f5590a744389cd0dd3de2fac47052563 pmc_34684012.pdf 893c0b51d43f9ac62a8983c475bab747d90a22cd pmc_34684012.pdf 5186638cff1af90d249817c9b594ee7dfeabc93469bdcb0c4fbc7d18e28ac847 pmc_34684012.pdf Title: Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications Subject: Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to improve cancer therapy. Several research works have highlighted the synthesis of gold and silver nanoparticles by green chemistry, using biological entities to minimize the use of solvents and control their physicochemical and biological properties. Recent advances in evaluating the anticancer effect of green biogenic Au and Ag nanoparticles are mainly focused on the use of conventional 2D cell culture and in vivo murine models that allow determination of the half-maximal inhibitory concentration, a critical parameter to move forward clinical trials. However, the interaction between nanoparticles and the tumor microenvironment is not yet fully understood. Therefore, it is necessary to develop more human-like evaluation models or to improve the existing ones for a better understanding of the molecular bases of cancer. This review provides recent advances in biosynthesized Au and Ag nanoparticles for seven of the most common and relevant cancers and their biological assessment. In addition, it provides a general idea of the in silico, in vitro, ex vivo, and in vivo models used for the anticancer evaluation of green biogenic metal-based nanoparticles. Keywords: nanomaterials; metal-based nanoparticles; biosynthesis; cancer treatment; in silico; in vitro; ex vivo; in vivo Author: Ernesto Tinajero-Díaz, Daniela Salado-Leza, Carmen Gonzalez, Moisés Martínez Velázquez, Zaira López, Jorge Bravo-Madrigal, Peter Knauth, Flor Y. Flores-Hernández, Sara Elisa Herrera-Rodríguez, Rosa E. Navarro, Alejandro Cabrera-Wrooman, Edgar Krötzsch, Zaira Y. García Carvajal and Rodolfo Hernández-Gutiérrez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Oct 18 10:50:16 2021 CEST ModDate: Mon Oct 18 11:04:58 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 52 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4508563 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ARNGBH+VnURWPalladioL Type 1 Custom yes yes no 10 0 XWSANO+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 PVZZYL+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 QFFWMD+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 IAFAOG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 37 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 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Geometrical Aspects to Functionality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Green Biosynthesis of MNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Phytochemical Synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Microorganism-Assisted Synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Development of Stimuli-Responsive MNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Thermo-Responsive Polymers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: pH-Responsive Mechanisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Light-Responsive Groups Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Magnetic Targeting and Theragnostic Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: The Influence of the Physicochemical Properties of MNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Cancer Evaluation Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Children: Item: Title: In Silico Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Conventional 2D In Vitro Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Mimetic 3D Cell Culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Ex Vivo Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: Isolated Tissue System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Isolated and Perfused Organ System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Integrative Evidence about the Physiological Profile of AgNPs and AuNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: In Vivo Evaluation Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: C. elegans and D. rerio (Zebrafish) Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Murine Model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Application of Biosynthetic MNPs in Cancer Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Skin Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Breast Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Lung Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Prostate Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Colorectal Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Cervical Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Leukemia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Info: Title: Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications Author: Ernesto Tinajero-Díaz, Daniela Salado-Leza, Carmen Gonzalez, Moisés Martínez Velázquez, Zaira López, Jorge Bravo-Madrigal, Peter Knauth, Flor Y. Flores-Hernández, Sara Elisa Herrera-Rodríguez, Rosa E. Navarro, Alejandro Cabrera-Wrooman, Edgar Krötzsch, Zaira Y. García Carvajal and Rodolfo Hernández-Gutiérrez Subject: Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to improve cancer therapy. Several research works have highlighted the synthesis of gold and silver nanoparticles by green chemistry, using biological entities to minimize the use of solvents and control their physicochemical and biological properties. Recent advances in evaluating the anticancer effect of green biogenic Au and Ag nanoparticles are mainly focused on the use of conventional 2D cell culture and in vivo murine models that allow determination of the half-maximal inhibitory concentration, a critical parameter to move forward clinical trials. However, the interaction between nanoparticles and the tumor microenvironment is not yet fully understood. Therefore, it is necessary to develop more human-like evaluation models or to improve the existing ones for a better understanding of the molecular bases of cancer. This review provides recent advances in biosynthesized Au and Ag nanoparticles for seven of the most common and relevant cancers and their biological assessment. In addition, it provides a general idea of the in silico, in vitro, ex vivo, and in vivo models used for the anticancer evaluation of green biogenic metal-based nanoparticles. 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