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OGBKHP+CaeciliaLTStd-R Type 1C Custom yes yes yes 477 0 OGCEML+MTMI Type 1C Custom yes yes yes 187 0 OGCHPI+CaeciliaLTStd-BI Type 1C Custom yes yes yes 191 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-10 02:56:52 CET RepresentationInformation: pmc_33987651.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-07-26 03:39:02 CEST Size: 2006070 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'afn1' cannot be found Offset: 1980076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'afn1' cannot be found Offset: 1980076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'afn2' cannot be found Offset: 1980076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'afn2' cannot be found Offset: 1980076 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 547 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Novel Dent disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: Expression and subcellular localization of ClC-5 mutants p.Val523del, p.Glu527Asp and p.(Ile524Lys) in RPTEC/TERT1 cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: ClC-5 p.Ile524Lys mutant, but not p.Val523del or p.(Glu527Asp) presents an altered glycosylation pattern Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: CLCN5 silencing or re-introduction of p.Val523del, p.Glu527Asp and p.(Ile524Lys) ClC-5 mutants impairs albumin endocytosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: CLCN5 silencing or re-introduction of ClC-5 mutations p.Val523del, p.Glu527Asp and p.(Ile524Lys) alter the global gene expression profile of RPTEC/TERT1 cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: CLCN5 silencing and ClC-5 mutations downregulate epithelial markers expression, increase cell proliferation and impair cell-to-substrate adhesion and collective cell migration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Cell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Gene silencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Vectors and site-directed mutagenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: RNA extraction and qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Western blot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Immunocytochemistry 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