e8e048ac83f45cbeaeba4bbced5f79df pmc_34228394.pdf a3ab52a593c4afc536a43329f06663e1835873cf pmc_34228394.pdf 82c3aab77aac0f2494c68752d0d8bb36c278942a8a7a6590d9d3b97a31a6c3b1 pmc_34228394.pdf Title: Early diarrhoea under sorafenib as a marker to consider the early migration to second‐line drugs Creator: Arbortext Advanced Print Publisher 11.2.5182/W-x64 Producer: PDFlib+PDI 9.1.2p4 (C++/Win64) CreationDate: Tue Jul 13 01:04:28 2021 CEST ModDate: Tue Jul 13 01:06:37 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 350260 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UANAYF+Lato-Regular Type 1C Custom yes yes yes 359 0 VFKDMN+STIX-Bold Type 1C Custom yes yes yes 363 0 QYTUOU+Lato-Bold Type 1C Custom yes yes yes 367 0 RFUTVA+Lato-Bold CID TrueType Identity-H yes yes yes 369 0 REJLSS+Lato-Regular CID TrueType Identity-H yes yes yes 377 0 VOBMBM+STIXGeneral Type 1C Custom yes yes yes 373 0 HGKJER+Lato-Italic Type 1C Custom yes yes yes 388 0 JBWIIS+STIX-Regular Type 1C Custom yes yes yes 391 0 TeX_CM_Maths_Symbols Type 1 Builtin yes no yes 203 0 ESSTIX-Two Type 1 Builtin yes no yes 206 0 NLJANW+Lato-BoldItalic Type 1C Custom yes yes yes 211 0 KRXPGZ+Lato-Italic CID TrueType Identity-H yes yes yes 217 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-21 02:41:39 CEST RepresentationInformation: pmc_34228394.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:37 CEST Size: 350260 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ueg212111-sup-0001' cannot be found Offset: 333429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ueg212111-sup-0001' cannot be found Offset: 333429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ueg212111-sup-0001' cannot be found Offset: 333429 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ueg212111-sup-0001' cannot be found Offset: 333429 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 502 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Early diarrhoea under sorafenib as a marker to consider the early migration to second‐line drugs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: MATERIALS AND METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Treatment and follow up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Baseline characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Diarrhoea as a predictor of OS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Diarrhoea and radiological progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: CONFLICT OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: DATA AVAILABILITY STATEMENT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: Early diarrhoea under sorafenib as a marker to consider the early migration to second‐line drugs Creator: Arbortext Advanced Print Publisher 11.2.5182/W-x64 Producer: PDFlib+PDI 9.1.2p4 (C++/Win64) CreationDate: Tue Jul 13 01:34:28 CEST 2021 ModDate: Tue Jul 13 01:36:37 CEST 2021 ID: 0x38f6710f4932f95133be24d3420080c3, 0xff1dcd9525c2a946b7bd149a1ef52d57 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 945 ImageHeight: 833 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: RFUTVA+Lato-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: REJLSS+Lato-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: KRXPGZ+Lato-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NLJANW+Lato-BoldItalic FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: NLJANW+Lato-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -110, -250, 1049, 937 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HGKJER+Lato-Italic FontSubset: true FirstChar: 1 LastChar: 44 FontDescriptor: FontName: HGKJER+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -115, -250, 1024, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VOBMBM+STIXGeneral FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: VOBMBM+STIXGeneral Flags: Nonsymbolic FontBBox: -178, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JBWIIS+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JBWIIS+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UANAYF+Lato-Regular