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Keywords: white matter hyper intensity, stroke, brain health, brain vulnerability, post-stroke outcomes, functional independence, functional outcome after acute stroke, acute ischemic stroke Author: Sungmin Hong Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Sep 8 09:34:45 2021 CEST ModDate: Wed Sep 8 09:57:54 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 694995 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BSKNWD+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 34 0 LIDRJE+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 47 0 IWTNVY+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 49 0 ZPIYSU+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 54 0 NDEJJL+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 29 0 ALOQSF+MTSY Type 1C Custom yes yes no 62 0 IMQECW+RMTMI Type 1C Custom yes yes no 64 0 WMTPNJ+MinionPro-Regular Type 1C Custom yes yes no 66 0 HMKFTM+MinionPro-Bold Type 1C Custom yes yes no 100 0 ATWMAW+MinionPro-It Type 1C Custom yes yes no 111 0 UADLTO+MTSYB Type 1C Custom yes yes no 127 0 QASLBY+MTGU Type 1C Custom yes yes no 218 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:39:31 CEST RepresentationInformation: pmc_34566844.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:05:44 CEST Size: 694995 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 256 FreeObjects: 15 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Methods Destination: section*.3 Children: Item: Title: Standard Protocol Approvals, Registrations, and Patient Consents Destination: section*.4 Item: Title: Data, Clinical Characteristics, and WMH Quantification Destination: section*.5 Item: Title: Unaccounted WMH Burden Destination: section*.6 Item: Title: Results Destination: section*.7 Children: Item: Title: Population Analysis Destination: section*.8 Item: Title: Acute Stroke Severity Subgroup Analysis Destination: section*.9 Item: Title: Discussion Destination: section*.10 Item: Title: Conclusion Destination: section*.11 Item: Title: Data Availability Statement Destination: section*.12 Item: Title: MRI-GENIE, GISCOME and International Stroke Genetics Consortium Destination: section*.13 Item: Title: Author Contributions Destination: section*.14 Item: Title: Funding Destination: section*.15 Item: Title: Supplementary Material Destination: section*.16 Item: Title: References Destination: section*.17 Info: Title: Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke Author: Sungmin Hong Subject: Objective: To personalize the[153mm][-67mm]Q10 prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. 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