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RYHJYL+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 224 0 IVQPXD+NewBaskerville-Italic Type 1C WinAnsi yes yes yes 231 0 HWBJJF+HelveticaNeueLTStd-It Type 1C Custom yes yes yes 234 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-22 02:48:25 CET RepresentationInformation: pmc_34389618.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-09-06 03:37:13 CEST Size: 3652595 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 400 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: First-­in-­human phase I/Ib open-­label dose-­escalation study of GWN323 (anti-­GITR) as a single agent and in combination with spartalizumab (anti-­PD-1) in patients with advanced solid tumors and lymphomas Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Patient population Children: Item: Title: Inclusion criteria Item: Title: Exclusion criteria Item: Title: Study design and treatment Item: Title: MTD determination Item: Title: Safety and efficacy assessments Item: Title: Pharmacokinetic assessments Item: Title: Biomarker and PD assessments Item: Title: Statistical analyses Item: Title: Results Children: Item: Title: Patient characteristics Item: Title: Treatment exposure Item: Title: MTD and maximum administered dose (MAD) Item: Title: Safety Item: Title: Efficacy Item: Title: Pharmacokinetics Item: Title: Biomarkers Item: Title: Discussion Item: Title: Conclusions Item: Title: References Info: Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 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