        Title: Supplementary Methods
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          Title: Histologic Evaluation
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          Title: In Situ Hybridization and Immunofluorescence
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          Title: Quantitative Polymerase Chain Reaction Analysis and Microarray
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          Title: DNA Extraction and 16S Ribosomal RNA Sequencing
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          Title: Bioinformatics
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   Type: CRC32
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