e7d75325851eeb486eb9b88aae868755 pmc_34778332.pdf 864f8bb4c86df33a3bdfc71767cf50f0fc74f38b pmc_34778332.pdf 5b42bd4ec5d2ca7d2445896c788b181d860f3c6719d6b49678ea4788d6773ca6 pmc_34778332.pdf Title: Present and Future Therapeutic Approaches to Barrier Dysfunction Subject: There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. Keywords: epithelial barrier function, intestinal permeability, nutrients, short chain fatty acids, prebiotics, probiotics, mast cell stabilizers, mucoprotectants Author: Carmen Alonso-Cotoner Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Oct 28 13:42:43 2021 CEST ModDate: Thu Oct 28 13:46:09 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 31 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 3533044 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TVHHNL+MinionPro-Regular Type 1C Custom yes yes no 86 0 FLFDYK+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 84 0 EVKKJV+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 68 0 MIQEBG+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 66 0 FMRKTR+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 49 0 ZZGNAY+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 44 0 IIQOQB+MinionPro-Bold Type 1C Custom yes yes no 98 0 AIWCSK+MinionPro-It Type 1C Custom yes yes no 96 0 GPNGZO+HelveticaNeueLTStd-Md Type 1C WinAnsi yes yes no 110 0 RCUTOR+MTGU Type 1C Custom yes yes no 100 0 YUSBPI+RMTMI Type 1C Custom yes yes no 135 0 ONSLJF+MTSY Type 1C Custom yes yes yes 133 0 ROUONJ+MTGUB Type 1C Custom yes yes no 508 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:38:18 CEST RepresentationInformation: pmc_34778332.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:06:15 CEST Size: 3533044 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1346 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: ぐひづびづのぴ〠ちのつ〠うふぴふひづ〠ごとづひちばづふぴどっ〠ぁばばひはちっとづび〠ぴは〠あちひひどづひ〠いべびてふのっぴどはの Destination: ariclecounter.1 Children: Item: Title: ぉのぴひはつふっぴどはの Destination: section*.2 Item: Title: ぁばばひはちっと〠ぴは〠きちのちでづねづのぴ Destination: section*.3 Children: Item: Title: ぎふぴひどづのぴび Destination: section*.4 Children: Item: Title: いどづぴちひべ〠うどぢづひび〬〠ぐひづぢどはぴどっび〬〠ちのつ〠ことはひぴ〭ぃとちどの〠うちぴぴべ〠ぁっどつび〠 Destination: section*.5 Item: Title: ざどぴちねどのび〠 Destination: section*.6 Item: Title: ぁねどのは〠ぁっどつび Destination: section*.7 Item: Title: きどのづひちぬび Destination: section*.8 Item: Title: きどっひはぢどはぴち〭あちびづつ〠うちっぴはひび Destination: section*.9 Children: Item: Title: ぁのぴどぢどはぴどっび Destination: section*.10 Item: Title: ぐひはぢどはぴどっび〠 Destination: section*.11 Item: Title: あどはちっぴどぶづ〠ぐとちひねちっづふぴどっちぬ〠きはぬづっふぬづび〠ちのつ〠こどでのちぬどので〠ぐづばぴどつづ〭あちびづつ〠ごとづひちばづふぴどっ〠こぴひちぴづでどづび Destination: section*.12 Children: Item: Title: ぇぬふっちではの〭がどにづ〠ぐづばぴどつづ〠〲 Destination: section*.13 Item: Title: ぃはひぴどっはぴひはばどの〭げづぬづちびどので〠うちっぴはひ Destination: section*.14 Item: Title: えふねちのどぺづつ〠ぁのぴどぢはつどづび〠ぁでちどのびぴ〠ごふねはひ〠ぎづっひはびどび〠うちっぴはひ〭㎱ Destination: section*.15 Item: Title: ぉのぴづひてづひはの〭ぇちねねち〠〨ぉうぎ〭㎳〩 Destination: section*.16 Item: Title: えふねちのどぺづつ〠ぁのぴどぢはつどづび〠ぁでちどのびぴ〠ぉのぴづひぬづふにどの〭〱〳 Destination: section*.17 Item: Title: がちひちぺはぴどつづ〠 Destination: section*.18 Item: Title: がふぢどばひはびぴはのづ Destination: section*.19 Item: Title: いづへねづつづぴはねどつどのづ〠 Destination: section*.20 Item: Title: きちびぴ〠ぃづぬぬ〠こぴちぢどぬどぺづひび〠ちのつ〠うぬちぶはのはどつび Destination: section*.21 Item: Title: ぇぬふっはっはひぴどっはどつび Destination: section*.22 Item: Title: きふっはばひはぴづっぴはひび〠 Destination: section*.23 Children: Item: Title: じべぬはでぬふっちの Destination: section*.24 Item: Title: ぇづぬちぴどのづ〠ごちののちぴづ Destination: section*.25 Item: Title: いどはびねづっぴどぴづ Destination: section*.26 Item: Title: ぅばどでづのづぴどっ〠ちのつ〠ぅへはびはねづ〭きづつどちぴづつ〠げづでふぬちぴどはの〠はて〠ぉのぴづびぴどのちぬ〠あちひひどづひ〠うふのっぴどはの Destination: section*.27 Item: Title: こふねねちひべ〠ちのつ〠ぃはのっぬふびどはのび Destination: section*.28 Item: Title: ぁふぴとはひ〠ぃはのぴひどぢふぴどはのび Destination: