a6a1ab6d74c05a1c6c6c8848763d9497 pmc_34630277.pdf 0fd87787f6c6d6e38d391d2aedcd1e5e819b9166 pmc_34630277.pdf 5823df048e0e17416e7e327377d8ab20d892af3048a2eec7397d02131a83e69a pmc_34630277.pdf Title: Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice Subject: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the neuromuscular system for which currently there is no effective therapy. Keywords: amyotrophic lateral sclerosis, neuregulin 1, ErbB receptors, motoneuron, neuromuscular junction, spinal cord Author: Xavier Navarro Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Sep 16 09:25:14 2021 CEST ModDate: Thu Sep 16 12:22:45 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 4669967 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RZAHTN+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 37 0 NMEQAM+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 42 0 MISMEX+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 55 0 RAXXAX+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 57 0 PXKZJI+HelveticaNeueLTStd-Roman Type 1C WinAnsi yes yes no 61 0 RZLEHD+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 64 0 MIANFT+MinionPro-Regular Type 1C Custom yes yes no 66 0 IZKOHP+MTSY Type 1C Custom yes yes yes 115 0 PEHVQC+MinionPro-It Type 1C WinAnsi yes yes no 117 0 BCOYDD+MinionPro-Bold Type 1C Custom yes yes no 120 0 IOLGNI+MTGU Type 1C Custom yes yes no 136 0 GBAUGV+RMTMI Type 1C WinAnsi yes yes no 160 0 MAFHMF+CMR5 Type 1C WinAnsi yes yes no 202 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 02:56:25 CEST RepresentationInformation: pmc_34630277.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:05:49 CEST Size: 4669967 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 375 FreeObjects: 17 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in t栀攀 匀伀䐀㄀䜀㤀㌀䄀 䄀䰀匀 䴀椀挀攩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㈹‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㔯䅣瑩潮⽇潔漯偲敶′㠠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Animals and Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Virus Production and Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Electrophysiological Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Locomotion Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Nucleic Acids Extraction and Real Time PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Histological Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Immunoblot Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: NRG1-I and NRG1-III Overexpression in Skeletal Muscles and Spinal Cord Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Combined NRG1 Gene Therapy Preserves Motor Function in SOD1G93A Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Combined Gene Therapy Preserves the Number of MN and Reduces Glial Reactivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: NRG1 Type I and Type III Isoforms Signaling Pathways Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Combined NRG1 Gene Therapy Does Not Produce a Synergic Effect on Neuromuscular Function in SOD1G93A Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Info: Title: Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice Author: Xavier Navarro Subject: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the neuromuscular system for which currently there is no effective therapy. Keywords: amyotrophic lateral sclerosis, neuregulin 1, ErbB receptors, motoneuron, neuromuscular junction, spinal cord Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Sep 16 09:55:14 CEST 2021 ModDate: Thu Sep 16 12:52:45 CEST 2021 ID: 0xab75e32d85a995ab16111d0c621fb26b, 0x75b86af10dbb904c908cfbe81d9f0083 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3600 ImageHeight: 3990 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 5100 ImageHeight: 4017 