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RepresentationInformation: pmc_34787081.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:06:16 CEST Size: 2477318 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1604 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Control of protein synthesis and memory by GluN3A-­NMDA receptors through inhibition of GIT1/mTORC1 assembly Children: Item: Title: Introduction Item: Title: Results Children: Item: Title: Selective inhibition of activity-dependent gene expression by GluN3A at the post-transcriptional level Item: Title: GluN3A inhibits mTORC1-dependent translation of IEGs Item: Title: mTORC1 inhibition requires GluN3A C-terminal domain interactions Item: Title: GluN3A expression modulates the assembly of synaptic GIT1/mTORC1 complexes Item: Title: GluN3A/GIT1 interactions control the emergence of mTORC1-dependent protein synthesis Item: Title: Long-term memory formation is enhanced in Grin3a-deficient mice in a rapamycin-dependent manner Item: Title: Discussion Children: Item: Title: Modulation by GluN3A of GIT1/mTORC1 complex assembly Item: Title: A role for GluN3A in restricting translation for precise circuit refinements and long-term memory storage Item: Title: GluN3A and synaptic protein synthesis as selective therapeutic targets Item: Title: Materials and methods Children: Item: Title: Animals Item: Title: Primary neuronal cultures Item: Title: Lentiviral vectors Item: Title: RNA isolation, qRT-PCR, and RNAseq analyses Item: Title: Protein extraction and western blotting Item: Title: Immunoprecipitation Item: Title: Proximity ligation assay Item: Title: Protein synthesis assays Item: Title: Behavioral analysis Children: Item: Title: Morris water maze Item: Title: Y-maze spontaneous alternation Item: Title: Conditioned taste aversion Item: Title: Fear conditioning and extinction Item: Title: Electrophysiology Item: Title: Statistical analysis Item: Title: Acknowledgements Item: Title: Additional information Children: Item: Title: Funding Item: Title: Author contributions Item: Title: Author ORCIDs Item: Title: Ethics Item: Title: Decision letter and Author response Item: Title: Additional files Children: Item: Title: Supplementary files Item: Title: References Info: Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu Nov 18 12:12:49 CET 2021 ModDate: Thu Nov 18 12:12:57 CET 2021 ID: 0x8c2d3fc699605643835705d04f260952, 0x4bd67e0c43c1184e998c2b1525bb323b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: 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Annotation: Subtype: Link Rect: 369, 119, 509, 109 Annotation: Subtype: Link Rect: 538, 119, 574, 109 Annotation: Subtype: Link Rect: 508, 99, 564, 89 Annotation: Subtype: Link Rect: 175, 89, 276, 79 Annotation: Subtype: Link Rect: 305, 89, 341, 79 Checksum: 7ac0fe17 Type: CRC32 Checksum: b8cdefc1e41b95eea84622a9ff863fc2 Type: MD5 Checksum: 5382fdb99832a2776981e5298da08bbfc64eb2d6 Type: SHA-1 Checksum: 0a73212df40780a2476aa2efdf0ecbfa20e1b2b79ec06921589ec462756ac787 Type: SHA-256