section*.29 Item: Title: うふのつどので Destination: section*.30 Item: Title: げづてづひづのっづび Destination: section*.31 Info: Title: Present and Future Therapeutic Approaches to Barrier Dysfunction Author: Carmen Alonso-Cotoner Subject: There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. Keywords: epithelial barrier function, intestinal permeability, nutrients, short chain fatty acids, prebiotics, probiotics, mast cell stabilizers, mucoprotectants Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Oct 28 14:12:43 CEST 2021 ModDate: Thu Oct 28 14:16:09 CEST 2021 ID: 0xf806da3947a74ceced6bbca839029a5a, 0x910837894ba7b34ebf1c19e617dd7d57 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1177 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1514 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1690 BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: 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human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. epithelial barrier function intestinal permeability nutrients short chain fatty acids prebiotics probiotics mast cell stabilizers mucoprotectants Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 136, 755 Annotation: Subtype: Link Rect: 522, 736, 551, 744 Annotation: Subtype: Link Rect: 464, 728, 507, 736 Annotation: Subtype: Link Rect: 507, 729, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 454, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 31, 105, 38 Annotation: Subtype: Link Rect: 109, 30, 169, 38 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 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Annotation: Subtype: Link Rect: 487, 181, 503, 193 Destination: External Annotation: Subtype: Link Rect: 506, 181, 521, 193 Destination: External Annotation: Subtype: Link Rect: 436, 147, 452, 158 Destination: External Annotation: Subtype: Link Rect: 530, 135, 546, 147 Destination: External Annotation: Subtype: Link Rect: 415, 113, 430, 124 Destination: External Annotation: Subtype: Link Rect: 432, 113, 448, 124 Destination: External Annotation: Subtype: Link Rect: 369, 78, 384, 90 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 81, 697, 96, 708 Destination: External Annotation: Subtype: Link Rect: 228, 628, 243, 640 Destination: External Annotation: Subtype: Link Rect: 109, 582, 125, 594 Destination: External Annotation: Subtype: Link Rect: 258, 559, 274, 571 Destination: External Annotation: Subtype: Link Rect: 159, 525, 174, 536 Destination: External Annotation: Subtype: Link Rect: 79, 491, 86, 502 Destination: External Annotation: Subtype: Link Rect: 207, 456, 223, 468 Destination: External Annotation: Subtype: Link Rect: 260, 433, 276, 445 Destination: External Annotation: Subtype: Link Rect: 175, 410, 191, 422 Destination: External Annotation: Subtype: Link Rect: 47, 284, 62, 296 Destination: External Annotation: Subtype: Link Rect: 270, 193, 285, 204 Destination: External Annotation: Subtype: Link Rect: 97, 147, 112, 158 Destination: External Annotation: Subtype: Link Rect: 209, 101, 224, 113 Destination: External Annotation: Subtype: Link Rect: 254, 78, 269, 90 Destination: External Annotation: Subtype: Link Rect: 428, 708, 444, 720 Destination: External Annotation: Subtype: Link Rect: 307, 685, 323, 697 Destination: External Annotation: Subtype: Link Rect: 307, 662, 323, 674 Destination: External Annotation: Subtype: Link Rect: 327, 662, 343, 674 Destination: External Annotation: Subtype: Link Rect: 376, 651, 387, 662 Destination: External Annotation: Subtype: Link Rect: 452, 628, 468, 640 Destination: External Annotation: Subtype: Link Rect: 307, 571, 323, 582 Destination: External Annotation: Subtype: Link Rect: 351, 548, 367, 559 Destination: External Annotation: Subtype: Link