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 2146 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1303 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1503 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: RZLEHD+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: RZLEHD+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -133, -205, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBAUGV+RMTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: GBAUGV+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 682, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MIANFT+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: MIANFT+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RZAHTN+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: RZAHTN+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -19, -214, 848, 786 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IOLGNI+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: IOLGNI+MTGU Flags: Symbolic FontBBox: 0, -188, 607, 460 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NMEQAM+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 242 FontDescriptor: FontName: NMEQAM+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MAFHMF+CMR5 FontSubset: true FirstChar: 35 LastChar: 36 FontDescriptor: FontName: MAFHMF+CMR5 Flags: Nonsymbolic, AllCap FontBBox: 0, -194, 999, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IZKOHP+MTSY FontSubset: true FirstChar: 2 LastChar: 68 FontDescriptor: FontName: IZKOHP+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PEHVQC+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: PEHVQC+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MISMEX+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 135 FontDescriptor: FontName: MISMEX+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BCOYDD+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: BCOYDD+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 860, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RAXXAX+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 243 FontDescriptor: FontName: RAXXAX+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PXKZJI+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 51 LastChar: 71 FontDescriptor: FontName: PXKZJI+HelveticaNeueLTStd-Roman Flags: Nonsymbolic, AllCap FontBBox: 0, -17, 697, 731 FontFile3: true Encoding: WinAnsiEncoding XMP: 2021-09-16T12:55:14+05:30 LaTeX with hyperref package + hypdvips 2021-09-16T15:52:45+05:30 2021-09-16T15:52:45+05:30 application/pdf Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the neuromuscular system for which currently there is no effective therapy. Xavier Navarro Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice amyotrophic lateral sclerosis neuregulin 1 ErbB receptors motoneuron neuromuscular junction spinal cord amyotrophic lateral sclerosis, neuregulin 1, ErbB receptors, motoneuron, neuromuscular junction, spinal cord dvips + MiKTeX GPL Ghostscript 9.0 uuid:84a31664-5c13-4214-91c7-b1e216147b37 uuid:e08c77c3-7b0b-4af8-9921-b19a574fd9ac Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 144, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 456, 728, 498, 736 Annotation: Subtype: Link Rect: 498, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 111, 38 Annotation: Subtype: Link Rect: 114, 30, 174, 38 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 530, 160, 540 Annotation: Subtype: Link Rect: 89, 394, 160, 401 Annotation: Subtype: Link Rect: 74, 72, 160, 79 Annotation: Subtype: Link Rect: 176, 544, 551, 654 Annotation: Subtype: Link Rect: 336, 95, 342, 106 Destination: External Annotation: Subtype: Link Rect: 345, 95, 352, 106 Destination: External Annotation: Subtype: Link Rect: 284, 72, 290, 83 Destination: External Annotation: Subtype: Link Rect: 453, 72, 460, 83 Destination: External Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 47, 697, 53, 708 Destination: External Annotation: Subtype: Link Rect: 56, 697, 62, 708 Destination: External Annotation: Subtype: Link Rect: 216, 697, 223, 708 Destination: External Annotation: Subtype: Link Rect: 226, 697, 232, 708 Destination: External Annotation: Subtype: Link Rect: 47, 685, 58, 697 Destination: External Annotation: Subtype: Link Rect: 138, 662, 144, 674 Destination: External Annotation: Subtype: Link Rect: 215, 640, 226, 651 Destination: External Annotation: Subtype: Link Rect: 220, 605, 231, 617 Destination: External Annotation: Subtype: Link Rect: 121, 571, 132, 582 Destination: External Annotation: Subtype: Link Rect: 135, 571, 146, 582 Destination: External Annotation: Subtype: Link Rect: 179, 548, 190, 559 Destination: External Annotation: Subtype: Link Rect: 193, 548, 204, 559 Destination: External Annotation: Subtype: Link Rect: 207, 536, 218, 548 Destination: External Annotation: Subtype: Link Rect: 214, 491, 225, 502 Destination: External Annotation: Subtype: Link Rect: 228, 491, 239, 502 Destination: External Annotation: Subtype: Link Rect: 47, 456, 58, 468 Destination: External Annotation: Subtype: Link Rect: 61, 456, 72, 468 Destination: External Annotation: Subtype: Link Rect: 75, 456, 86, 468 Destination: External Annotation: Subtype: Link Rect: 182, 433, 193, 445 Destination: External Annotation: Subtype: Link Rect: 85, 399, 97, 410 Destination: External Annotation: Subtype: Link Rect: 177, 330, 184, 342 Destination: External Annotation: Subtype: Link Rect: 191, 330, 202, 342 Destination: External Annotation: Subtype: Link Rect: 208, 330, 220, 342 Destination: External Annotation: Subtype: Link Rect: 274, 307, 285, 319 Destination: External Annotation: Subtype: Link Rect: 89, 239, 100, 250 Destination: External Annotation: Subtype: Link Rect: 118, 193, 129, 204 Destination: External Annotation: Subtype: Link Rect: 132, 193, 143, 204 Destination: External Annotation: Subtype: Link Rect: 218, 170, 229, 181 Destination: External Annotation: Subtype: Link Rect: 232, 170, 243, 181 Destination: External Annotation: Subtype: Link Rect: 183, 135, 194, 147 Destination: External Annotation: Subtype: Link Rect: 67, 90, 78, 101 Destination: External Annotation: Subtype: Link Rect: 81, 90, 92, 101 Destination: External Annotation: Subtype: Link Rect: 382, 708, 393, 720 Destination: External Annotation: Subtype: Link Rect: 363, 685, 374, 697 Destination: External Annotation: Subtype: Link Rect: 480, 685, 491, 697 Destination: External Annotation: Subtype: Link Rect: 365, 674, 376, 685 Destination: External Annotation: Subtype: Link Rect: 329, 640, 340, 651 Destination: External Annotation: Subtype: Link Rect: 379, 225, 476, 235 Destination: External Annotation: Subtype: Link Rect: 520, 193, 531, 204 Destination: External Annotation: Subtype: Link Rect: 534, 193, 546, 204 Destination: External Annotation: Subtype: Link Rect: 510, 67, 521, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 181, 697, 192, 708 Destination: External Annotation: Subtype: Link Rect: 130, 683, 229, 694 Annotation: Subtype: Link Rect: 245, 662, 256, 674 Destination: External Annotation: Subtype: Link Rect: 258, 662, 269, 674 Destination: External Annotation: Subtype: Link Rect: 128, 548, 139, 559 Destination: External Annotation: Subtype: Link Rect: 85, 491, 96, 503 Destination: External Annotation: Subtype: Link Rect: 99, 491, 110, 503 Destination: External Annotation: Subtype: Link Rect: 258, 434, 269, 446 Destination: External Annotation: Subtype: Link Rect: 274, 434, 285, 446 Destination: External Annotation: Subtype: Link Rect: 171, 400, 182, 411 Destination: External Annotation: Subtype: Link Rect: 184, 400, 195, 411 Destination: External Annotation: Subtype: Link Rect: 254, 343, 265, 355 