8f1e9a0d973a08965612f1c4ed71036a pmc_34707508.pdf 9397cab1be7a0cb6498b5d79542a93d380a7499a pmc_34707508.pdf 70cf742980bbc588608f31e1a9f3b9f64816bbeae02bed63c1e0ea178f5ef421 pmc_34707508.pdf Title: Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction Subject: Objective: To determine the effect of marathon running on serum levels of inflammatory, high energy, and cartilage matrix biomarkers and to ascertain whether these biomarkers levels correlate. Keywords: biomarker, marathon runners, articular cartilage, PIINP, C2C, hyaluronic acid Author: José A. Hernández-Hermoso Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Oct 5 10:03:37 2021 CEST ModDate: Tue Oct 5 18:06:33 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1230592 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ADENMH+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 35 0 JQOBEB+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 48 0 CQUCAK+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 50 0 ISYMUK+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 57 0 GBAUGV+RMTMI Type 1C WinAnsi yes yes no 59 0 YNSYHQ+MTSY Type 1C Custom yes yes yes 61 0 ZIBJYX+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 30 0 SIEMOH+MinionPro-Regular Type 1C Custom yes yes no 69 0 LZFSCL+MinionPro-It Type 1C Custom yes yes no 164 0 AJJMIT+MinionPro-Bold Type 1C Custom yes yes no 167 0 BOCDML+MTGU Type 1C Custom yes yes no 428 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-23 05:26:55 CET RepresentationInformation: pmc_34707508.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:06:02 CEST Size: 1230592 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 500 FreeObjects: 19 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Materials and Methods Destination: section*.3 Children: Item: Title: Measurements of Inflammatory and High-Energy Enzymes Biomarkers Destination: section*.4 Item: Title: Measurements of Non-collagenous and Type II Collagenous Cartilage Biomarkers Destination: section*.5 Item: Title: Statistical Analysis Destination: section*.6 Item: Title: Results Destination: section*.7 Children: Item: Title: Inflammatory and High-Energy Enzymes Biomarkers Destination: section*.8 Item: Title: Non-collagenous Cartilage Biomarkers Destination: section*.9 Item: Title: Type II Collagenous Cartilage Biomarkers Destination: section*.10 Item: Title: Correlation Between Biomarkers Destination: section*.11 Item: Title: Discussion Destination: section*.12 Item: Title: Data Availability Statement Destination: section*.13 Item: Title: Ethics Statement Destination: section*.14 Item: Title: Author Contributions Destination: section*.15 Item: Title: Acknowledgements Destination: section*.16 Item: Title: Supplementary Material Destination: section*.17 Item: Title: References Destination: section*.18 Info: Title: Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction Author: José A. Hernández-Hermoso Subject: Objective: To determine the effect of marathon running on serum levels of inflammatory, high energy, and cartilage matrix biomarkers and to ascertain whether these biomarkers levels correlate. Keywords: biomarker, marathon runners, articular cartilage, PIINP, C2C, hyaluronic acid Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Oct 05 10:33:37 CEST 2021 ModDate: Tue Oct 05 18:36:33 CEST 2021 ID: 0xea932e60135086a51fd677b697ec6602, 0x5dac37b83156cf459fd4fe0f8fbd5e80 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1250 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1206 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1181 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1352 ImageHeight: 2480 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: JQOBEB+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: JQOBEB+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CQUCAK+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 252 FontDescriptor: FontName: CQUCAK+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ADENMH+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 225 FontDescriptor: FontName: ADENMH+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -13, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LZFSCL+MinionPro-It FontSubset: true FirstChar: 3 LastChar: 243 FontDescriptor: FontName: LZFSCL+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SIEMOH+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: SIEMOH+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 821 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AJJMIT+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: AJJMIT+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 724, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ISYMUK+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: ISYMUK+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -70, -205, 826, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GBAUGV+RMTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: GBAUGV+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 682, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BOCDML+MTGU FontSubset: true FirstChar: 98 LastChar: 103 FontDescriptor: FontName: BOCDML+MTGU Flags: Symbolic FontBBox: 0, -206, 504, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YNSYHQ+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: YNSYHQ+MTSY Flags: Symbolic FontBBox: 0, -209, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZIBJYX+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: ZIBJYX+HelveticaNeueLTStd-Bd Flags: Serif, Symbolic FontBBox: -19, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-10-05T13:33:37+05:30 LaTeX with hyperref package + hypdvips 2021-10-05T21:36:33+05:30 2021-10-05T21:36:33+05:30 application/pdf Objective: To determine the effect of marathon running on serum levels of inflammatory, high energy, and cartilage matrix biomarkers and to ascertain whether these biomarkers levels correlate. José A. 