Rect: 465, 525, 480, 536 Destination: External Annotation: Subtype: Link Rect: 483, 525, 499, 536 Destination: External Annotation: Subtype: Link Rect: 307, 502, 323, 514 Destination: External Annotation: Subtype: Link Rect: 475, 491, 491, 502 Destination: External Annotation: Subtype: Link Rect: 478, 468, 494, 479 Destination: External Annotation: Subtype: Link Rect: 497, 468, 512, 479 Destination: External Annotation: Subtype: Link Rect: 493, 433, 509, 445 Destination: External Annotation: Subtype: Link Rect: 307, 375, 323, 386 Destination: External Annotation: Subtype: Link Rect: 325, 375, 340, 386 Destination: External Annotation: Subtype: Link Rect: 307, 296, 323, 307 Destination: External Annotation: Subtype: Link Rect: 398, 296, 414, 307 Destination: External Annotation: Subtype: Link Rect: 383, 284, 399, 296 Destination: External Annotation: Subtype: Link Rect: 307, 261, 323, 273 Destination: External Annotation: Subtype: Link Rect: 328, 261, 343, 273 Destination: External Annotation: Subtype: Link Rect: 445, 227, 461, 239 Destination: External Annotation: Subtype: Link Rect: 307, 193, 323, 204 Destination: External Annotation: Subtype: Link Rect: 384, 135, 400, 147 Destination: External Annotation: Subtype: Link Rect: 358, 78, 374, 90 Destination: External Annotation: Subtype: Link Rect: 376, 78, 392, 90 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 241, 685, 256, 697 Destination: External Annotation: Subtype: Link Rect: 259, 685, 274, 697 Destination: External Annotation: Subtype: Link Rect: 120, 674, 136, 685 Destination: External Annotation: Subtype: Link Rect: 270, 582, 285, 594 Destination: External Annotation: Subtype: Link Rect: 270, 536, 285, 548 Destination: External Annotation: Subtype: Link Rect: 272, 502, 287, 514 Destination: External Annotation: Subtype: Link Rect: 110, 479, 125, 491 Destination: External Annotation: Subtype: Link Rect: 108, 388, 124, 399 Destination: External Annotation: Subtype: Link Rect: 170, 342, 185, 353 Destination: External Annotation: Subtype: Link Rect: 47, 307, 62, 319 Destination: External Annotation: Subtype: Link Rect: 186, 284, 201, 296 Destination: External Annotation: Subtype: Link Rect: 106, 250, 121, 261 Destination: External Annotation: Subtype: Link Rect: 250, 193, 266, 204 Destination: External Annotation: Subtype: Link Rect: 270, 193, 285, 204 Destination: External Annotation: Subtype: Link Rect: 99, 147, 114, 158 Destination: External Annotation: Subtype: Link Rect: 83, 101, 99, 113 Destination: External Annotation: Subtype: Link Rect: 47, 67, 62, 78 Destination: External Annotation: Subtype: Link Rect: 346, 685, 361, 697 Destination: External Annotation: Subtype: Link Rect: 478, 628, 494, 640 Destination: External Annotation: Subtype: Link Rect: 510, 605, 526, 617 Destination: External Annotation: Subtype: Link Rect: 530, 605, 546, 617 Destination: External Annotation: Subtype: Link Rect: 505, 559, 520, 571 Destination: External Annotation: Subtype: Link Rect: 434, 491, 449, 502 Destination: External Annotation: Subtype: Link Rect: 349, 445, 365, 456 Destination: External Annotation: Subtype: Link Rect: 475, 410, 490, 422 Destination: External Annotation: Subtype: Link Rect: 339, 353, 354, 365 Destination: External Annotation: Subtype: Link Rect: 307, 319, 323, 330 Destination: External Annotation: Subtype: Link Rect: 388, 296, 403, 307 Destination: External Annotation: Subtype: Link Rect: 354, 273, 370, 284 Destination: External Annotation: Subtype: Link Rect: 530, 181, 546, 193 Destination: External Annotation: Subtype: Link Rect: 454, 170, 470, 181 Destination: External Annotation: Subtype: Link Rect: 346, 101, 362, 113 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 47, 640, 62, 651 Destination: