b942159d22ff7ea8cb82981eb43246c7 pmc_34945175.pdf 7de961b1ac3ea03de76157779191e57e45dce3a2 pmc_34945175.pdf 24b606bdfe248b580184b992d3ea0a30bc4f8c7bd904c4140276684015a82565 pmc_34945175.pdf Title: Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study Subject: The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (p < 0.001) and 97.3% vs. 68.7% (p < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients. Keywords: melanoma; sentinel lymph node biopsy; survival Author: Antonio Tejera-Vaquerizo, Aram Boada, Simone Ribero, Susana Puig, Sabela Paradela, David Moreno-Ramírez, Javier Cañueto, Blanca de Unamuno-Bustos, Ana Brinca, Miguel A. Descalzo-Gallego, Simona Osella-Abate, Paola Cassoni, Sebastian Podlipnik, Cristina Carrera, Sergi Vidal-Sicart, Ramón Pigem, Agustí Toll, Ramón Rull, Llucìa Alos, Celia Requena, Isidro Bolumar, Víctor Traves, Ángel Pla, Almudena Fernández-Orland, Ane Jaka, María Teresa Fernández-Figueras, Nina Anika Richarz, Ricardo Vieira, Rafael Botella-Estrada, Concepción Román-Curto, Lara Ferrándiz-Pulido, Nicolás Iglesias-Pena, Carlos Ferrándiz, Josep Malvehy, Pietro Quaglino and Eduardo Nagore Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Dec 15 09:08:30 2021 CET ModDate: Wed Dec 15 09:13:07 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1070417 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JQFTXU+VnURWPalladioL-Bold Type 1 Custom 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Study Groups and Outcome Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Propensity Score Matching Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Missing Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Study Population Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Survival Rates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: Melanoma-Specific Survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Disease-Free Survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Overall Survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Prognostic Significance of SLNB Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Info: Title: Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study Author: Antonio Tejera-Vaquerizo, Aram Boada, Simone Ribero, Susana Puig, Sabela Paradela, David Moreno-Ramírez, Javier Cañueto, Blanca de Unamuno-Bustos, Ana Brinca, Miguel A. Descalzo-Gallego, Simona Osella-Abate, Paola Cassoni, Sebastian Podlipnik, Cristina Carrera, Sergi Vidal-Sicart, Ramón Pigem, Agustí Toll, Ramón Rull, Llucìa Alos, Celia Requena, Isidro Bolumar, Víctor Traves, Ángel Pla, Almudena Fernández-Orland, Ane Jaka, María Teresa Fernández-Figueras, Nina Anika Richarz, Ricardo Vieira, Rafael Botella-Estrada, Concepción Román-Curto, Lara Ferrándiz-Pulido, Nicolás Iglesias-Pena, Carlos Ferrándiz, Josep Malvehy, Pietro Quaglino and Eduardo Nagore Subject: The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98.5% vs. 77.3% (p < 0.001) and 97.3% vs. 68.7% (p < 0.001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients. 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