Destination: External Annotation: Subtype: Link Rect: 429, 697, 440, 708 Destination: External Annotation: Subtype: Link Rect: 343, 479, 354, 491 Destination: External Annotation: Subtype: Link Rect: 520, 261, 531, 273 Destination: External Annotation: Subtype: Link Rect: 534, 261, 546, 273 Destination: External Annotation: Subtype: Link Rect: 507, 158, 518, 170 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 261, 602, 272, 613 Destination: External Annotation: Subtype: Link Rect: 274, 602, 285, 613 Destination: External Annotation: Subtype: Link Rect: 244, 508, 285, 518 Destination: External Annotation: Subtype: Link Rect: 47, 474, 87, 484 Destination: External Annotation: Subtype: Link Rect: 140, 439, 194, 450 Destination: External Annotation: Subtype: Link Rect: 141, 359, 238, 370 Destination: External Annotation: Subtype: Link Rect: 47, 276, 102, 286 Destination: External Annotation: Subtype: Link Rect: 62, 242, 117, 252 Destination: External Annotation: Subtype: Link Rect: 184, 207, 240, 218 Destination: External Annotation: Subtype: Link Rect: 47, 161, 88, 172 Destination: External Annotation: Subtype: Link Rect: 475, 695, 528, 705 Destination: External Annotation: Subtype: Link Rect: 307, 626, 361, 636 Destination: External Annotation: Subtype: Link Rect: 409, 531, 450, 542 Destination: External Annotation: Subtype: Link Rect: 451, 511, 462, 522 Destination: External Annotation: Subtype: Link Rect: 464, 511, 475, 522 Destination: External Annotation: Subtype: Link Rect: 402, 463, 455, 473 Destination: External Annotation: Subtype: Link Rect: 400, 379, 411, 391 Destination: External Annotation: Subtype: Link Rect: 460, 379, 471, 391 Destination: External Annotation: Subtype: Link Rect: 421, 331, 477, 342 Destination: External Annotation: Subtype: Link Rect: 307, 297, 358, 307 Destination: External Annotation: Subtype: Link Rect: 389, 263, 450, 273 Destination: External Annotation: Subtype: Link Rect: 323, 217, 363, 227 Destination: External Annotation: Subtype: Link Rect: 335, 185, 346, 196 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 107, 169, 118, 181 Destination: External Annotation: Subtype: Link Rect: 230, 158, 241, 169 Destination: External Annotation: Subtype: Link Rect: 246, 158, 257, 169 Destination: External Annotation: Subtype: Link Rect: 186, 124, 197, 135 Destination: External Annotation: Subtype: Link Rect: 201, 124, 212, 135 Destination: External Annotation: Subtype: Link Rect: 217, 124, 228, 135 Destination: External Annotation: Subtype: Link Rect: 227, 89, 238, 101 Destination: External Annotation: Subtype: Link Rect: 373, 204, 384, 215 Destination: External Annotation: Subtype: Link Rect: 454, 169, 465, 181 Destination: External Annotation: Subtype: Link Rect: 468, 169, 479, 181 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 77, 79, 89, 91 Destination: External Annotation: Subtype: Link Rect: 482, 79, 493, 91 Destination: External Annotation: Subtype: Link Rect: 496, 79, 507, 91 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 274, 182, 285, 194 Destination: External Annotation: Subtype: Link Rect: 184, 113, 195, 125 Destination: External Annotation: Subtype: Link Rect: 431, 182, 442, 194 Destination: External Annotation: Subtype: Link Rect: 360, 159, 371, 171 Destination: External Annotation: Subtype: Link Rect: 375, 159, 386, 171 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 47, 113, 58, 125 Destination: External Annotation: Subtype: Link Rect: 62, 113, 73, 125 Destination: External Annotation: Subtype: Link Rect: 231, 68, 242, 79 Destination: External Annotation: Subtype: Link Rect: 245, 68, 256, 79 Destination: External Annotation: Subtype: Link Rect: 534, 159, 546, 171 Destination: External Annotation: Subtype: Link Rect: 401, 136, 412, 148 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 96, 