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Link Rect: 132, 514, 201, 525 Destination: External Annotation: Subtype: Link Rect: 206, 514, 226, 525 Destination: External Annotation: Subtype: Link Rect: 88, 342, 148, 354 Destination: External Annotation: Subtype: Link Rect: 152, 342, 172, 354 Destination: External Annotation: Subtype: Link Rect: 235, 331, 63, 331 Destination: External Annotation: Subtype: Link Rect: 65, 319, 86, 331 Destination: External Annotation: Subtype: Link Rect: 515, 640, 549, 651 Destination: External Annotation: Subtype: Link Rect: 304, 628, 324, 640 Destination: External Annotation: Subtype: Link Rect: 452, 605, 519, 617 Destination: External Annotation: Subtype: Link Rect: 525, 605, 546, 617 Destination: External Annotation: Subtype: Link Rect: 515, 594, 326, 594 Destination: External Annotation: Subtype: Link Rect: 330, 582, 351, 594 Destination: External Annotation: Subtype: Link Rect: 355, 582, 414, 594 Destination: External Annotation: Subtype: Link Rect: 419, 582, 439, 594 Destination: External Annotation: Subtype: Link Rect: 444, 582, 524, 594 Destination: External Annotation: Subtype: Link Rect: 529, 582, 549, 594 Destination: External Annotation: Subtype: Link Rect: 304, 571, 354, 582 Destination: External Annotation: Subtype: Link Rect: 357, 571, 377, 582 Destination: External Annotation: Subtype: Link Rect: 475, 548, 522, 559 Destination: External Annotation: Subtype: Link Rect: 527, 548, 548, 559 Destination: External Annotation: Subtype: Link Rect: 43, 29, 112, 37 Annotation: Subtype: Link Rect: 116, 29, 176, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 552, 601, 303, 626 Annotation: Subtype: Link Rect: 292, 513, 52, 533 Annotation: Subtype: Link Rect: 292, 466, 52, 485 Annotation: Subtype: Link Rect: 95, 429, 180, 437 Annotation: Subtype: Link Rect: 88, 390, 187, 399 Annotation: Subtype: Link Rect: 95, 352, 176, 361 Annotation: Subtype: Link Rect: 95, 314, 151, 323 Annotation: Subtype: Link Rect: 292, 267, 52, 286 Annotation: Subtype: Link Rect: 292, 218, 52, 239 Annotation: Subtype: Link Rect: 292, 171, 52, 192 Annotation: Subtype: Link Rect: 95, 136, 180, 143 Annotation: Subtype: Link Rect: 292, 88, 52, 107 Annotation: Subtype: Link Rect: 552, 551, 313, 570 Annotation: Subtype: Link Rect: 469, 513, 551, 522 Annotation: Subtype: Link Rect: 469, 475, 550, 484 Annotation: Subtype: Link Rect: 356, 429, 420, 437 Annotation: Subtype: Link Rect: 363, 380, 435, 389 Annotation: Subtype: Link Rect: 348, 352, 456, 361 Annotation: Subtype: Link Rect: 552, 304, 313, 324 Annotation: Subtype: Link Rect: 363, 267, 461, 276 Annotation: Subtype: Link Rect: 363, 221, 448, 228 Annotation: Subtype: Link Rect: 356, 182, 453, 191 Annotation: Subtype: Link Rect: 552, 143, 313, 164 Annotation: Subtype: Link Rect: 356, 107, 411, 115 Annotation: Subtype: Link Rect: 552, 69, 313, 87 Annotation: Subtype: Link Rect: 43, 28, 112, 36 Annotation: Subtype: Link Rect: 116, 28, 176, 36 Annotation: Subtype: Link Rect: 421, 28, 551, 37 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 88, 632, 173, 640 Annotation: Subtype: Link Rect: 95, 593, 176, 602 Annotation: Subtype: Link Rect: 187, 557, 272, 564 Annotation: Subtype: Link Rect: 102, 508, 182, 517 Annotation: Subtype: Link Rect: 217, 479, 273, 488 Annotation: Subtype: Link Rect: 102, 432, 183, 441 Annotation: Subtype: Link Rect: 84, 386, 133, 394 Annotation: Subtype: Link Rect: 84, 347, 154, 356 Annotation: Subtype: Link Rect: 95, 309, 188, 318 Annotation: Subtype: Link Rect: 88, 254, 133, 261 Annotation: Subtype: Link Rect: 88, 214, 169, 223 Annotation: Subtype: Link Rect: 134, 176, 215, 185 Annotation: Subtype: Link Rect: 95, 101, 167, 110 Annotation: Subtype: Link Rect: 374, 697, 454, 706 Annotation: Subtype: Link Rect: 356, 659, 440, 668 Annotation: Subtype: Link Rect: 370, 623, 455, 630 Annotation: Subtype: Link Rect: 552, 573, 313, 593 Annotation: Subtype: Link Rect: 356, 527, 428, 536 Annotation: Subtype: Link Rect: 552, 489, 313, 508 Annotation: Subtype: Link Rect: 372, 451, 448, 460 Annotation: Subtype: Link Rect: 552, 403, 313, 423 Annotation: Subtype: Link Rect: 356, 377, 435, 384 Annotation: Subtype: Link Rect: 341, 339, 426, 346 Annotation: Subtype: Link Rect: 438, 311, 523, 318 Annotation: Subtype: Link Rect: 450, 271, 531, 280 Annotation: Subtype: Link Rect: 447, 243, 515, 252 Annotation: Subtype: Link Rect: 392, 205, 462, 214 Annotation: Subtype: Link Rect: 356, 157, 447, 167 Annotation: Subtype: Link Rect: 479, 140, 545, 148 Annotation: Subtype: Link Rect: 552, 109, 313, 130 Annotation: Subtype: Link Rect: 424, 83, 495, 91 Annotation: Subtype: Link Rect: 43, 29, 112, 37 Annotation: Subtype: Link Rect: 116, 29, 176, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 113, 689, 198, 696 Annotation: Subtype: Link Rect: 524, 661, 551, 668 Annotation: Subtype: Link Rect: 304, 651, 336, 658 Annotation: Subtype: Link Rect: 336, 651, 372, 659 Annotation: Subtype: Link Rect: 373, 651, 396, 658 Annotation: Subtype: Link Rect: 397, 650, 425, 659 Annotation: Subtype: Link Rect: 43, 29, 112, 37 Annotation: Subtype: Link Rect: 116, 29, 176, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Checksum: 8793290a Type: CRC32 Checksum: 8f1e9a0d973a08965612f1c4ed71036a Type: MD5 Checksum: 9397cab1be7a0cb6498b5d79542a93d380a7499a Type: SHA-1 Checksum: 70cf742980bbc588608f31e1a9f3b9f64816bbeae02bed63c1e0ea178f5ef421 Type: SHA-256