c290a2a30972670c40bec1a74c93ea95 pmc_34943471.pdf 0f89a6dc361b35f282d492641bc7a93804204912 pmc_34943471.pdf dd6258d374ea04d7d7bbeb9f52a0792435434ace5ff6018b5a541a4406fc488a pmc_34943471.pdf Title: Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting Subject: Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index for screening individuals at high risk of liver disease at the community level. This was a retrospective real-world study analyzing blood and serum test results from a central laboratory. The primary outcome was the number of individuals within each risk category for hepatic fibrosis: high risk (FIB4 3.25) and low risk (FIB4 < 1.3). The analysis included samples from 31,753 patients, of which 18,102 were aged 40 to 75 years. In these patients, the FIB4 index had been explicitly requested in 1852 (10.2%) cases and estimated ad hoc in the rest. Of the 263 (1.5%) cases with FIB4 3.25, the FIB4 index was requested in 46 (17.5%), and 52 (19.8%) showed evidence of liver fibrosis in their medical records, while the rest did not report any data regarding liver fibrosis. FIB4 is a simple score that can play a role as a “red flag” for early identification of patients at high risk of advanced liver fibrosis and their referral to specialized care. Keywords: chronic liver disease; liver fibrosis; metabolic associated fatty liver disease (MAFLD); screening; fibrosis 4 score Author: Albert Blanco-Grau, Pablo Gabriel-Medina, Francisco Rodriguez-Algarra, Yolanda Villena, Rosa Lopez-Martínez, Salvador Augustín, Mònica Pons, Luz-Maria Cruz, Ariadna Rando-Segura, Belen Enfedaque, Mar Riveiro, Ernesto Casis, Roser Ferrer-Costa, Maria Buti and Francisco Rodriguez-Frias Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Nov 30 08:15:24 2021 CET ModDate: Tue Nov 30 09:57:51 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 291591 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IOVOOE+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 EMQRPK+VnURWPalladioL Type 1 Custom yes yes no 15 0 JRVQKB+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 GVYVSG+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 UMDQNW+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 IYXNTT+CMSY10 Type 1 Builtin yes yes no 32 0 BXZUUH+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 62 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 66 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 70 0 CZKGAS+CMR10 Type 1 Builtin yes yes no 85 0 FAECIJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 92 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:37:48 CEST RepresentationInformation: pmc_34943471.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:06:32 CEST Size: 291591 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 248 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Data Sources Destination: subsection.2.1 Item: Title: Study Outcomes and FIB4 Estimate Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Patients Included and Their Distribution According to the FIB4 Index Destination: subsection.3.1 Item: Title: Medical Records of Patients with FIB4 3.25 Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting Author: Albert Blanco-Grau, Pablo Gabriel-Medina, Francisco Rodriguez-Algarra, Yolanda Villena, Rosa Lopez-Martínez, Salvador Augustín, Mònica Pons, Luz-Maria Cruz, Ariadna Rando-Segura, Belen Enfedaque, Mar Riveiro, Ernesto Casis, Roser Ferrer-Costa, Maria Buti and Francisco Rodriguez-Frias Subject: Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index for screening individuals at high risk of liver disease at the community level. This was a retrospective real-world study analyzing blood and serum test results from a central laboratory. The primary outcome was the number of individuals within each risk category for hepatic fibrosis: high risk (FIB4 3.25) and low risk (FIB4 < 1.3). The analysis included samples from 31,753 patients, of which 18,102 were aged 40 to 75 years. In these patients, the FIB4 index had been explicitly requested in 1852 (10.2%) cases and estimated ad hoc in the rest. Of the 263 (1.5%) cases with FIB4 3.25, the FIB4 index was requested in 46 (17.5%), and 52 (19.8%) showed evidence of liver fibrosis in their medical records, while the rest did not report any data regarding liver fibrosis. FIB4 is a simple score that can play a role as a “red flag” for early identification of patients at high risk of advanced liver fibrosis and their referral to specialized care. 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