caf6ca8d80285005e082d9593e1b341e pmc_34683180.pdf 8826b2ca22974f63df382317cc533aca87a804b5 pmc_34683180.pdf 5cf56f226fec96c9393eb3df7e493b41497e47ffa75b4332088e70c1728dae98 pmc_34683180.pdf Title: A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study Subject: Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805–0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. Keywords: obesity; bariatric surgery; weight loss; genetics; polygenic risk Author: Andreea Ciudin, Enzamaría Fidilio, Liliana Gutiérrez-Carrasquilla, Assumpta Caixàs, Núria Vilarrasa, Silvia Pellitero, Andreu Simó-Servat, Ramon Vilallonga, Amador Ruiz, Maricruz de la Fuente, Alexis Luna, Enric Sánchez, Mercedes Rigla, Cristina Hernández, Eduardo Salas, Rafael Simó and Albert Lecube Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Oct 18 09:35:03 2021 CEST ModDate: Mon Oct 18 09:44:30 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 721769 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UQZHSH+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 KORLVE+VnURWPalladioL Type 1 Custom yes yes no 15 0 FTBGON+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 ABWVGL+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 NAGZWV+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 UIJACC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 TWBWZR+CMSY10 Type 1 Builtin yes yes no 81 0 PHKEMC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 95 0 PHKEMD+PalatinoLinotype CID TrueType Identity-H yes yes yes 98 0 PHKEME+PalatinoLinotype TrueType WinAnsi yes yes no 104 0 PHKEMG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 107 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 121 0 PHKEMC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 131 0 PHKEMD+PalatinoLinotype CID TrueType Identity-H yes yes yes 134 0 PHKEME+PalatinoLinotype TrueType WinAnsi yes yes no 140 0 PHKEMG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 143 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-22 02:39:24 CET RepresentationInformation: pmc_34683180.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-01-10 08:29:59 CET Size: 721769 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 323 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Statement on Ethics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Study Design and Description of the Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Outcome Weight Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Statistical Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Baseline Characteristics of Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Construction of a Clinical Risk Score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Construction of a Genetic Risk Score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Construction of the OBEGEN Clinical-Genetic Risk Score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study Author: Andreea Ciudin, Enzamaría Fidilio, Liliana Gutiérrez-Carrasquilla, Assumpta Caixàs, Núria Vilarrasa, Silvia Pellitero, Andreu Simó-Servat, Ramon Vilallonga, Amador Ruiz, Maricruz de la Fuente, Alexis Luna, Enric Sánchez, Mercedes Rigla, Cristina Hernández, Eduardo Salas, Rafael Simó and Albert Lecube Subject: Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805 0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. 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