External Annotation: Subtype: Link Rect: 216, 605, 232, 617 Destination: External Annotation: Subtype: Link Rect: 89, 548, 105, 559 Destination: External Annotation: Subtype: Link Rect: 248, 491, 263, 502 Destination: External Annotation: Subtype: Link Rect: 214, 422, 230, 433 Destination: External Annotation: Subtype: Link Rect: 112, 388, 128, 399 Destination: External Annotation: Subtype: Link Rect: 270, 296, 285, 307 Destination: External Annotation: Subtype: Link Rect: 94, 204, 110, 216 Destination: External Annotation: Subtype: Link Rect: 47, 158, 62, 170 Destination: External Annotation: Subtype: Link Rect: 270, 135, 285, 147 Destination: External Annotation: Subtype: Link Rect: 446, 655, 481, 665 Destination: External Annotation: Subtype: Link Rect: 393, 622, 408, 634 Destination: External Annotation: Subtype: Link Rect: 412, 622, 427, 634 Destination: External Annotation: Subtype: Link Rect: 307, 600, 323, 611 Destination: External Annotation: Subtype: Link Rect: 325, 565, 341, 577 Destination: External Annotation: Subtype: Link Rect: 343, 565, 359, 577 Destination: External Annotation: Subtype: Link Rect: 361, 565, 377, 577 Destination: External Annotation: Subtype: Link Rect: 458, 542, 469, 554 Destination: External Annotation: Subtype: Link Rect: 473, 542, 489, 554 Destination: External Annotation: Subtype: Link Rect: 492, 542, 508, 554 Destination: External Annotation: Subtype: Link Rect: 344, 508, 360, 519 Destination: External Annotation: Subtype: Link Rect: 468, 451, 484, 462 Destination: External Annotation: Subtype: Link Rect: 486, 451, 502, 462 Destination: External Annotation: Subtype: Link Rect: 436, 416, 451, 428 Destination: External Annotation: Subtype: Link Rect: 457, 416, 473, 428 Destination: External Annotation: Subtype: Link Rect: 341, 370, 357, 382 Destination: External Annotation: Subtype: Link Rect: 457, 336, 473, 347 Destination: External Annotation: Subtype: Link Rect: 509, 267, 525, 279 Destination: External Annotation: Subtype: Link Rect: 530, 267, 546, 279 Destination: External Annotation: Subtype: Link Rect: 471, 210, 487, 221 Destination: External Annotation: Subtype: Link Rect: 396, 153, 412, 164 Destination: External Annotation: Subtype: Link Rect: 450, 130, 466, 141 Destination: External Annotation: Subtype: Link Rect: 495, 95, 511, 107 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 182, 110, 198, 122 Destination: External Annotation: Subtype: Link Rect: 202, 110, 218, 122 Destination: External Annotation: Subtype: Link Rect: 251, 87, 267, 99 Destination: External Annotation: Subtype: Link Rect: 270, 87, 285, 99 Destination: External Annotation: Subtype: Link Rect: 461, 122, 477, 133 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 47, 637, 81, 648 Destination: External Annotation: Subtype: Link Rect: 227, 559, 242, 571 Destination: External Annotation: Subtype: Link Rect: 245, 559, 261, 571 Destination: External Annotation: Subtype: Link Rect: 121, 468, 136, 479 Destination: External Annotation: Subtype: Link Rect: 139, 468, 155, 479 Destination: External Annotation: Subtype: Link Rect: 195, 445, 210, 456 Destination: External Annotation: Subtype: Link Rect: 214, 445, 229, 456 Destination: External Annotation: Subtype: Link Rect: 232, 445, 248, 456 Destination: External Annotation: Subtype: Link Rect: 82, 410, 97, 422 Destination: External Annotation: Subtype: Link Rect: 123, 376, 139, 388 Destination: External Annotation: Subtype: Link Rect: 47, 342, 62, 353 Destination: External Annotation: Subtype: Link Rect: 66, 342, 82, 353 Destination: External Annotation: Subtype: Link Rect: 85, 342, 100, 353 Destination: External Annotation: Subtype: Link Rect: 91, 296, 107, 307 Destination: External Annotation: Subtype: Link Rect: 