FontSubset: true FirstChar: 1 LastChar: 92 FontDescriptor: FontName: UANAYF+Lato-Regular Flags: Nonsymbolic FontBBox: -94, -183, 1117, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VFKDMN+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: VFKDMN+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TeX_CM_Maths_Symbols FirstChar: 1 LastChar: 255 FontDescriptor: FontName: TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true ToUnicode: true Font: BaseFont: ESSTIX-Two FirstChar: 33 LastChar: 168 FontDescriptor: FontName: ESSTIX-Two Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true ToUnicode: true Font: BaseFont: QYTUOU+Lato-Bold FontSubset: true FirstChar: 1 LastChar: 68 FontDescriptor: FontName: QYTUOU+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -89, -181, 1143, 937 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: RFUTVA+Lato-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RFUTVA+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -603, -285, 1344, 1100 FontFile2: true Font: BaseFont: KRXPGZ+Lato-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KRXPGZ+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -502, -269, 1291, 1078 FontFile2: true Font: BaseFont: REJLSS+Lato-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: REJLSS+Lato-Regular Flags: Nonsymbolic FontBBox: -547, -269, 1343, 1079 FontFile2: true XMP: 2021-07-13T04:34:28+05:30 Arbortext Advanced Print Publisher 11.2.5182/W-x64 2021-07-13T04:36:37+05:30 2021-07-13T04:36:37+05:30 PDFlib+PDI 9.1.2p4 (C++/Win64) False 10.1002/ueg2.12111 10.1002/(ISSN)2050-6414 3 PStill version 1.84.42 VoR 10.1002/ueg2.12111 application/pdf Early diarrhoea under sorafenib as a marker to consider the early migration to second‐line drugs uuid:a479264a-7080-4fb4-90e2-0c4c30960c95 uuid:030aba01-ec68-44af-83e5-bf08708eb0be Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 62, 729, 127, 736 Flags: No flags set Annotation: Subtype: Link Rect: 163, 598, 168, 610 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 171, 593, 179, 604 Flags: No flags set Annotation: Subtype: Link Rect: 280, 598, 285, 610 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 288, 593, 296, 604 Flags: No flags set Annotation: Subtype: Link Rect: 384, 598, 390, 610 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 392, 593, 401, 604 Flags: No flags set Annotation: Subtype: Link Rect: 500, 598, 505, 610 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 508, 593, 516, 604 Flags: No flags set Annotation: Subtype: Link Rect: 194, 580, 199, 592 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 201, 575, 210, 586 Flags: No flags set Annotation: Subtype: Link Rect: 367, 580, 372, 592 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 375, 575, 384, 586 Flags: No flags set Annotation: Subtype: Link Rect: 475, 580, 480, 592 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 483, 575, 491, 586 Flags: No flags set Annotation: Subtype: Link Rect: 122, 562, 127, 574 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 130, 557, 138, 569 Flags: No flags set Annotation: Subtype: Link Rect: 241, 562, 246, 574 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 398, 562, 404, 574 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 406, 557, 415, 569 Flags: No flags set Annotation: Subtype: Link Rect: 511, 562, 516, 574 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 136, 544, 141, 556 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 234, 544, 239, 556 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 241, 539, 250, 551 Flags: No flags set Annotation: Subtype: Link Rect: 367, 544, 373, 556 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 375, 539, 384, 551 Flags: No flags set Annotation: Subtype: Link Rect: 488, 544, 493, 556 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 496, 539, 504, 551 Flags: No flags set Annotation: Subtype: Link