a55f99ed35f5a84b86c697f34f50bed6 327602.pdf 802fb7373846727a3a378ff0ef7599009287a174 327602.pdf 4109ee3f3d3f6559a39eee2ff6ea4f34d4f0afecadf2ae500d0390ec157abab2 327602.pdf Title: Brentuximab-Induced Peripheral Neurotoxicity:A Multidisciplinary Approach to Manage an Emerging Challenge in Hodgkin Lymphoma Therapy Subject: Brentuximab vedotin (BV) is an anti-CD30 antibody–drug conjugate approved to treat classical Hodgkin lymphoma (HL). BV-induced peripheral neurotoxicity (BVIN) is one of the greatest concerns for haematologists treating HL for several reasons. First, BVIN is highly frequent. Most patients receiving BV will experience some degree of BVIN, resulting in the primary reason for dose modification or discontinuation of HL therapy. Second, BV produces sensory, motor, and/or autonomic peripheral nerve dysfunction, which can present as severe, disabling forms of BVIN—predominantly motor—in some patients. Third, although largely reversible, BVIN may persist months or years after treatment and thereby become a major issue in HL survivorship. BVIN may, therefore, negatively affect the quality of life and work-life of often young patients with HL, in whom long-term survival is expected. Currently, the only strategy for BVIN includes dose adjustments and treatment discontinuation; however, this could interfere with LH therapy efficacy. In this setting, early recognition and adequate management of BVIN are critical in improving clinical outcomes. Careful neurologic monitoring may allow accurate diagnoses and gradation of ongoing forms of BVIN presentation. This review analysed current, available data on epidemiology, pathophysiology, patient- and treatment-related risk factors, clinical and neurophysiologic phenotypes, and management in patients with HL. Furthermore, this review specifically addresses limitations posed by BVIN assessments in clinical practice and provides skills and tools to improve neurologic assessments in these patients. Integrating this neurotoxic drug in clinical practice requires a multidisciplinary approach to avoid or minimise neurotoxicity burden in survivors of HL. Keywords: Hodgkin lymphoma; brentuximab vedotin; neurotoxicity; peripheral neuropathy; chemotherapy-induced peripheral neuropathy; multidisciplinary Author: Roser Velasco, Eva Domingo-Domenech and Anna Sureda Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Dec 6 15:51:38 2021 CET ModDate: Mon Dec 6 16:29:03 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 24 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1091600 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JWHXOC+VnURWPalladioL Type 1 Custom yes yes no 10 0 YJLWYF+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 EZFTCD+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 OHRKCZ+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 33 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 55 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 59 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 63 0 MSSEIU+CMSY10 Type 1 Builtin yes yes no 75 0 ICBUDW+URWPalladioL-BoldItal Type 1 Custom yes yes no 82 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes no 86 0 CKBPVA+EURM10 Type 1 Builtin yes yes no 102 0 PGZALO+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 112 0 ARQTJS+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 116 0 GNQYPG+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 120 0 PGZALO+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 145 0 ARQTJS+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 149 0 GNQYPG+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 153 0 PGZALO+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 166 0 ARQTJS+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 170 0 GNQYPG+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 174 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-04-11 04:25:22 CEST RepresentationInformation: 327602.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-04-10 12:31:29 CEST Size: 1091600 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 739 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Epidemiology of BVIN Destination: section.2 Item: Title: Mechanisms of Brentuximab-Induced Peripheral Neurotoxicity Destination: section.3 Item: Title: Types and Forms of BVIN Presentation and Timing Destination: section.4 Item: Title: Risk Factors for BVIN Destination: section.5 Item: Title: Early Diagnosis and Management of BVIN Destination: section.6 Children: Item: Title: Early Detection and Timely Assessment of BVIN Are Crucial in Achieving a Better Outcome Destination: subsection.6.1 Item: Title: Proper Management of BVIN Requires a Multidisciplinary Approach Destination: subsection.6.2 Children: Item: Title: Dose Adjustments Destination: subsubsection.6.2.1 Item: Title: Patients Destination: subsubsection.6.2.2 Item: Title: Multidisciplinary Approach Destination: subsubsection.6.2.3 Item: Title: Pharmacologic Treatment of BVIN Destination: subsubsection.6.2.4 Item: Title: Prognosis and Long-Term Outcomes of BVIN Destination: section.7 Item: Title: Conclusions Destination: section.8 Item: Title: References Destination: section.8 Info: Title: Brentuximab-Induced Peripheral Neurotoxicity:A Multidisciplinary Approach to Manage an Emerging Challenge in Hodgkin Lymphoma Therapy Author: Roser Velasco, Eva Domingo-Domenech and Anna Sureda Subject: Brentuximab vedotin (BV) is an anti-CD30 antibody drug conjugate approved to treat classical Hodgkin lymphoma (HL). BV-induced peripheral neurotoxicity (BVIN) is one of the greatest concerns for haematologists treating HL for several reasons. First, BVIN is highly frequent. Most patients receiving BV will experience some degree of BVIN, resulting in the primary reason for dose modification or discontinuation of HL therapy. Second, BV produces sensory, motor, and/or autonomic peripheral nerve dysfunction, which can present as severe, disabling forms of BVIN predominantly motor in some patients. Third, although largely reversible, BVIN may persist months or years after treatment and thereby become a major issue in HL survivorship. BVIN may, therefore, negatively affect the quality of life and work-life of often young patients with HL, in whom long-term survival is expected. Currently, the only strategy for BVIN includes dose adjustments and treatment discontinuation; however, this could interfere with LH therapy efficacy. In this setting, early recognition and adequate management of BVIN are critical in improving clinical outcomes. Careful neurologic monitoring may allow accurate diagnoses and gradation of ongoing forms of BVIN presentation. This review analysed current, available data on epidemiology, pathophysiology, patient- and treatment-related risk factors, clinical and neurophysiologic phenotypes, and management in patients with HL. Furthermore, this review specifically addresses limitations posed by BVIN assessments in clinical practice and provides skills and tools to improve neurologic assessments in these patients. Integrating this neurotoxic drug in clinical practice requires a multidisciplinary approach to avoid or minimise neurotoxicity burden in survivors of HL. Keywords: Hodgkin lymphoma; brentuximab vedotin; neurotoxicity; peripheral neuropathy; chemotherapy-induced peripheral neuropathy; multidisciplinary Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Dec 06 15:51:38 CET 2021 ModDate: Mon Dec 06 16:29:03 CET 2021 ID: 0x724076a6a33ecdcfe53a3c7608aa31c9, 0x724076a6a33ecdcfe53a3c7608aa31c9 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ICBUDW+URWPalladioL-BoldItal FontSubset: true FirstChar: 78 LastChar: 78 FontDescriptor: FontName: ICBUDW+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EZFTCD+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: EZFTCD+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RIJDHR+CMBSY10 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: 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