0cc98c86c6cf7ad9fbff17d2119f0200 pmc_34780645.pdf 969a619d3152447ec95791ce310a0d3c9db474f5 pmc_34780645.pdf 85e5c91361cc7c3ace9d13f47fec3c34b18d1c3b4771e3b81d6532004a41c89f pmc_34780645.pdf Title: untitled Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Dec 3 06:31:22 2021 CET ModDate: Fri Dec 3 06:31:22 2021 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 788.031 pts Page rot: 0 File size: 10122687 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PBGNNM+AdvOT3a037357.I Type 1C WinAnsi yes yes no 499 0 PBGNON+AdvOTf0129623+20 Type 1C WinAnsi yes yes no 494 0 PBGNLC+AdvOTf94803d4 Type 1C WinAnsi yes yes no 466 0 PBGNLD+AdvTT3d6af1c1 Type 1C WinAnsi yes yes no 467 0 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Destination: head2 Item: Title: Introduction Destination: head3 Item: Title: Results Destination: head4 Children: Item: Title: Quantitative proteomic profiling identifies ERK5 regulated proteins in mESCs Destination: head5 Item: Title: The ERK5 pathway drives the expression of ZSCAN4 and other 2C-stage genes Destination: head6 Item: Title: ERK5-dependent ZSCAN4 induction drives telomere elongation Destination: head7 Item: Title: The ERK5–KLF2 transcriptional axis controls Zscan4/2C gene expression Destination: head8 Item: Title: ERK5 directly phosphorylates KLF2 at multiple pSer/Thr-Pro motifs Destination: head9 Item: Title: KLF2 phosphorylation drives Cullin E3 ligase recruitment and ubiquitin-dependent degradation Destination: head10 Item: Title: ERK5 phosphorylation of KLF2 confers negative feedback regulation of ZSCAN4/2C gene expression Destination: head11 Item: Title: Discussion Destination: head12 Item: Title: Experimental procedures Destination: head13 Children: Item: Title: Antibodies and chemicals Destination: head14 Item: Title: mESC culture, transfection and lysis Destination: head15 Item: Title: Quantitative proteomics Destination: head16 Children: Item: Title: Protein extraction and digestion Destination: head17 Item: Title: TMT labelling and high pH reverse phase fractionation Destination: head18 Item: Title: LC–MS/MS analysis Destination: head19 Item: Title: Data processing and spectra assignment Destination: head20 Item: Title: Immunofluorescence microscopy Destination: head21 Item: Title: RNA extraction and quantitative PCR Destination: head22 Item: Title: Recombinant ERK5 kinase assay Destination: head23 Item: Title: KLF2 phosphorylation site mapping Destination: head24 Item: Title: HALO-TUBE ubiquitin pull-down assay Destination: head25 Item: Title: Telomere qPCR assay Destination: head26 Item: Title: Statistical analysis Destination: head27 Item: Title: Data Availability Destination: head28 Item: Title: Competing Interests Destination: head29 Item: Title: Funding Destination: head30 Item: Title: CRediT Author Contribution Destination: head31 Item: Title: References Destination: head32 Info: Title: untitled Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Dec 03 07:01:22 CET 2021 ModDate: Fri Dec 03 07:01:22 CET 2021 ID: 0x838eb1dc54d975a8fc9c380da0e990a9, 0xc3e2c0252f48b24dbf9a6819b2a84f72 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 801 ImageHeight: 289 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3600 ImageHeight: 4777 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 316 ImageHeight: 115 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: 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73 Annotation: Subtype: Link Rect: 402, 27, 520, 33 Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 165, 693, 269, 701 Annotation: Subtype: Link Rect: 221, 673, 314, 681 Annotation: Subtype: Link Rect: 221, 673, 328, 681 Annotation: Subtype: Link Rect: 221, 673, 350, 681 Annotation: Subtype: Link Rect: 221, 673, 354, 681 Annotation: Subtype: Link Rect: 203, 653, 328, 661 Annotation: Subtype: Link Rect: 421, 643, 522, 651 Annotation: Subtype: Link Rect: 225, 623, 325, 631 Annotation: Subtype: Link Rect: 264, 603, 382, 611 Annotation: Subtype: Link Rect: 243, 583, 361, 591 Annotation: Subtype: Link Rect: 517, 573, 548, 581 Annotation: Subtype: Link Rect: 120, 563, 207, 571 Annotation: Subtype: Link Rect: 342, 543, 471, 551 Annotation: Subtype: Link Rect: 319, 523, 447, 531 Annotation: Subtype: Link Rect: 427, 503, 541, 511 Annotation: Subtype: Link Rect: 120, 493, 131, 501 Annotation: Subtype: Link Rect: 434, 27, 552, 33 Checksum: 7c2b2c68 Type: CRC32 Checksum: 0cc98c86c6cf7ad9fbff17d2119f0200 Type: MD5 Checksum: 969a619d3152447ec95791ce310a0d3c9db474f5 Type: SHA-1 Checksum: 85e5c91361cc7c3ace9d13f47fec3c34b18d1c3b4771e3b81d6532004a41c89f Type: SHA-256