128, 227, 143, 239 Destination: External Annotation: Subtype: Link Rect: 147, 227, 163, 239 Destination: External Annotation: Subtype: Link Rect: 166, 227, 181, 239 Destination: External Annotation: Subtype: Link Rect: 185, 227, 201, 239 Destination: External Annotation: Subtype: Link Rect: 205, 227, 220, 239 Destination: External Annotation: Subtype: Link Rect: 223, 227, 239, 239 Destination: External Annotation: Subtype: Link Rect: 132, 216, 148, 227 Destination: External Annotation: Subtype: Link Rect: 240, 170, 255, 181 Destination: External Annotation: Subtype: Link Rect: 249, 124, 265, 135 Destination: External Annotation: Subtype: Link Rect: 270, 124, 285, 135 Destination: External Annotation: Subtype: Link Rect: 99, 90, 114, 101 Destination: External Annotation: Subtype: Link Rect: 93, 67, 108, 78 Destination: External Annotation: Subtype: Link Rect: 111, 67, 127, 78 Destination: External Annotation: Subtype: Link Rect: 454, 637, 489, 648 Destination: External Annotation: Subtype: Link Rect: 414, 617, 430, 628 Destination: External Annotation: Subtype: Link Rect: 461, 571, 476, 582 Destination: External Annotation: Subtype: Link Rect: 307, 502, 323, 514 Destination: External Annotation: Subtype: Link Rect: 314, 479, 329, 491 Destination: External Annotation: Subtype: Link Rect: 307, 445, 323, 456 Destination: External Annotation: Subtype: Link Rect: 325, 445, 341, 456 Destination: External Annotation: Subtype: Link Rect: 374, 388, 390, 399 Destination: External Annotation: Subtype: Link Rect: 509, 376, 524, 388 Destination: External Annotation: Subtype: Link Rect: 530, 376, 546, 388 Destination: External Annotation: Subtype: Link Rect: 371, 330, 386, 342 Destination: External Annotation: Subtype: Link Rect: 530, 307, 546, 319 Destination: External Annotation: Subtype: Link Rect: 304, 296, 319, 307 Destination: External Annotation: Subtype: Link Rect: 530, 273, 546, 284 Destination: External Annotation: Subtype: Link Rect: 428, 204, 444, 216 Destination: External Annotation: Subtype: Link Rect: 512, 170, 528, 181 Destination: External Annotation: Subtype: Link Rect: 530, 170, 546, 181 Destination: External Annotation: Subtype: Link Rect: 304, 158, 319, 170 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 108, 708, 124, 720 Destination: External Annotation: Subtype: Link Rect: 113, 651, 129, 662 Destination: External Annotation: Subtype: Link Rect: 219, 651, 235, 662 Destination: External Annotation: Subtype: Link Rect: 191, 617, 206, 628 Destination: External Annotation: Subtype: Link Rect: 268, 536, 284, 548 Destination: External Annotation: Subtype: Link Rect: 47, 422, 62, 433 Destination: External Annotation: Subtype: Link Rect: 71, 420, 105, 430 Destination: External Annotation: Subtype: Link Rect: 82, 353, 97, 365 Destination: External Annotation: Subtype: Link Rect: 102, 353, 117, 365 Destination: External Annotation: Subtype: Link Rect: 47, 330, 62, 342 Destination: External Annotation: Subtype: Link Rect: 214, 273, 230, 284 Destination: External Annotation: Subtype: Link Rect: 251, 250, 267, 261 Destination: External Annotation: Subtype: Link Rect: 270, 250, 285, 261 Destination: External Annotation: Subtype: Link Rect: 184, 204, 199, 216 Destination: External Annotation: Subtype: Link Rect: 124, 158, 140, 170 Destination: External Annotation: Subtype: Link Rect: 142, 158, 158, 170 Destination: External Annotation: Subtype: Link Rect: 184, 147, 200, 158 Destination: External Annotation: Subtype: Link Rect: 149, 113, 165, 124 Destination: External Annotation: Subtype: Link Rect: 376, 708, 392, 720 Destination: External Annotation: Subtype: Link Rect: 399, 706, 433, 716 Destination: External Annotation: Subtype: Link Rect: 407, 662, 423, 674 Destination: External Annotation: Subtype: Link Rect: 427, 662, 443, 674 Destination: External Annotation: Subtype: Link Rect: 445, 640, 460, 651 Destination: External Annotation: Subtype: Link Rect: 512, 605, 527, 617 Destination: External Annotation: Subtype: Link Rect: 388, 571, 404, 582 Destination: External Annotation: Subtype: Link Rect: 391, 502, 406, 514 Destination: External Annotation: Subtype: Link Rect: 434, 468, 450, 479 Destination: External Annotation: Subtype: Link Rect: 380, 422, 396, 433 Destination: External Annotation: Subtype: Link Rect: 399, 422, 415, 433 Destination: External Annotation: Subtype: Link Rect: 509, 307, 525, 319 Destination: External Annotation: Subtype: Link Rect: 530, 307, 546, 319 Destination: External Annotation: Subtype: Link Rect: 408, 158, 424, 170 Destination: External Annotation: Subtype: Link Rect: 432, 156, 467, 166 Destination: External Annotation: Subtype: Link Rect: 358, 113, 374, 124 Destination: External Annotation: Subtype: Link Rect: 467, 78, 482, 90 Destination: External Annotation: Subtype: Link Rect: 453, 67, 469, 78 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 15 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 125, 697, 141, 708 Destination: External Annotation: Subtype: Link Rect: 254, 697, 270, 708 Destination: External Annotation: Subtype: Link Rect: 145, 685, 160, 697 Destination: External Annotation: Subtype: Link Rect: 163, 685, 178, 697 Destination: External Annotation: Subtype: Link Rect: 126, 662, 141, 674 Destination: External Annotation: Subtype: Link Rect: 144, 662, 160, 674 Destination: External Annotation: Subtype: Link Rect: 163, 662, 178, 674 Destination: External Annotation: Subtype: Link Rect: 47, 580, 116, 591 Annotation: Subtype: Link Rect: 47, 445, 62, 456 Destination: External Annotation: Subtype: Link Rect: 65, 445, 81, 456 Destination: External Annotation: Subtype: Link Rect: 91, 443, 126, 453 Destination: External Annotation: Subtype: Link Rect: 76, 399, 92, 410 Destination: External Annotation: Subtype: Link Rect: 79, 365, 95, 376 Destination: External Annotation: Subtype: Link Rect: 81, 319, 97, 330 Destination: External Annotation: Subtype: Link Rect: 213, 307, 229, 319 Destination: External Annotation: Subtype: Link Rect: 162, 273, 178, 284 Destination: External Annotation: Subtype: Link Rect: 180, 273, 195, 284 Destination: External Annotation: Subtype: Link Rect: 85, 239, 101, 250 Destination: External Annotation: Subtype: Link Rect: 103, 193, 118, 204 Destination: External Annotation: Subtype: Link Rect: 157, 133, 191, 144 Destination: External Annotation: Subtype: Link Rect: 161, 67, 176, 78 Destination: External Annotation: Subtype: Link Rect: 307, 697, 323, 708 Destination: External Annotation: Subtype: Link Rect: 478, 685, 493, 697 Destination: External Annotation: Subtype: Link Rect: 530, 651, 546, 662 Destination: External Annotation: Subtype: Link Rect: 368, 617, 383, 628 Destination: External Annotation: Subtype: Link Rect: 355, 594, 371, 605 Destination: External Annotation: Subtype: Link Rect: 433, 559, 448, 571 Destination: External Annotation: Subtype: Link Rect: 437, 502, 452, 514 Destination: External Annotation: Subtype: Link Rect: 413, 456, 429, 468 Destination: External Annotation: Subtype: Link Rect: 421, 410, 437, 422 Destination: External Annotation: Subtype: Link Rect: 416, 374, 451, 384 Destination: External Annotation: Subtype: Link Rect: 307, 342, 323, 353 Destination: External Annotation: Subtype: Link Rect: 445, 284, 460, 296 Destination: External Annotation: Subtype: Link Rect: 463, 284, 479, 296 Destination: External Annotation: Subtype: Link Rect: 444, 239, 460, 250 Destination: External Annotation: Subtype: Link Rect: 463, 239, 478, 250 Destination: External