b5a049d824064f61b38d21a9fcb8c8cf pmc_34771697.pdf 0150c8fe54f72a5f40b78e71beed10493173bac4 pmc_34771697.pdf a166f8f854abe08695fdc75fdb8927d36d0c346b48d4cd7fbd0eebcf7c8d655a pmc_34771697.pdf Title: Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas Subject: The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein–Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed. Keywords: Epstein–Barr virus; human immunodeficiency virus; HIV-related lymphomas Author: Miriam Verdu-Bou, Gustavo Tapia, Agueda Hernandez-Rodriguez and Jose-Tomas Navarro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Nov 8 11:59:35 2021 CET ModDate: Mon Nov 8 12:02:49 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1104873 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OHKNFJ+VnURWPalladioL Type 1 Custom yes yes no 10 0 QOPUFG+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 WPENRL+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 JJWSPE+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 33 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 55 0 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Etiopathogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Impact of EBV on Clinical Features and Prognosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Implications of EBV Load in HIV-Related Lymphoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: General Recommendations for the Treatment of Lymphomas in PLWH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: EBV-Targeted Therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Info: Title: Clinical and Therapeutic Implications of Epstein Barr Virus in HIV-Related Lymphomas Author: Miriam Verdu-Bou, Gustavo Tapia, Agueda Hernandez-Rodriguez and Jose-Tomas Navarro Subject: The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed. 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401, 548 Annotation: Subtype: Link Rect: 407, 537, 444, 548 Annotation: Subtype: Link Rect: 194, 515, 231, 525 Annotation: Subtype: Link Rect: 238, 515, 274, 525 Annotation: Subtype: Link Rect: 104, 480, 142, 490 Annotation: Subtype: Link Rect: 349, 456, 387, 467 Annotation: Subtype: Link Rect: 59, 423, 97, 433 Annotation: Subtype: Link Rect: 299, 399, 337, 410 Annotation: Subtype: Link Rect: 59, 365, 97, 375 Annotation: Subtype: Link Rect: 281, 341, 318, 352 Annotation: Subtype: Link Rect: 440, 307, 478, 318 Annotation: Subtype: Link Rect: 484, 307, 520, 318 Annotation: Subtype: Link Rect: 282, 284, 320, 295 Annotation: Subtype: Link Rect: 326, 284, 362, 295 Annotation: Subtype: Link Rect: 59, 238, 97, 249 Annotation: Subtype: Link Rect: 344, 203, 382, 214 Annotation: Subtype: Link Rect: 366, 180, 403, 191 Annotation: Subtype: Link Rect: 409, 180, 445, 191 Annotation: Subtype: Link Rect: 333, 157, 370, 168 Annotation: Subtype: Link Rect: 377, 157, 413, 168 Annotation: Subtype: Link Rect: 200, 123, 238, 134 Annotation: Subtype: Link Rect: 244, 123, 280, 134 Annotation: Subtype: Link Rect: 136, 100, 173, 111 Annotation: Subtype: Link Rect: 179, 100, 215, 111 Annotation: Subtype: Link Rect: 403, 65, 440, 76 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 149, 710, 187, 720 Annotation: Subtype: Link Rect: 252, 675, 289, 686 Annotation: Subtype: Link Rect: 194, 653, 231, 663 Annotation: Subtype: Link Rect: 229, 630, 266, 640 Annotation: Subtype: Link Rect: 477, 594, 514, 605 Annotation: Subtype: Link Rect: 453, 583, 490, 594 Annotation: Subtype: Link Rect: 307, 560, 344, 571 Annotation: Subtype: Link Rect: 348, 537, 386, 548 Annotation: Subtype: Link Rect: 392, 537, 428, 548 Annotation: Subtype: Link Rect: 463, 502, 501, 513 Annotation: Subtype: Link Rect: 507, 502, 543, 513 Annotation: Subtype: Link Rect: 59, 480, 97, 490 Annotation: Subtype: Link Rect: 103, 480, 139, 490 Annotation: Subtype: Link Rect: 366, 456, 404, 467 Annotation: Subtype: Link Rect: 402, 433, 440, 444 Annotation: Subtype: Link Rect: 495, 422, 533, 433 Annotation: Subtype: Link Rect: 504, 410, 541, 421 Annotation: Subtype: Link Rect: 476, 387, 513, 398 Annotation: Subtype: Link Rect: 281, 353, 318, 364 Annotation: Subtype: Link Rect: 458, 341, 495, 352 Annotation: Subtype: Link Rect: 413, 