Rect: 105, 526, 110, 538 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 113, 521, 122, 533 Flags: No flags set Annotation: Subtype: Link Rect: 205, 526, 210, 538 Flags: No flags set Destination: 301 Annotation: Subtype: Link Rect: 213, 521, 221, 533 Flags: No flags set Annotation: Subtype: Link Rect: 66, 258, 125, 265 Flags: No flags set Annotation: Subtype: Link Rect: 141, 258, 181, 265 Flags: No flags set Annotation: Subtype: Link Rect: 45, 248, 55, 255 Flags: No flags set Annotation: Subtype: Link Rect: 171, 595, 179, 604 Flags: No flags set Annotation: Subtype: Link Rect: 288, 595, 296, 604 Flags: No flags set Annotation: Subtype: Link Rect: 392, 595, 401, 604 Flags: No flags set Annotation: Subtype: Link Rect: 508, 595, 516, 604 Flags: No flags set Annotation: Subtype: Link Rect: 201, 577, 210, 586 Flags: No flags set Annotation: Subtype: Link Rect: 375, 577, 384, 586 Flags: No flags set Annotation: Subtype: Link Rect: 483, 577, 491, 586 Flags: No flags set Annotation: Subtype: Link Rect: 130, 560, 138, 568 Flags: No flags set Annotation: Subtype: Link Rect: 406, 560, 415, 568 Flags: No flags set Annotation: Subtype: Link Rect: 241, 542, 250, 550 Flags: No flags set Annotation: Subtype: Link Rect: 375, 542, 384, 550 Flags: No flags set Annotation: Subtype: Link Rect: 496, 542, 504, 550 Flags: No flags set Annotation: Subtype: Link Rect: 113, 524, 122, 532 Flags: No flags set Annotation: Subtype: Link Rect: 213, 524, 221, 532 Flags: No flags set Annotation: Subtype: Link Rect: 406, 35, 517, 42 Flags: No flags set Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 134, 538, 138, 546 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 147, 525, 150, 533 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 262, 525, 266, 533 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 73, 512, 77, 520 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 145, 512, 148, 520 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 284, 499, 288, 507 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 112, 486, 116, 494 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 284, 447, 288, 455 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 101, 434, 105, 442 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 270, 434, 273, 442 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 171, 421, 174, 429 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 139, 201, 156, 209 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 87, 175, 110, 183 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 427, 563, 434, 571 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 378, 120, 387, 128 Flags: No flags set Destination: null Annotation: Subtype: Link Rect: 325, 84, 340, 92 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 459, 68, 468, 76 Flags: No flags set Destination: null Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 91, 667, 98, 675 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 67, 81, 72, 89 Flags: No flags set Destination: 56 Annotation: Subtype: Link Rect: 320, 612, 325, 620 Flags: No flags set Destination: 62 Annotation: Subtype: Link Rect: 332, 547, 341, 555 Flags: No flags set Destination: null Annotation: Subtype: Link Rect: 423, 417, 432, 425 Flags: No flags set Destination: null Annotation: Subtype: Link Rect: 331, 210, 336, 218 Flags: No flags set Destination: 66 Annotation: Subtype: Link Rect: 461, 210, 465, 218 Flags: No flags set Destination: 66 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 526, 110, 549, 118 Flags: No flags set Destination: 96 Page: Sequence: 5 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 270, 252, 285, 260 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 281, 214, 288, 222 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 215, 136, 222, 144 Flags: No flags set Destination: 96 Annotation: Subtype: Link Rect: 381, 68, 392, 76 Flags: No flags set Annotation: Subtype: Link Rect: 392, 68, 535, 76 Flags: No flags set Annotation: