94ed1e1df815782f0f28541f2d4f8c07 pmc_34640420.pdf a6d6856963fbfd8d756845cfbb1189170803c717 pmc_34640420.pdf c43a02d0c06939fa92dc81c071efe815b5b568e3d1ba8b2acbcc2772619217fb pmc_34640420.pdf Title: Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome Subject: Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged 70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 5.75 vs. 78.45 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men(p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. Keywords: elderly; non-ST-segment elevation acute coronary syndromes; women; diabetes mellitus Author: Pablo Díez-Villanueva, Jose María García-Acuña, Sergio Raposeiras-Roubin, Jose A. Barrabés, Alberto Cordero, Manuel Martínez-Sellés, Alfredo Bardají, Francisco Marín, Juan M. Ruiz-Nodar, Nuria Vicente-Ibarra, Gonzalo L. Alonso Salinas, Belén Cid-Alvárez, Emad Abu Assi, Frances Formiga, Julio Núñez, Eduardo Núñez, Albert Ariza-Solé and Juan Sanchis Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Sep 26 11:35:38 2021 CEST ModDate: Sun Sep 26 11:46:25 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 645191 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YQOTQA+VnURWPalladioL Type 1 Custom yes yes no 10 0 XLXQQI+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 XPEGTO+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 EQCEEV+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 JGMOZW+CMSY10 Type 1 Builtin yes yes no 28 0 OSMCID+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 88 0 OLDJAM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 107 0 OLDJAO+PalatinoLinotype TrueType WinAnsi yes yes no 110 0 OLDJBA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 113 0 OLDJAM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 192 0 OLDJAO+PalatinoLinotype TrueType WinAnsi yes yes no 195 0 OLDJBA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 198 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:38:56 CEST RepresentationInformation: pmc_34640420.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:05:52 CEST Size: 645191 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 427 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Study Population Destination: subsection.2.1 Item: Title: End Point Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Ethics Destination: subsection.2.4 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome Author: Pablo Díez-Villanueva, Jose María García-Acuña, Sergio Raposeiras-Roubin, Jose A. Barrabés, Alberto Cordero, Manuel Martínez-Sellés, Alfredo Bardají, Francisco Marín, Juan M. Ruiz-Nodar, Nuria Vicente-Ibarra, Gonzalo L. Alonso Salinas, Belén Cid-Alvárez, Emad Abu Assi, Frances Formiga, Julio Núñez, Eduardo Núñez, Albert Ariza-Solé and Juan Sanchis Subject: Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged 70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 5.75 vs. 78.45 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men(p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18 1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84 1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. 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