639, 194, 649 Destination: External Annotation: Subtype: Link Rect: 552, 534, 303, 558 Annotation: Subtype: Link Rect: 428, 493, 504, 502 Annotation: Subtype: Link Rect: 397, 440, 431, 448 Destination: External Annotation: Subtype: Link Rect: 191, 321, 257, 328 Annotation: Subtype: Link Rect: 70, 291, 138, 300 Annotation: Subtype: Link Rect: 81, 263, 172, 272 Annotation: Subtype: Link Rect: 70, 217, 170, 224 Annotation: Subtype: Link Rect: 292, 178, 56, 197 Annotation: Subtype: Link Rect: 292, 129, 56, 150 Annotation: Subtype: Link Rect: 70, 92, 161, 101 Annotation: Subtype: Link Rect: 243, 64, 291, 73 Annotation: Subtype: Link Rect: 365, 331, 423, 338 Annotation: Subtype: Link Rect: 331, 293, 416, 300 Annotation: Subtype: Link Rect: 331, 263, 431, 272 Annotation: Subtype: Link Rect: 440, 245, 493, 253 Annotation: Subtype: Link Rect: 402, 215, 460, 225 Annotation: Subtype: Link Rect: 331, 189, 409, 196 Annotation: Subtype: Link Rect: 331, 151, 419, 158 Annotation: Subtype: Link Rect: 382, 122, 467, 130 Annotation: Subtype: Link Rect: 443, 92, 542, 102 Annotation: Subtype: Link Rect: 372, 64, 460, 73 Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 412, 28, 551, 37 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 70, 680, 149, 687 Annotation: Subtype: Link Rect: 70, 642, 146, 649 Annotation: Subtype: Link Rect: 101, 602, 169, 611 Annotation: Subtype: Link Rect: 70, 576, 163, 583 Annotation: Subtype: Link Rect: 70, 536, 136, 545 Annotation: Subtype: Link Rect: 70, 509, 123, 517 Annotation: Subtype: Link Rect: 292, 478, 56, 499 Annotation: Subtype: Link Rect: 292, 442, 56, 461 Annotation: Subtype: Link Rect: 169, 424, 229, 431 Annotation: Subtype: Link Rect: 108, 405, 200, 413 Annotation: Subtype: Link Rect: 146, 375, 222, 384 Annotation: Subtype: Link Rect: 70, 339, 161, 346 Annotation: Subtype: Link Rect: 70, 301, 139, 309 Annotation: Subtype: Link Rect: 70, 262, 170, 271 Annotation: Subtype: Link Rect: 126, 235, 202, 242 Annotation: Subtype: Link Rect: 179, 214, 262, 224 Annotation: Subtype: Link Rect: 126, 176, 184, 186 Annotation: Subtype: Link Rect: 70, 150, 128, 157 Annotation: Subtype: Link Rect: 157, 110, 222, 119 Annotation: Subtype: Link Rect: 70, 72, 152, 82 Annotation: Subtype: Link Rect: 331, 689, 432, 697 Annotation: Subtype: Link Rect: 331, 651, 419, 659 Annotation: Subtype: Link Rect: 412, 623, 464, 630 Annotation: Subtype: Link Rect: 432, 583, 513, 593 Annotation: Subtype: Link Rect: 452, 546, 534, 555 Annotation: Subtype: Link Rect: 331, 508, 397, 517 Annotation: Subtype: Link Rect: 331, 470, 400, 479 Annotation: Subtype: Link Rect: 354, 434, 418, 441 Annotation: Subtype: Link Rect: 458, 415, 523, 422 Annotation: Subtype: Link Rect: 552, 366, 316, 385 Annotation: Subtype: Link Rect: 552, 327, 316, 348 Annotation: Subtype: Link Rect: 552, 280, 316, 300 Annotation: Subtype: Link Rect: 552, 234, 316, 253 Annotation: Subtype: Link Rect: 354, 197, 432, 205 Annotation: Subtype: Link Rect: 476, 169, 530, 176 Annotation: Subtype: Link Rect: 410, 131, 482, 138 Annotation: Subtype: Link Rect: 431, 93, 506, 100 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 70, 697, 178, 706 Annotation: Subtype: Link Rect: 104, 661, 178, 668 Annotation: Subtype: Link Rect: 85, 621, 172, 630 Annotation: Subtype: Link Rect: 164, 583, 258, 593 Annotation: Subtype: Link Rect: 70, 546, 151, 555 Annotation: Subtype: Link Rect: 455, 593, 481, 600 Annotation: Subtype: Link Rect: 482, 593, 514, 600 Annotation: Subtype: Link Rect: 515, 593, 551, 600 Annotation: Subtype: Link Rect: 304, 583, 327, 590 Annotation: Subtype: Link Rect: 327, 582, 354, 591 Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 412, 29, 551, 38 Checksum: 3c93d2ee Type: CRC32 Checksum: a6a1ab6d74c05a1c6c6c8848763d9497 Type: MD5 Checksum: 0fd87787f6c6d6e38d391d2aedcd1e5e819b9166 Type: SHA-1