Annotation: Subtype: Link Rect: 481, 239, 497, 250 Destination: External Annotation: Subtype: Link Rect: 372, 170, 387, 181 Destination: External Annotation: Subtype: Link Rect: 362, 147, 378, 158 Destination: External Annotation: Subtype: Link Rect: 330, 124, 345, 135 Destination: External Annotation: Subtype: Link Rect: 392, 113, 408, 124 Destination: External Annotation: Subtype: Link Rect: 349, 90, 365, 101 Destination: External Annotation: Subtype: Link Rect: 336, 67, 352, 78 Destination: External Annotation: Subtype: Link Rect: 356, 67, 372, 78 Destination: External Annotation: Subtype: Link Rect: 444, 67, 460, 78 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 16 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 129, 708, 145, 720 Destination: External Annotation: Subtype: Link Rect: 270, 708, 285, 720 Destination: External Annotation: Subtype: Link Rect: 86, 674, 102, 685 Destination: External Annotation: Subtype: Link Rect: 104, 674, 120, 685 Destination: External Annotation: Subtype: Link Rect: 195, 628, 210, 640 Destination: External Annotation: Subtype: Link Rect: 138, 605, 153, 617 Destination: External Annotation: Subtype: Link Rect: 270, 559, 286, 571 Destination: External Annotation: Subtype: Link Rect: 43, 548, 59, 559 Destination: External Annotation: Subtype: Link Rect: 47, 491, 62, 502 Destination: External Annotation: Subtype: Link Rect: 64, 491, 80, 502 Destination: External Annotation: Subtype: Link Rect: 82, 491, 97, 502 Destination: External Annotation: Subtype: Link Rect: 99, 491, 115, 502 Destination: External Annotation: Subtype: Link Rect: 118, 491, 134, 502 Destination: External Annotation: Subtype: Link Rect: 191, 468, 207, 479 Destination: External Annotation: Subtype: Link Rect: 209, 468, 225, 479 Destination: External Annotation: Subtype: Link Rect: 227, 468, 242, 479 Destination: External Annotation: Subtype: Link Rect: 267, 445, 282, 456 Destination: External Annotation: Subtype: Link Rect: 145, 408, 179, 419 Destination: External Annotation: Subtype: Link Rect: 161, 388, 177, 399 Destination: External Annotation: Subtype: Link Rect: 107, 376, 122, 388 Destination: External Annotation: Subtype: Link Rect: 79, 353, 95, 365 Destination: External Annotation: Subtype: Link Rect: 243, 330, 259, 342 Destination: External Annotation: Subtype: Link Rect: 230, 296, 246, 307 Destination: External Annotation: Subtype: Link Rect: 239, 284, 254, 296 Destination: External Annotation: Subtype: Link Rect: 199, 273, 215, 284 Destination: External Annotation: Subtype: Link Rect: 270, 250, 285, 261 Destination: External Annotation: Subtype: Link Rect: 270, 227, 285, 239 Destination: External Annotation: Subtype: Link Rect: 107, 204, 123, 216 Destination: External Annotation: Subtype: Link Rect: 188, 181, 203, 193 Destination: External Annotation: Subtype: Link Rect: 207, 181, 223, 193 Destination: External Annotation: Subtype: Link Rect: 201, 170, 217, 181 Destination: External Annotation: Subtype: Link Rect: 47, 135, 62, 147 Destination: External Annotation: Subtype: Link Rect: 186, 135, 202, 147 Destination: External Annotation: Subtype: Link Rect: 270, 113, 285, 124 Destination: External Annotation: Subtype: Link Rect: 177, 90, 193, 101 Destination: External Annotation: Subtype: Link Rect: 196, 90, 211, 101 Destination: External Annotation: Subtype: Link Rect: 170, 67, 186, 78 Destination: External Annotation: Subtype: Link Rect: 397, 685, 412, 697 Destination: External Annotation: Subtype: Link Rect: 441, 607, 475, 617 Destination: External Annotation: Subtype: Link Rect: 375, 586, 391, 598 Destination: External Annotation: Subtype: Link Rect: 381, 552, 396, 563 Destination: External Annotation: Subtype: Link Rect: 399, 552, 414, 563 Destination: External Annotation: Subtype: Link Rect: 397, 481, 413, 493 Destination: External Annotation: Subtype: Link Rect: 369, 470, 384, 481 Destination: External Annotation: Subtype: Link Rect: 512, 435, 528, 447 Destination: External Annotation: Subtype: Link Rect: 530, 435, 546, 447 Destination: External Annotation: Subtype: Link Rect: 422, 412, 438, 424 Destination: External Annotation: Subtype: Link Rect: 372, 367, 387, 378 Destination: External Annotation: Subtype: Link Rect: 405, 332, 420, 344 Destination: External Annotation: Subtype: Link Rect: 512, 309, 528, 321 Destination: External Annotation: Subtype: Link Rect: 532, 309, 548, 321 Destination: External Annotation: Subtype: Link Rect: 351, 298, 367, 309 Destination: External Annotation: Subtype: Link Rect: 458, 286, 473, 298 Destination: External Annotation: Subtype: Link Rect: 477, 286, 493, 298 Destination: External Annotation: Subtype: Link Rect: 470, 204, 485, 216 Destination: External Annotation: Subtype: Link Rect: 489, 204, 505, 216 Destination: External Annotation: Subtype: Link Rect: 517, 181, 532, 193 Destination: External Annotation: Subtype: Link Rect: 495, 147, 511, 158 Destination: External Annotation: Subtype: Link Rect: 500, 124, 515, 135 Destination: External Annotation: Subtype: Link Rect: 325, 101, 340, 113 Destination: External Annotation: Subtype: Link Rect: 354, 78, 369, 90 Destination: External Annotation: Subtype: Link Rect: 43, 30, 105, 37 Annotation: Subtype: Link Rect: 109, 29, 169, 37 Annotation: Subtype: Link Rect: 425, 29, 551, 38 Page: Label: 17 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 254, 697, 269, 708 Destination: External Annotation: Subtype: Link Rect: 273, 697, 289, 708 Destination: External Annotation: Subtype: Link Rect: 43, 685, 59, 697 Destination: External Annotation: Subtype: Link Rect: 150, 573, 165, 584 Destination: External Annotation: Subtype: Link Rect: 168, 573, 184, 584 Destination: External Annotation: Subtype: Link Rect: 270, 561, 285, 573 Destination: External Annotation: Subtype: Link Rect: 190, 470, 206, 481 Destination: External Annotation: Subtype: Link Rect: 209, 470, 225, 481 Destination: External Annotation: Subtype: Link Rect: 114, 412, 130, 424 Destination: External Annotation: Subtype: Link Rect: 133, 273, 149, 284 Destination: External Annotation: Subtype: Link Rect: 151, 273, 167, 284 Destination: External Annotation: Subtype: Link Rect: 226, 170, 241, 181 Destination: External Annotation: Subtype: Link Rect: 117, 101, 132, 113 Destination: External Annotation: Subtype: Link Rect: 136, 101, 152, 113 Destination: External Annotation: Subtype: Link Rect: 94, 78, 110, 90 Destination: External Annotation: Subtype: Link Rect: 112, 78, 127, 90 Destination: External Annotation: Subtype: Link Rect: 364, 697, 379, 708 Destination: External Annotation: Subtype: Link Rect: 439, 662, 455, 674 Destination: External Annotation: Subtype: Link Rect: 412, 617, 428, 628 Destination: External Annotation: Subtype: Link Rect: 333, 582, 348, 594 Destination: External Annotation: Subtype: Link Rect: 493, 536, 509, 548 Destination: External Annotation: Subtype: Link Rect: 307, 502, 323, 514 Destination: External Annotation: Subtype: Link Rect: 307, 479, 323, 491 Destination: External Annotation: Subtype: Link Rect: 326, 479, 342, 491 Destination: External Annotation: Subtype: Link Rect: 346, 479, 362, 491 Destination: External Annotation: Subtype: Link Rect: 361, 468, 376, 479 Destination: External Annotation: Subtype: Link Rect: 406, 433, 422, 445 Destination: External Annotation: Subtype: Link Rect: 464, 388, 479, 399 Destination: External Annotation: Subtype: Link Rect: 482, 388, 497, 399 Destination: External 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