e80610bcc0d1807ec3318311582d419d pmc_34943043.pdf ec7b2b44d0163103af79ff8229a57a70358385d9 pmc_34943043.pdf 2f03f4b318bff3c5f6994cab4f66e00c136d9993a84d3646a35dfece2f678f11 pmc_34943043.pdf Title: Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases Subject: Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. NAD+ bioavailability decreases with age and cardiometabolic conditions in several mammalian tissues. Compelling data suggest that declining tissue NAD+ is commonly related to mitochondrial dysfunction and might be considered as a therapeutic target. Thus, NAD+ replenishment by either genetic or natural dietary NAD+-increasing strategies has been recently demonstrated to be effective for improving the pathophysiology of cardiac and vascular health in different experimental models, as well as human health, to a lesser extent. Here, we review and discuss recent experimental evidence illustrating that increasing NAD+ bioavailability, particularly by the use of natural NAD+ precursors, may offer hope for new therapeutic strategies to prevent and treat cardiovascular diseases. Keywords: macrophage; aneurysm; atherosclerosis; ischemia/reperfusion; cardiomyopathy; heart failure; chemotherapy; clinical trials; COVID-19; niacinamide; vitamin B3; niacin; niagen; niaspan; mitochondria; tryptophan; diabetes; myocarditis; animal models; clinical trials Author: Noemi Rotllan, Mercedes Camacho, Mireia Tondo, Elena M. G. Diarte-Añazco, Marina Canyelles, Karen Alejandra Méndez-Lara, Sonia Benitez, Núria Alonso, Didac Mauricio, Joan Carles Escolà-Gil, Francisco Blanco-Vaca and Josep Julve Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Dec 3 10:44:22 2021 CET ModDate: Fri Dec 3 10:49:08 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 41 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1261998 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AALFUC+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 BFTPJC+VnURWPalladioL Type 1 Custom yes yes no 15 0 JZAGPC+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 FECTQK+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 QIQBKO+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 KUDXZB+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Info: Title: Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases Author: Noemi Rotllan, Mercedes Camacho, Mireia Tondo, Elena M. G. Diarte-Añazco, Marina Canyelles, Karen Alejandra Méndez-Lara, Sonia Benitez, Núria Alonso, Didac Mauricio, Joan Carles Escolà-Gil, Francisco Blanco-Vaca and Josep Julve Subject: Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. NAD+ bioavailability decreases with age and cardiometabolic conditions in several mammalian tissues. Compelling data suggest that declining tissue NAD+ is commonly related to mitochondrial dysfunction and might be considered as a therapeutic target. Thus, NAD+ replenishment by either genetic or natural dietary NAD+-increasing strategies has been recently demonstrated to be effective for improving the pathophysiology of cardiac and vascular health in different experimental models, as well as human health, to a lesser extent. Here, we review and discuss recent experimental evidence illustrating that increasing NAD+ bioavailability, particularly by the use of natural NAD+ precursors, may offer hope for new therapeutic strategies to prevent and treat cardiovascular diseases. Keywords: macrophage; aneurysm; atherosclerosis; ischemia/reperfusion; cardiomyopathy; heart failure; chemotherapy; clinical trials; COVID-19; niacinamide; vitamin B3; niacin; niagen; niaspan; mitochondria; tryptophan; diabetes; myocarditis; animal models; clinical trials Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Dec 03 10:44:22 CET 2021 ModDate: Fri Dec 03 10:49:08 CET 2021 ID: 0x207408d144568027027cda2332ff1ee4, 0x207408d144568027027cda2332ff1ee4 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VVSYYB+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: VVSYYB+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: JZAGPC+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: JZAGPC+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FECTQK+URWPalladioL-Bold FontSubset: 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