addcbac741f51cc70e438e938e443fb4 pmc_34770527.pdf fd2170558b41f358fc15c4f080d52e042dac2f17 pmc_34770527.pdf 9642e23698d25cb951f7ab26e664b9f8e952ccc6adba0c1682270030d24bb5cd pmc_34770527.pdf Title: New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses Subject: Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily placement, as is the case with surface electrodes, the further advancement of PNS paradigms is hampered by the limitation of spatial selectivity due to the current spread and variations of nerve physiology. New electrode designs such as the Transverse Intrafascicular Multichannel Electrode (TIME) were proposed to resolve this issue, but their use was limited by a lack of innovative multichannel stimulation devices. In this study, we introduce a new portable multichannel stimulator—called STIMEP—and implement different stimulation protocols in rats to test its versatility and unveil the potential of its combined use with TIME electrodes in rehabilitation protocols. We developed and tested various stimulation paradigms in a single fascicle and thereafter implanted two TIMEs. We also tested its stimulation using two different waveforms. The results highlighted the versatility of this new stimulation device and advocated for the parameterizing of a hyperpolarizing phase before depolarization as well as the use of small pulse widths when stimulating with multiple electrodes. Keywords: stimulation selectivity; stimulation device; intrafascicular electrode; peripheral nerve; neuroprosthesis Author: Thomas Guiho, Victor Manuel López-Álvarez, Paul Čvančara, Arthur Hiairrassary, David Andreu, Thomas Stieglitz, Xavier Navarro and David Guiraud Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Nov 9 09:35:18 2021 CET ModDate: Tue Nov 9 09:42:05 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 5103697 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UJLLCE+VnURWPalladioL Type 1 Custom yes yes no 10 0 NEGSHV+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 PZGBJM+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 HOWPMU+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 FKUIVJ+CMSY10 Type 1 Builtin yes yes no 28 0 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2023-03-31 12:06:12 CEST Size: 5103697 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 443 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: General Description of the Stimulation Device STIMEP Platform Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: In Vivo Validation of the Stimulation Device and Selectivity Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Experimental Set-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: TIME Implants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Stimulation Paradigms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Signal Processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: STIMEP Successfully Delivered Finely Tuned Stimulations That Potentiate Intrafascicular Stimulation Selectivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: STIMEP Successfully Drove Two TIME Implants Simultaneously and Increased Spatial Selectivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: STIMEP Generated Complex Waveforms and Underlines the Relative Impact of Polarity on Stimulation Selectivity Using TIME Implants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Info: Title: New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses Author: ごとはねちび〠ぇふどとは〬〠ざどっぴはひ〠きちのふづぬ〠がンばづぺ〭チぬぶちひづぺ〬〠ぐちふぬ〠ㅜ晜〰ぶちのㅜ牜〰ちひち〬〠ぁひぴとふひ〠えどちどひひちびびちひべ〬〠いちぶどつ〠ぁのつひづふ〬〠ごとはねちび〠こぴどづでぬどぴぺ〬〠じちぶどづひ〠ぎちぶちひひは〠ちのつ〠いちぶどつ〠ぇふどひちふつ Subject: Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily placement, as is the case with surface electrodes, the further advancement of PNS paradigms is hampered by the limitation of spatial selectivity due to the current spread and variations of nerve physiology. New electrode designs such as the Transverse Intrafascicular Multichannel Electrode (TIME) were proposed to resolve this issue, but their use was limited by a lack of innovative multichannel stimulation devices. In this study, we introduce a new portable multichannel stimulator called STIMEP and implement different stimulation protocols in rats to test its versatility and unveil the potential of its combined use with TIME electrodes in rehabilitation protocols. We developed and tested various stimulation paradigms in a single fascicle and thereafter implanted two TIMEs. We also tested its stimulation using two different waveforms. The results highlighted the versatility of this new stimulation device and advocated for the parameterizing of a hyperpolarizing phase before depolarization as well as the use of small pulse widths when stimulating with multiple electrodes. 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