318, 450, 329 Annotation: Subtype: Link Rect: 520, 295, 557, 306 Annotation: Subtype: Link Rect: 59, 285, 95, 295 Annotation: Subtype: Link Rect: 474, 261, 512, 272 Annotation: Subtype: Link Rect: 59, 227, 97, 237 Annotation: Subtype: Link Rect: 103, 227, 139, 237 Annotation: Subtype: Link Rect: 59, 192, 97, 203 Annotation: Subtype: Link Rect: 406, 169, 444, 180 Annotation: Subtype: Link Rect: 109, 146, 146, 157 Annotation: Subtype: Link Rect: 153, 146, 189, 157 Annotation: Subtype: Link Rect: 351, 111, 389, 122 Annotation: Subtype: Link Rect: 140, 77, 178, 88 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 397, 721, 434, 732 Annotation: Subtype: Link Rect: 440, 721, 476, 732 Annotation: Subtype: Link Rect: 59, 687, 97, 697 Annotation: Subtype: Link Rect: 459, 652, 496, 663 Annotation: Subtype: Link Rect: 502, 652, 539, 663 Annotation: Subtype: Link Rect: 481, 629, 519, 640 Annotation: Subtype: Link Rect: 188, 595, 226, 605 Annotation: Subtype: Link Rect: 310, 560, 348, 571 Annotation: Subtype: Link Rect: 104, 526, 142, 536 Annotation: Subtype: Link Rect: 501, 468, 539, 479 Annotation: Subtype: Link Rect: 59, 434, 97, 444 Annotation: Subtype: Link Rect: 103, 434, 139, 444 Annotation: Subtype: Link Rect: 131, 400, 168, 410 Annotation: Subtype: Link Rect: 296, 364, 333, 375 Annotation: Subtype: Link Rect: 339, 364, 375, 375 Annotation: Subtype: Link Rect: 511, 341, 549, 352 Annotation: Subtype: Link Rect: 408, 307, 446, 318 Annotation: Subtype: Link Rect: 136, 273, 173, 283 Annotation: Subtype: Link Rect: 179, 273, 216, 283 Annotation: Subtype: Link Rect: 302, 238, 340, 249 Annotation: Subtype: Link Rect: 109, 204, 146, 214 Annotation: Subtype: Link Rect: 471, 180, 509, 191 Annotation: Subtype: Link Rect: 406, 146, 443, 157 Annotation: Subtype: Link Rect: 95, 112, 133, 122 Annotation: Subtype: Link Rect: 139, 112, 175, 122 Annotation: Subtype: Link Rect: 296, 77, 334, 88 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 210, 709, 247, 720 Annotation: Subtype: Link Rect: 451, 686, 488, 697 Annotation: Subtype: Link Rect: 315, 652, 352, 663 Annotation: Subtype: Link Rect: 104, 618, 142, 628 Annotation: Subtype: Link Rect: 59, 595, 97, 605 Annotation: Subtype: Link Rect: 103, 595, 139, 605 Annotation: Subtype: Link Rect: 175, 571, 212, 582 Annotation: Subtype: Link Rect: 416, 560, 453, 571 Annotation: Subtype: Link Rect: 59, 538, 97, 548 Annotation: Subtype: Link Rect: 169, 515, 207, 525 Annotation: Subtype: Link Rect: 398, 491, 436, 502 Annotation: Subtype: Link Rect: 359, 468, 397, 479 Annotation: Subtype: Link Rect: 240, 434, 278, 444 Annotation: Subtype: Link Rect: 175, 411, 212, 421 Annotation: Subtype: Link Rect: 519, 387, 556, 398 Annotation: Subtype: Link Rect: 160, 354, 198, 364 Annotation: Subtype: Link Rect: 520, 341, 557, 352 Annotation: Subtype: Link Rect: 328, 318, 365, 329 Annotation: Subtype: Link Rect: 349, 285, 386, 295 Annotation: Subtype: Link Rect: 331, 261, 368, 272 Annotation: Subtype: Link Rect: 350, 226, 387, 237 Annotation: Subtype: Link Rect: 520, 203, 557, 214 Annotation: Subtype: Link Rect: 403, 180, 440, 191 Annotation: Subtype: Link Rect: 465, 157, 503, 168 Annotation: Subtype: Link Rect: 509, 157, 545, 168 Annotation: Subtype: Link Rect: 414, 134, 451, 145 Annotation: Subtype: Link Rect: 435, 123, 472, 134 Annotation: Subtype: Link Rect: 291, 88, 329, 99 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 207, 710, 245, 720 Annotation: Subtype: Link Rect: 251, 710, 287, 720 Annotation: Subtype: Link Rect: 314, 675, 351, 686 Annotation: Subtype: Link Rect: 59, 641, 97, 651 Annotation: Subtype: Link Rect: 167, 607, 205, 617 Annotation: Subtype: Link Rect: 200, 571, 237, 582 Annotation: Subtype: Link Rect: 59, 526, 97, 536 Annotation: Subtype: Link Rect: 201, 491, 238, 502 Annotation: Subtype: Link Rect: 261, 457, 299, 467 Annotation: Subtype: Link Rect: 305, 457, 341, 467 Annotation: Subtype: Link Rect: 302, 422, 339, 433 Annotation: Subtype: Link Rect: 477, 387, 515, 398 Annotation: Subtype: Link Rect: 521, 387, 557, 398 Checksum: 77443d25 Type: CRC32 Checksum: b5a049d824064f61b38d21a9fcb8c8cf Type: MD5 Checksum: 0150c8fe54f72a5f40b78e71beed10493173bac4 Type: SHA-1