e9082310cdce559e6e0e477c967a57b5 pmc_34723243.pdf c2653d733af5a54004015672c2631131a3a1b0ef pmc_34723243.pdf d22c319d6ff8f55ee90c8bae391503b6b4d2c270fd64f2fcadd5c15d786de9a0 pmc_34723243.pdf Title: DCTclock: Clinically-Interpretable and Automated Artificial Intelligence Analysis of Drawing Behavior for Capturing Cognition Subject: Developing tools for efficiently measuring cognitive change specifically and brain health generally—whether for clinical use or as endpoints in clinical trials—is a major challenge, particularly for conditions such as Alzheimer's disease. Keywords: artificial intelligence, cognition, Alzheimer's disease, dementia, DCTclock, clock drawing test, behavior analysis Author: William Souillard-Mandar Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Oct 12 03:38:13 2021 CEST ModDate: Tue Oct 12 05:29:03 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 823706 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IOAQCR+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 34 0 XVNZHV+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 39 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 52 0 HGCGIF+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 54 0 UDGHKZ+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 59 0 ZMQVFX+MinionPro-Regular Type 1C Custom yes yes no 61 0 CUJBNN+MTSY Type 1C Custom yes yes no 97 0 IOFMAH+MinionPro-It Type 1C Custom yes yes no 99 0 SMLTMD+MinionPro-Bold Type 1C Custom yes yes no 104 0 KGCZRL+HelveticaNeueLTStd-Md Type 1C Custom yes yes no 108 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 163 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-22 02:37:34 CET RepresentationInformation: pmc_34723243.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-01-10 08:24:04 CET Size: 823706 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 261 FreeObjects: 15 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: DCTclock: Clinically-Interpretable and Automated Artificial Intelligence Analysis of Drawing Behavior for Capturing Cognition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Compliance With Ethical Regulations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Study Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: DCT Platform Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: DCTclock Algorithm Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Pen Stroke Classification for Drawing Understanding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Drawing Measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Creating Composite Scales and DCTclock Score for Cognitive Impairment Classification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: DCTclock Cut Scores Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Statistical Analysis and Validation Procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Demographics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: DCTclock Metrics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Validation of DCTclock Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Info: Title: DCTclock: Clinically-Interpretable and Automated Artificial Intelligence Analysis of Drawing Behavior for Capturing Cognition Author: William Souillard-Mandar Subject: Developing tools for efficiently measuring cognitive change specifically and brain health generally whether for clinical use or as endpoints in clinical trials is a major challenge, particularly for conditions such as Alzheimer's disease. Keywords: artificial intelligence, cognition, Alzheimer's disease, dementia, DCTclock, clock drawing test, behavior analysis Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Oct 12 04:08:13 CEST 2021 ModDate: Tue Oct 12 05:59:03 CEST 2021 ID: 0x9ee0735642257e5c99f97cbe35ea63fc, 0xe65b5bde8b9e904fb28b286613924b8f Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 745 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 709 ImageHeight: 626 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 785 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: CUJBNN+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: CUJBNN+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IOAQCR+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: IOAQCR+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -9, -214, 925, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IOFMAH+MinionPro-It FontSubset: true FirstChar: 39 LastChar: 169 FontDescriptor: FontName: IOFMAH+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HGCGIF+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 243 FontDescriptor: FontName: HGCGIF+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: XVNZHV+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 151 FontDescriptor: FontName: XVNZHV+HelveticaNeueLTStd-Lt Flags: Serif, Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SMLTMD+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: SMLTMD+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 724, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UDGHKZ+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: UDGHKZ+HelveticaNeueLTStd-MdIt Flags: Nonsymbolic FontBBox: -64, -205, 995, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KGCZRL+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 0 LastChar: 119 FontDescriptor: FontName: KGCZRL+HelveticaNeueLTStd-Md Flags: Symbolic FontBBox: 0, -205, 815, 731 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ZMQVFX+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 234 FontDescriptor: FontName: ZMQVFX+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2021-10-12T07:08:13+05:30 LaTeX with hyperref package + hypdvips 2021-10-12T08:59:03+05:30 2021-10-12T08:59:03+05:30 application/pdf Developing tools for efficiently measuring cognitive change specifically and brain health generally—whether for clinical use or as endpoints in clinical trials—is a major challenge, particularly for conditions such as Alzheimer's disease. 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