Subtype: Link Rect: 355, 55, 367, 63 Flags: No flags set Annotation: Subtype: Link Rect: 367, 55, 509, 63 Flags: No flags set Annotation: Subtype: Link Rect: 381, 70, 389, 78 Flags: No flags set Annotation: Subtype: Link Rect: 355, 57, 364, 65 Flags: No flags set Annotation: Subtype: Link Rect: 88, 371, 91, 378 Flags: No flags set Destination: 66 Annotation: Subtype: Link Rect: 88, 355, 90, 362 Flags: No flags set Destination: 66 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 86, 728, 97, 736 Flags: No flags set Annotation: Subtype: Link Rect: 97, 728, 240, 736 Flags: No flags set Annotation: Subtype: Link Rect: 93, 715, 104, 723 Flags: No flags set Annotation: Subtype: Link Rect: 104, 715, 247, 723 Flags: No flags set Annotation: Subtype: Link Rect: 139, 702, 150, 710 Flags: No flags set Annotation: Subtype: Link Rect: 150, 702, 274, 710 Flags: No flags set Annotation: Subtype: Link Rect: 45, 689, 64, 697 Flags: No flags set Annotation: Subtype: Link Rect: 130, 676, 141, 684 Flags: No flags set Annotation: Subtype: Link Rect: 141, 676, 283, 684 Flags: No flags set Annotation: Subtype: Link Rect: 89, 663, 100, 671 Flags: No flags set Annotation: Subtype: Link Rect: 100, 663, 243, 671 Flags: No flags set Annotation: Subtype: Link Rect: 94, 650, 105, 658 Flags: No flags set Annotation: Subtype: Link Rect: 105, 650, 248, 658 Flags: No flags set Annotation: Subtype: Link Rect: 125, 637, 136, 645 Flags: No flags set Annotation: Subtype: Link Rect: 136, 637, 279, 645 Flags: No flags set Annotation: Subtype: Link Rect: 89, 624, 101, 632 Flags: No flags set Annotation: Subtype: Link Rect: 101, 624, 243, 632 Flags: No flags set Annotation: Subtype: Link Rect: 104, 612, 115, 620 Flags: No flags set Annotation: Subtype: Link Rect: 115, 612, 257, 620 Flags: No flags set Annotation: Subtype: Link Rect: 96, 599, 107, 607 Flags: No flags set Annotation: Subtype: Link Rect: 107, 599, 250, 607 Flags: No flags set Annotation: Subtype: Link Rect: 84, 586, 95, 594 Flags: No flags set Annotation: Subtype: Link Rect: 95, 586, 238, 594 Flags: No flags set Annotation: Subtype: Link Rect: 84, 573, 95, 581 Flags: No flags set Annotation: Subtype: Link Rect: 95, 573, 238, 581 Flags: No flags set Annotation: Subtype: Link Rect: 178, 325, 288, 333 Flags: No flags set Annotation: Subtype: Link Rect: 63, 315, 288, 322 Flags: No flags set Annotation: Subtype: Link Rect: 63, 304, 183, 312 Flags: No flags set Annotation: Subtype: Link Rect: 160, 283, 288, 291 Flags: No flags set Annotation: Subtype: Link Rect: 63, 273, 273, 280 Flags: No flags set Annotation: Subtype: Link Rect: 108, 231, 231, 239 Flags: No flags set Annotation: Subtype: Link Rect: 155, 210, 288, 218 Flags: No flags set Annotation: Subtype: Link Rect: 63, 200, 287, 207 Flags: No flags set Annotation: Subtype: Link Rect: 63, 189, 102, 197 Flags: No flags set Annotation: Subtype: Link Rect: 447, 163, 533, 171 Flags: No flags set Annotation: Subtype: Link Rect: 319, 150, 361, 158 Flags: No flags set Annotation: Subtype: Link Rect: 86, 730, 94, 739 Flags: No flags set Annotation: Subtype: Link Rect: 93, 717, 101, 726 Flags: No flags set Annotation: Subtype: Link Rect: 139, 704, 147, 713 Flags: No flags set Annotation: Subtype: Link Rect: 130, 678, 138, 687 Flags: No flags set Annotation: Subtype: Link Rect: 89, 665, 97, 674 Flags: No flags set Annotation: Subtype: Link Rect: 94, 652, 103, 661 Flags: No flags set Annotation: Subtype: Link Rect: 125, 639, 134, 648 Flags: No flags set Annotation: Subtype: Link Rect: 89, 626, 98, 635 Flags: No flags set Annotation: Subtype: Link Rect: 104, 614, 112, 622 Flags: No flags set Annotation: Subtype: Link Rect: 96, 601, 105, 609 Flags: No flags set Annotation: Subtype: Link Rect: 84, 588, 92, 596 Flags: No flags set Annotation: Subtype: Link Rect: 84, 575, 92, 583 Flags: No flags set Checksum: 33a920cf Type: CRC32 Checksum: e8e048ac83f45cbeaeba4bbced5f79df Type: MD5 Checksum: a3ab52a593c4afc536a43329f06663e1835873cf Type: SHA-1